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Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. Zusätzlich bieten wir Ihnen Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Proteine (19) und Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PIN1 Primary Antibody für ICC, IF - ABIN438364
Islam, Bae, Yoon, Woo, Baek, Kim, Uchida, Ryoo: Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP. in Journal of cellular physiology 2014
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Rat (Rattus) Polyclonal PIN1 Primary Antibody für ELISA, WB - ABIN251689
Pastorino, Sun, Lu, Zhou, Balastik, Finn, Wulf, Lim, Li, Li, Xia, Nicholson, Lu: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. in Nature 2006
Pin1 silencing in lymphomas retarded disease progression in mice, making Pin1 an attractive therapeutic target in Myc (zeige MYC Antikörper)-driven tumors.
Pin1 enhances adipocyte differentiation by regulating the function of PPARgamma (zeige PPARG Antikörper).
Pin1 serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau.
Direct delivery of recombinant Pin1 via fibroin nanoparticle encapsulated cationic lipid complex successfully rescued osteoblast differentiation of pin-1 deficient cells.
Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury.
in vivo functional analyses of Pin1 in the GFAP (zeige GFAP Antikörper)-tTA;TRE (zeige TREH Antikörper)-SmoA1 mouse model of Hedgehog (zeige SHH Antikörper)-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival.
Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (zeige INS Antikörper); Pin1 interacts with Sik2 (salt-inducible kinase 2 (zeige SIK2 Antikörper)) to regulate calcium signaling.
Pin1 knockout in lupus-prone MRL lpr mi (zeige TLR7 Antikörper)ce pre (zeige TLR9 Antikörper)vents expres (zeige IRAK1 Antikörper)sion o (zeige IRF7 Antikörper)f lupus phenotype.
By interacting with PSD-95 (zeige DLG4 Antikörper), Pin1 dampens PSD-95 (zeige DLG4 Antikörper) ability to complex with NMDARs, thus negatively affecting NMDAR (zeige GRIN1 Antikörper) signaling and spine morphology.
Oral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice.
Pin1 is an essential factor regulating CPEB degradation
Pin1 binding is required for the inactivation of XeWee1B at M phase, presumably causing isomerization of the phospho-TP motif and thereby impairing the function of the Wee (zeige WEE1 Antikörper)-box
Parallel folding pathways of PIN1 Fip35 WW domain (zeige DRP2 Antikörper) have been explained by infrared spectra and their computer simulations.
High PIN1 expression is associated with stomach neoplasms.
Pin1 is a novel regulator of ATF1 (zeige AFT1 Antikörper) at Thr184.
The dynamic basis for signal propagation in Pin1 N-terminal binding domain WW has been described.
The endoplasmic reticulum (ER) stress decreased Pin1 expression through p53 (zeige TP53 Antikörper) activation, and this mechanism may be associated with ER stress-induced cell death. These data reported here support the importance of Pin1 as a potential target molecule mediating tumor development.
our data suggested that miR (zeige MLXIP Antikörper)-874-3p plays a tumour suppressive role in HCC (zeige FAM126A Antikörper) through down-regulation of PIN1.
in in silico gene expression analysis of human T-ALL samples we observed a significant correlation between Pin1 and Notch3 (zeige NOTCH3 Antikörper) expression levels, which may further suggest a key role of the newly identified Notch3 (zeige NOTCH3 Antikörper)-Pin1 axis in T-cell Acute Lymphoblastic Leukemia (T-ALL) aggressiveness and progression. Thus, combined suppression of Pin1 and Notch3 (zeige NOTCH3 Antikörper) proteins may be exploited as an additional target therapy for T-ALL
The study demonstrates the oncogenic role of PIN1 in NPC (zeige NPC1 Antikörper) tumorigenesis, and shows that its overexpression can enhance tumor cell growth via the upregulation of cyclinD1.
Pin1 expression was decreased remarkably in temporal lobe epilepsy patients compared to controls.
Data, including data from studies conducted with knockout mice, suggest that PIN1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; PIN1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin (zeige INS Antikörper); PIN1 interacts with Sik2 (salt-inducible kinase 2 (zeige SIK2 Antikörper)) to regulate calcium signaling.
The data provide the first evidence that Pin 1 expression in the granulosa cells but not the theca cells changes during follicular development, and that FSH (zeige BRD2 Antikörper) stimulate the expression of the Pin 1 gene.
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
, peptidylprolyl cis/trans isomerase, NIMA-interacting 1, pseudogene 1
, prolyl isomerase Pin1 b
, prolyl isomerase Pin1
, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b
, protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a
, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
, PPIase Pin1
, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
, rotamase Pin1
, peptidyl-prolyl cis-trans isomerase Pin1