Peroxisomal Biogenesis Factor 19 (PEX19) ELISA Kits

PEX19 is necessary for early peroxisomal biogenesis. Zusätzlich bieten wir Ihnen PEX19 Antikörper (106) und PEX19 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human PEX19 PEX19 5824 P40855
Anti-Maus PEX19 PEX19 19298 Q8VCI5
Anti-Ratte PEX19 PEX19 289233  
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Weitere ELISA Kits für PEX19 Interaktionspartner

Human Peroxisomal Biogenesis Factor 19 (PEX19) Interaktionspartner

  1. that newly synthesized UBXD8 (zeige FAF2 ELISA Kits) is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3 (zeige PEX3 ELISA Kits), proteins hitherto exclusively implicated in peroxisome biogenesis

  2. Thus within the cell, PEX3 (zeige PEX3 ELISA Kits) is stabilized by PEX19 preventing PEX3 (zeige PEX3 ELISA Kits) aggregation.

  3. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 (zeige PEX26 ELISA Kits) in the cytosol and translocated it directly to peroxisomes by a TRC40 (zeige ASNA1 ELISA Kits)-independent class I pathway.

  4. PEX3 (zeige PEX3 ELISA Kits)-PEX19 interaction is crucial for de novo formation of peroxisomes in peroxisome-deficient cells.

  5. The crystal structure of the cytosolic domain of PEX3 (zeige PEX3 ELISA Kits) in complex with a PEX19-derived peptide. PEX3 (zeige PEX3 ELISA Kits) adopts a novel fold that is best described as a large helical bundle.

  6. a considerable functional diversity of the proteins encoded by two PEX19 splice variants and thereby provide first experimental evidence for specific biological functions of the different predicted domains of the PEX19 protein.

  7. PEX19 binds and stabilizes newly synthesized PMPs in the cytosol, binds to multiple PMP targeting signals (mPTSs), interacts with the hydrophobic domains of PMP targeting signals, and is essential for PMP targeting and import.

  8. Interaction of PEX3 (zeige PEX3 ELISA Kits) and PEX19 visualized by fluorescence resonance energy transfer (FRET).

  9. Pex19p has a role in assembly of PTS (zeige PTS ELISA Kits)-receptor docking complexes

  10. Results suggest that PEX3 (zeige PEX3 ELISA Kits) plays a selective, essential, and direct role in class I peroxisomal membrane protein (zeige PXMP2 ELISA Kits) import as a docking factor for PEX19.

PEX19 Antigen-Profil

Beschreibung des Gens

This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit PEX19

  • Peroxin 19 (Pex19) Antikörper
  • Peroxisomal farnesylated protein (Bm1_19905) Antikörper
  • peroxisomal biogenesis factor 19 (PEX19) Antikörper
  • peroxisomal biogenesis factor 19 (Pex19) Antikörper
  • BEST:GH03076 Antikörper
  • CG5325 Antikörper
  • D1S2223E Antikörper
  • DmelPex19 Antikörper
  • Dmel\\CG5325 Antikörper
  • HK33 Antikörper
  • PBD12A Antikörper
  • Peroxin-19 Antikörper
  • PMP1 Antikörper
  • PMPI Antikörper
  • PxF Antikörper
  • PXMP1 Antikörper

Bezeichner auf Proteinebene für PEX19

CG5325-PA , CG5325-PB , Pex19-PA , Pex19-PB , peroxin 19 , peroxisomal farnesylated protein , Peroxisomal farnesylated protein , 33 kDa housekeeping protein , housekeeping gene, 33kD , peroxin-19 , peroxisome biogenesis factor 19

GENE ID SPEZIES
34630 Drosophila melanogaster
6098885 Brugia malayi
5824 Homo sapiens
19298 Mus musculus
289233 Rattus norvegicus
521522 Bos taurus
100689302 Cricetulus griseus
100173241 Pongo abelii
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