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Peripheral Myelin Protein 22 Proteine (PMP22)

PMP22 encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Zusätzlich bieten wir Ihnen PMP22 Antikörper (95) und PMP22 Kits (25) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PMP22 5376 Q01453
Ratte PMP22 PMP22 24660 P25094
PMP22 18858 P16646
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
594,29 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
779,17 €
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PMP22 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Peripheral Myelin Protein 22 (PMP22) Interaktionspartnern

Zebrafish Peripheral Myelin Protein 22 (PMP22) Interaktionspartner

  1. The results of this study indicated that an adequate pmp22 transcription level is necessary for correct myelination of jawed vertebrates.

Human Peripheral Myelin Protein 22 (PMP22) Interaktionspartner

  1. We discovered that Tead1 (zeige TEAD1 Proteine) and co-activators Yap (zeige YAP1 Proteine) and Taz (zeige TAZ Proteine) are required for Pmp22 expression, as well as for the expression of Egr2 (zeige EGR2 Proteine) Tead1 (zeige TEAD1 Proteine) directly binds Pmp22 and Egr2 (zeige EGR2 Proteine) enhancers early in development and Tead1 (zeige TEAD1 Proteine) binding is induced during myelination, correlating with Pmp22 expression. The data identify Tead1 (zeige TEAD1 Proteine) as a novel regulator of Pmp22 expression during development in concert with Sox10 (zeige SOX10 Proteine) and Egr2 (zeige EGR2 Proteine)

  2. This study demonstrated We show that blink (zeige TGFb Proteine) reflex studies are reliable for identification of inherited demyelinating polyneuropathy (with pmp22 mutation) regardless of severity and can facilitate algorithmic decisions in genetic testing.

  3. Findings suggest that miR (zeige MLXIP Proteine)-200bc/429 inhibit OS cells proliferation and invasion by targeting PMP22, and function as a tumor suppressor.

  4. PMP22 deletion leads to functional, metabolic and macro-structural alterations in the afferent visual system of hereditary neuropathy with liability to pressure palsies patients.

  5. we report molecular and clinical characterizations of six subjects with the reciprocal phenomenon of deletions spanning both genes, i.e., PMP22-RAI1 (zeige DOM3Z Proteine) deletions. Systematic clinical studies revealed features consistent with SMS (zeige SMS Proteine), including features of intellectual disability, speech and gross motor delays, behavioral problems and ocular abnormalities.

  6. Data suggest that the father has carried the same duplication of the peripheral myelin protein 22 (PMP22) gene but with no detectable symptom may be due to irregular transmission pattern of the mutation.

  7. our data suggest that an alteration of mRNA processing could be a pathogenic mechanism in CMT1A.

  8. Data (including data from studies using recombinant proteins that lack typical in-vivo post-translational modifications such as palmitoylation) suggest PMP22 exhibits little tendency to partition into liquid-ordered domains of unilamellar vesicles.

  9. PMP22 gene knockdown inhibited progression of Chronic Myeloid Leukemia (zeige BCL11A Proteine).

  10. The common 17p deletion accounts for approximately 50% and PMP22 micromutations for approximately 2% of cases in a large consecutive cohort of Greek patients with suspected HNPP.

Mouse (Murine) Peripheral Myelin Protein 22 (PMP22) Interaktionspartner

  1. We discovered that Tead1 (zeige TEAD1 Proteine) and co-activators Yap (zeige YAP1 Proteine) and Taz (zeige TAZ Proteine) are required for Pmp22 expression, as well as for the expression of Egr2 (zeige EGR2 Proteine) Tead1 (zeige TEAD1 Proteine) directly binds Pmp22 and Egr2 (zeige EGR2 Proteine) enhancers early in development and Tead1 (zeige TEAD1 Proteine) binding is induced during myelination, correlating with Pmp22 expression. The data identify Tead1 (zeige TEAD1 Proteine) as a novel regulator of Pmp22 expression during development in concert with Sox10 (zeige SOX10 Proteine) and Egr2 (zeige EGR2 Proteine)

  2. The basal lamina and PMP22 act in concert to contribute to a resilience and integrity of peripheral nerves at the single fibre level.

  3. A role was identified for PMP22 in the linkage of the actin cytoskeleton with the plasma membrane.

  4. This study demonistrated that Paranodal dysmyelination in peripheral nerves of Trembler mice.

  5. This study showed that a number of ongoing pathogenic mechanisms contribute to the progression of the neuropathy in C22 mice, which initiates with abnormal expression of PMP22.

  6. Pxmp2 in the mammary fat pad is plays a critical role in stromal lipid homeostasis and in development of mammary gland epithelium in mice

  7. This study revealed a novel mechanism by which PMP22 deficiency affects nerve conduction not through removal of myelin, but through disruption of myelin junctions

  8. This study showed that mouse PMP22 is palmitoylated at C85 and mutating C85S abolishes PMP22 palmitoylation.

  9. Peripheral myelin protein 22 (PMP22) performs distinct actions on the formation, maturation, degeneration and regeneration of sciatic nerve myelin sheath.

  10. Egr2 (zeige EGR2 Proteine) and Sox10 (zeige SOX10 Proteine) activity are directly involved in mediating the developmental induction of Pmp22 expression through an intronic enhancer.

PMP22 Protein Überblick

Protein Überblick

This gene encodes an integral membrane protein that is a major component of myelin in the peripheral nervous system. Various mutations of this gene are causes of Charcot-Marie-Tooth disease Type IA, Dejerine-Sottas syndrome, and hereditary neuropathy with liability to pressure palsies. Alternative splicing of this gene results in three transcript variants that encode the same protein.

Genbezeichner und Symbole assoziert mit PMP22

  • peripheral myelin protein 22a (pmp22a)
  • peripheral myelin protein 22 (PMP22)
  • peripheral myelin protein 22 (pmp22)
  • peripheral myelin protein 22 (Pmp22)
  • peroxisomal membrane protein 2 (Pxmp2)
  • 22kDa Protein
  • CMT1A Protein
  • CMT1E Protein
  • DSS Protein
  • Gas-3 Protein
  • HMSNIA Protein
  • HNPP Protein
  • MGC69407 Protein
  • MGC80653 Protein
  • PMP22 Protein
  • Sp110 Protein
  • Tr Protein
  • trembler Protein
  • wu:fa04d03 Protein
  • wu:fa08d03 Protein

Bezeichner auf Proteinebene für PMP22

peripheral myelin protein 22 , growth arrest-specific protein 3 , PMP-22 , SAG , SR13 myelin protein , schwann cell membrane glycoprotein , peripheral myelin protein, 22 kDa , PAS positive glycoprotein , PASII , 22 kDa peroxisomal membrane protein , peroxisomal membrane protein 2, 22 kDa

GENE ID SPEZIES
334817 Danio rerio
417327 Gallus gallus
446837 Xenopus laevis
479509 Canis lupus familiaris
594946 Xenopus (Silurana) tropicalis
100302348 Ovis aries
5376 Homo sapiens
24660 Rattus norvegicus
18858 Mus musculus
534497 Bos taurus
100034146 Equus caballus
693527 Macaca mulatta
744977 Pan troglodytes
100172535 Pongo abelii
19301 Mus musculus
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