anti-Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Antikörper

PNPLA2 encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Zusätzlich bieten wir Ihnen Patatin-Like phospholipase Domain Containing 2 Kits (39) und Patatin-Like phospholipase Domain Containing 2 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PNPLA2 57104 Q96AD5
PNPLA2 66853 Q8BJ56
PNPLA2 361676 P0C548
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Top anti-Patatin-Like phospholipase Domain Containing 2 Antikörper auf antikoerper-online.de

Showing 10 out of 176 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA, IHC, IHC (fro), IHC (p), WB Western Blot: PEDF R/PNPLA2/ATGL Antibody (2G2) [NBP1-25852] - The extracts of mouse kidney (20ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human ATGL (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Immunohistochemistry-Paraffin: PEDF R/PNPLA2/ATGL Antibody (2G2) [NBP1-25852] - Human ATGL (1:25) for 2 hours at room temperature. Antigen retrieval was performed in 0.1M sodium citrate buffer and detected using Diaminobenzidine (DAB). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$415.44
Details
Human Kaninchen Unkonjugiert IP, IHC, WB Western blot analysis of ATGL expression in rat kidney tissue lysate. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN190844 (0.5µg/ml) staining of Human Adipose lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Maus Unkonjugiert EIA, IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$412.50
Details
Human Maus Unkonjugiert CyTOF, FACS, WB Detection of PEDF R/PNPLA2 in Y-79 Human Cell Line by Flow Cytometry. Y-79 human retinoblastoma cell line was stained with Mouse Anti-Human PEDF R/PNPLA2 Monoclonal Antibody. 100 μg Anmelden zum Anzeigen 8 bis 9 Tage
$293.25
Details
Human Ziege Unkonjugiert IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: PEDF R/PNPLA2/ATGL Antibody [ABIN2529204] - Staining of Human Heart. Western Blot: PEDF R/PNPLA2/ATGL Antibody [ABIN2529204] - Staining of Human Adipose lysate. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Ziege Unkonjugiert ELISA, WB ABIN334463 (0.03µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: PEDF R/PNPLA2/ATGL Antibody [NBP1-00226] - Analysis of PEDF R/PNPLA2/ATGL in Human Heart lysate (35ug protein in RIPA buffer) using this antibody at 0.03ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Rind (Kuh) Ziege Unkonjugiert IHC (p), WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$411.13
Details
Rind (Kuh) Ziege Unkonjugiert IHC (p), ELISA Human Heart (formalin-fixed, paraffin-embedded) stained with PNPLA2 antibody ABIN337131 at 2.5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$451.00
Details

PNPLA2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-Patatin-Like phospholipase Domain Containing 2 Antikörper

  1. Human Polyclonal PNPLA2 Primary Antibody für IHC (p), IHC - ABIN252920 : Schoenborn, Heid, Vollmert, Lingenhel, Adams, Hopkins, Illig, Zimmermann, Zechner, Hunt, Kronenberg: The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes. in Diabetes 2006 (PubMed)

  2. Human Polyclonal PNPLA2 Primary Antibody für ELISA, WB - ABIN314328 : Steinberg, Kemp, Watt: Adipocyte triglyceride lipase expression in human obesity. in American journal of physiology. Endocrinology and metabolism 2007 (PubMed)

  3. Polyclonal PNPLA2 Primary Antibody für WB - ABIN540337 : Haemmerle, Lass, Zimmermann, Gorkiewicz, Meyer, Rozman, Heldmaier, Maier, Theussl, Eder, Kratky, Wagner, Klingenspor, Hoefler, Zechner: Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. in Science (New York, N.Y.) 2006 (PubMed)

  4. Human Monoclonal PNPLA2 Primary Antibody für ELISA, IHC - ABIN449788 : Mason, Meex, Russell, Canny, Watt: Cellular localization and associations of the major lipolytic proteins in human skeletal muscle at rest and during exercise. in PLoS ONE 2014 (PubMed)

  5. Human Monoclonal PNPLA2 Primary Antibody für CyTOF, FACS - ABIN4899287 : He, Wu, Gong, Luo, Zhang, Li, Lu, Wei, Yang: Enhanced efficacy of combination therapy with adeno‑associated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma. in Molecular medicine reports 2014 (PubMed)

Weitere Antikörper gegen Patatin-Like phospholipase Domain Containing 2 Interaktionspartner

Goat Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. the ATGL gene plays an important role in triglyceride lipolysis in GMECs; ATGL may be involved in lipid metabolism during lactation

Human Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. a Snail1 (zeige SNAI1 Antikörper)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  2. ABHD5 (zeige ABHD5 Antikörper) possesses a PNPLA2-independent function in regulating autophagy and tumorigenesis.

  3. Oxidative stress decreased the levels of PNPLA2 transcripts with no effect on ALOX5 (zeige ALOX5 Antikörper) expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 gene decreased both LTB4 (zeige PTGR1 Antikörper) levels and death of RPE (zeige RPE Antikörper) cells undergoing oxidative stress.

  4. Results suggest that increased adipose triglyceride lipase (ATGL) expression is associated with increased adiposity and stromal proliferation in patients with pancreatic ductal adenocarcinoma (PDAC).

  5. A missense mutation in PNPLA2 is the rare cause of severe dilated cardiomyopathy secondary to neutral lipid storage disease.

  6. A novel deletion was identified in PNPLA2 protein from a patient with complete deficiency of adipose triglyceride lipase.

  7. Rab32 (zeige RAB32 Antikörper) controls intracellular lipid accumulation through inducing lipolysis via enhancing ATGL expression indirectly.

  8. Data indicate that a tumor suppressor mechanism by which G0/G1 switch gene 2 (zeige G0S2 Antikörper) product (G0S2 (zeige G0S2 Antikörper)) directly inhibits activity of a key intracellular adipose triglyceride lipase (ATGL).

  9. Authors show that rat ATGL, coactivated by rat CGI-58 (zeige ABHD5 Antikörper), efficiently hydrolyzes triglycerides and retinyl ester.

  10. PNPLA2 mutations were associated with an extended phenotype, including brain involvement in cases of neutral lipid-storage disease with myopathy.

Mouse (Murine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. a Snail1 (zeige SNAI1 Antikörper)-ATGL axis that regulates adipose lipolysis and fatty acid release, is reported.

  2. CGI-58 (zeige ABHD5 Antikörper) regulates hepatic neutral lipid storage and inflammation in the genetic absence of ATGL.

  3. Enhanced lipolysis in response to mitochondrial uncoupling relies on a form of autophagy as lipid droplets are captured by endolysosomal vesicles which is HSL (zeige LIPE Antikörper)/ATGL-independent.

  4. The Atgl is down-regulated by the basal transcription factor Sp1 (zeige SP1 Antikörper) in preadipocytes and that the magnitude of down-regulation depends on interactions between Sp1 (zeige SP1 Antikörper) and peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Antikörper)).

  5. TAG synthesis and levels of PUFA-TAGs were lowered by the diacylglycerol acyltransferase (DGAT)1 (zeige DGAT1 Antikörper) inhibitor, T863. The lipase (zeige LIPG Antikörper) inhibitor, Atglistatin, increased the levels of TAG in both WT and ATGL-deficient mouse Hepatic stellate cell (HSC (zeige FUT1 Antikörper)). Both Atglistatin and T863 inhibited the induction of activation marker, alpha-smooth muscle actin (zeige ACTG2 Antikörper), in rat HSCs, but not in mouse HSCs.

  6. G0S2 (zeige G0S2 Antikörper) protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2 (zeige G0S2 Antikörper)

  7. Atgl deficiency induces podocyte apoptosis and leads to glomerular filtration barrier damage.

  8. These data raise the possibility that ATGL deficiency could impair the renal fatty acid metabolism though inhibiting PPARalphaexpression, which may lead to lipid deposition and cell apoptosis of PCT (zeige UROD Antikörper), and finally contribute to the renal fibrosis and dysfunction

  9. Markers of mitochondrial content and respiration were increased in adipose tissue from ATGL knockout mice.

  10. ase (zeige ARSE Antikörper). Similar changes of GPNMB and G0S2 (zeige G0S2 Antikörper) expression were present in a human liposarcoma database. These results show that a previously-unknown, fully penetrant epistatic interaction between Pnpla2 and Lipe (zeige LIPE Antikörper) can cause liposarcoma in mice. DAKO mice provide a promising model for studying early premalignant changes that lead to late-onset malignant disease.

Pig (Porcine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. Results identified functional polymorphisms providing new evidence of PNPLA2 as an important candidate gene for fat deposition and carcass traits in pigs.

  2. Resveratrol activated sirtuin 1 (Sirt1 (zeige SIRT1 Antikörper)) gene expression and increased adipose triglyceride lipase (ATGL) gene expression and glycerol release. Furthermore, this study found the opposite Sirt1 (zeige SIRT1 Antikörper) regulation pattern for PPARgamma (zeige PPARG Antikörper) to that of ATGL in adipocytes.

  3. analysis of porcine adipose triglyceride lipase (PNPLA2) gene

  4. JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper) and MAPK (zeige MAPK1 Antikörper) signaling pathways, as well as PPAR gamma (zeige PPARG Antikörper) all played important roles in the ATGL expression mediated by leptin (zeige LEP Antikörper)

  5. patatin-like phospholipase domain containing 2 gene (PNPLA2) is assiged to chromosome 2 in pigs.

  6. ATGL expression reacts to hormonal stimuli and plays a role in catecholamine-induced lipolysis in porcine adipose tissue.

Cow (Bovine) Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Interaktionspartner

  1. Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue.

Patatin-Like phospholipase Domain Containing 2 (PNPLA2) Antigen-Profil

Protein Überblick

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy.

Genbezeichner und Symbole assoziert mit PNPLA2

  • patatin-like phospholipase domain containing 3 (pnpla3) Antikörper
  • patatin like phospholipase domain containing 2 (PNPLA2) Antikörper
  • patatin like phospholipase domain containing 2 (pnpla2) Antikörper
  • patatin-like phospholipase domain containing 2 (Pnpla2) Antikörper
  • 0610039C21Rik Antikörper
  • 1110001C14Rik Antikörper
  • Atgl Antikörper
  • iPLA2zeta Antikörper
  • PEDF-R Antikörper
  • pnpla2 Antikörper
  • RGD1309044 Antikörper
  • TTS-2.2 Antikörper
  • TTS2 Antikörper
  • zgc:92195 Antikörper

Bezeichner auf Proteinebene für PNPLA2

patatin-like phospholipase domain-containing protein 2 , patatin-like phospholipase domain containing 2 , adipose triglyceride lipase , IPLA2-zeta , TTS2.2 , calcium-independent phospholipase A2 , desnutrin , patatin-like phospholipase domain containing protein 2 , pigment epithelium-derived factor , transport-secretion protein 2.2 , triglyceride hydrolase , transport-secretion protein , PNPLA2/ATGL

GENE ID SPEZIES
436610 Danio rerio
611403 Canis lupus familiaris
780152 Xenopus (Silurana) tropicalis
100219060 Taeniopygia guttata
100294555 Meleagris gallopavo
100860889 Capra hircus
57104 Homo sapiens
66853 Mus musculus
100049704 Sus scrofa
508493 Bos taurus
431066 Gallus gallus
361676 Rattus norvegicus
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