Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteine (PIN1)

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Zusätzlich bieten wir Ihnen Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Antikörper (219) und Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PIN1 241593  
PIN1 5300 Q13526
PIN1 298696  
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Top Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteine auf antikoerper-online.de

Showing 10 out of 21 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
419,05 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.128,41 €
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Hefe REACT_Apple His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.133,65 €
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Hefe Rhizopus oryzae His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.219,21 €
Details
Hefe Macaca fascicularis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.257,62 €
Details

PIN1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Am meisten referenzierte Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteine

  1. Human PIN1 Protein expressed in Escherichia coli (E. coli) - ABIN2002501 : Joseph, Yeh, Swenson, Means, Winkler: The peptidyl-prolyl isomerase Pin1. in Progress in cell cycle research 2003 (PubMed)
    Zeige alle 2 Referenzen für 2002501

Weitere Proteine zu Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Interaktionspartnern

Mouse (Murine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Interaktionspartner

  1. Direct delivery of recombinant Pin1 via fibroin nanoparticle encapsulated cationic lipid complex successfully rescued osteoblast differentiation of pin-1 deficient cells.

  2. Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury.

  3. in vivo functional analyses of Pin1 in the GFAP (zeige GFAP Proteine)-tTA;TRE (zeige TREH Proteine)-SmoA1 mouse model of Hedgehog (zeige SHH Proteine)-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival.

  4. Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (zeige INS Proteine); Pin1 interacts with Sik2 (salt-inducible kinase 2 (zeige SIK2 Proteine)) to regulate calcium signaling.

  5. Pin1 knockout in lupus-prone MRL lpr mi (zeige TLR7 Proteine)ce pre (zeige TLR9 Proteine)vents expres (zeige IRAK1 Proteine)sion o (zeige IRF7 Proteine)f lupus phenotype.

  6. By interacting with PSD-95 (zeige DLG4 Proteine), Pin1 dampens PSD-95 (zeige DLG4 Proteine) ability to complex with NMDARs, thus negatively affecting NMDAR (zeige GRIN1 Proteine) signaling and spine morphology.

  7. Oral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice.

  8. The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 (zeige DRGX Proteine) role in the process.

  9. Data show that peptidyl-prolyl isomerase (Pin1) inhibition inhibits high glucose (HG)-induced cardiac fibroblasts (CFs) proliferation and migration.

  10. Pin1 knock-out mice exhibited disturbed neuronal projections from the cerebral cortex and reduced white matter tracks.

Xenopus laevis Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Interaktionspartner

  1. Pin1 is an essential factor regulating CPEB degradation

  2. Pin1 binding is required for the inactivation of XeWee1B at M phase, presumably causing isomerization of the phospho-TP motif and thereby impairing the function of the Wee (zeige WEE1 Proteine)-box

Human Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Interaktionspartner

  1. The endoplasmic reticulum (ER) stress decreased Pin1 expression through p53 (zeige TP53 Proteine) activation, and this mechanism may be associated with ER stress-induced cell death. These data reported here support the importance of Pin1 as a potential target molecule mediating tumor development.

  2. our data suggested that miR (zeige MLXIP Proteine)-874-3p plays a tumour suppressive role in HCC (zeige FAM126A Proteine) through down-regulation of PIN1.

  3. in in silico gene expression analysis of human T-ALL samples we observed a significant correlation between Pin1 and Notch3 (zeige NOTCH3 Proteine) expression levels, which may further suggest a key role of the newly identified Notch3 (zeige NOTCH3 Proteine)-Pin1 axis in T-cell Acute Lymphoblastic Leukemia (T-ALL) aggressiveness and progression. Thus, combined suppression of Pin1 and Notch3 (zeige NOTCH3 Proteine) proteins may be exploited as an additional target therapy for T-ALL

  4. The study demonstrates the oncogenic role of PIN1 in NPC (zeige NPC1 Proteine) tumorigenesis, and shows that its overexpression can enhance tumor cell growth via the upregulation of cyclinD1.

  5. Pin1 expression was decreased remarkably in temporal lobe epilepsy patients compared to controls.

  6. Data, including data from studies conducted with knockout mice, suggest that PIN1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; PIN1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (zeige INS Proteine); PIN1 interacts with Sik2 (salt-inducible kinase 2 (zeige SIK2 Proteine)) to regulate calcium signaling.

  7. Knockdown of PIN1 potently blocks TLR-7 (zeige TLR7 Proteine)/TLR-9 (zeige TLR9 Proteine)/Pin1/IRAK-1 (zeige IRAK1 Proteine)/IRF-7 (zeige IRF7 Proteine) signaling in vitro.

  8. Data indicate the complexity of interactions between Pin1 and activated IRAK1 (zeige IRAK1 Proteine), suggesting that phosphorylation of neighboring Ser (zeige SIGLEC1 Proteine)/Thr (zeige TRH Proteine)-Pro motifs in proteins might provide competitive advantage at cellular concentrations for engaging with Pin1.

  9. Surprisingly, the authors discover that Pin1 does not promote phosphorylated tau-induced microtubule formation in vitro, refuting the commonly accepted model in which Pin1 binding and catalysis on the A180 epitope restores the function of the Alzheimer's associated phosphorylated tau in tubulin (zeige TUBB Proteine) assembly.

  10. Importantly, site-specific measurements of Pin1-catalysis of CDK2 (zeige CDK2 Proteine)/CycA (zeige CCNA2 Proteine)-phosphorylated full-length tau reveal a number of sites that are catalyzed simultaneously with different efficiencies.

Cow (Bovine) Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Interaktionspartner

  1. The data provide the first evidence that Pin 1 expression in the granulosa cells but not the theca cells changes during follicular development, and that FSH (zeige BRD2 Proteine) stimulate the expression of the Pin 1 gene.

Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) Protein Überblick

Protein Überblick

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit PIN1

  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1 (Pin1rt1)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-b)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1-a)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1)
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (ppiD)
  • peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PITG_11123)
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1)
  • protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Pin1)
  • 0610025L01Rik Protein
  • D9Bwg1161e Protein
  • DOD Protein
  • OTTMUSG00000014964 Protein
  • pin1 Protein
  • Pin1-ps1 Protein
  • pin1a Protein
  • pin1b Protein
  • Pin1l Protein
  • UBL5 Protein

Bezeichner auf Proteinebene für PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1, pseudogene 1 , prolyl isomerase Pin1 b , prolyl isomerase Pin1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b , protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1 , peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a , peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 , PPIase Pin1 , protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 , rotamase Pin1 , peptidyl-prolyl cis-trans isomerase Pin1

GENE ID SPEZIES
241593 Mus musculus
399385 Xenopus laevis
493472 Xenopus (Silurana) tropicalis
503670 Xenopus laevis
711095 Macaca mulatta
745021 Pan troglodytes
5807350 Sorangium cellulosum So ce56
9476290 Phytophthora infestans T30-4
5300 Homo sapiens
484963 Canis lupus familiaris
298696 Rattus norvegicus
535470 Bos taurus
100512827 Sus scrofa
23988 Mus musculus
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