Pappalysin 2 Proteine (PAPPA2)

Metalloproteinase which specifically cleaves IGFBP-5. Zusätzlich bieten wir Ihnen Pappalysin 2 Antikörper (49) und Pappalysin 2 Kits (26) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus PAPPA2 PAPPA2 23850  
PAPPA2 60676 Q9BXP8
Ratte PAPPA2 PAPPA2 364027  
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Showing 4 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Human His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
525,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
685,71 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
870,83 €
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PAPPA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,

Am meisten referenzierte Pappalysin 2 Proteine

  1. Human PAPPA2 Protein expressed in Human Cells - ABIN2003006 : Crosley, Durland, Seethram, MacRae, Gruslin, Christians: First-trimester levels of pregnancy-associated plasma protein A2 (PAPP-A2) in the maternal circulation are elevated in pregnancies that subsequently develop preeclampsia. in Reproductive sciences (Thousand Oaks, Calif.) 2014 (PubMed)

Weitere Proteine zu Pappalysin 2 (PAPPA2) Interaktionspartnern

Zebrafish Pappalysin 2 (PAPPA2) Interaktionspartner

  1. Papp-a2 modulates Bmp and Notch (zeige NOTCH1 Proteine) signaling by independent mechanisms in zebrafish embryos to control cranial cartilage development and angiogenesis.

Mouse (Murine) Pappalysin 2 (PAPPA2) Interaktionspartner

  1. Locally-produced Pappa2 in osteoblasts, epiphysis, and metaphysis, is required for normal postnatal bone growth.

  2. Despite a dramatic disruption of the balance between circulating IGF-I (zeige IGF1 Proteine), IGFBP-3 (zeige IGFBP3 Proteine) and -5, we found no effects of Pappa2 deletion on glucose metabolism, weight gain or adiposity on a high-fat diet.

  3. Pappa2 deletion had no effect on female reproduction and subtle effects on male fertility.

  4. Pappa2 is responsible for the effects of the previously-identified QTL, demonstrating that natural variation in the Pappa2 gene contributes to variation in postnatal growth in mice

  5. investigation of biological role of PAPP-A2 using knockout mice, heterozygotes, primary fibroblasts: The most striking phenotype of PAPP-A2 KO mice was postnatal growth retardation. PAPP-A2 KO mice were fertile, but exhibited compromised fecundity.

  6. Elevated PAPPA2 levels are a consequence rather than a cause of pregnancy complications.

  7. The refinement of the target region to four genes and the finding that the QTL affects IGFBP-5 (zeige IGFBP5 Proteine) levels suggest that PAPPA2 may be involved with normal postnatal growth

  8. Pappa2 expression also shows specific localization within the mouse embryo and therefore may play roles in fetal development, independent of its action in the placenta

Human Pappalysin 2 (PAPPA2) Interaktionspartner

  1. These patients provide important insights into the regulation of longitudinal growth in humans, documenting the critical role of PAPP-A2 in releasing IGF-I (zeige IGF1 Proteine) from its binding proteins.

  2. Short-term treatment with progressive doses of rhIGF1 (recombinant human insulin-like growth factor-1 (zeige IGF1 Proteine)) improved growth in two siblings with deficiency of PAPP-A2 (pregnancy-associated plasma protein-A2) [due to a homozygous loss-of-function frameshift mutation in exon 3 of the PAPP-A2 gene (p.D643fs25*)] that resulted in postnatal growth failure due to resulting decrease in IGF1 (zeige IGF1 Proteine) bioavailability. [CASE REPORT]

  3. in situ hybridization (ISH (zeige ANTXR2 Proteine)) and immunohistochemistry (IHC) were employed to examine the spatial and temporal expression of PAPPA2 in the human fetomaternal interface.

  4. PAPP-A2 is differentially expressed in different trophoblast populations and shows strong down regulation in the mid second trimester in chorionic villous samples.

  5. The association between this PAPPA2 single nucleotide polymorphism and developmental dysplasia of the hip was evaluated.

  6. The upregulation of PAPP-A2 observed in preeclampsia at term occurs early in pregnancy, before the symptoms develop.

  7. PAPPA2 may be upregulated in severe pre-eclampsia and, functionally, this may be mediated via increased placental hypoxia known to occur with this pregnancy disorder.

  8. The existence of this assay will enable an assessment of the biomarker potential of PAPP-A2 in pre-eclampsia as well as other clinical conditions.

  9. Association of a single nucleotide polymorphism in pregnancy-associated plasma protein-A2 with developmental dysplasia of the hip

  10. factors previously known to be highly expressed in preeclamptic placentae (PGE2 and TNF-alpha (zeige TNF Proteine)), contribute to the upregulation of PAPPA2. results are consistent with the hypothesis that PAPPA2 is upregulated as a consequence of placental pathology

Cow (Bovine) Pappalysin 2 (PAPPA2) Interaktionspartner

  1. Variants in the pregnancy-associated plasma protein-A2 gene on Bos taurus autosome 16 are associated with daughter calving ease and productive life in Holstein cattle.

Pappalysin 2 (PAPPA2) Protein Überblick

Protein Überblick

Metalloproteinase which specifically cleaves IGFBP-5. Shows limited proteolysis toward IGFBP-3.

Genbezeichner und Symbole assoziert mit Pappalysin 2 Proteine (PAPPA2)

  • pappalysin 2 (PAPPA2)
  • pappalysin 2 (pappa2)
  • pappalysin 2 (Pappa2)
  • pappalysin 2 (LOC100357077)
  • PAPP-A2 Protein
  • PAPP-E Protein
  • PAPPE Protein
  • PLAC3 Protein
  • si:dkey-39f8.1 Protein

Bezeichner auf Proteinebene für Pappalysin 2 Proteine (PAPPA2)

pappalysin 2 , pappalysin-2-like , placenta-specific 3 , pregnancy-associated plasma preproprotein-A2 , pregnancy-associated plasma protein-E , pappalysin-2 , pregnancy-associated plasma protein E1

GENE ID SPEZIES
457543 Pan troglodytes
567038 Danio rerio
100021506 Monodelphis domestica
100052718 Equus caballus
100447000 Pongo abelii
100468592 Ailuropoda melanoleuca
100491868 Xenopus (Silurana) tropicalis
100567326 Anolis carolinensis
100582901 Nomascus leucogenys
23850 Mus musculus
60676 Homo sapiens
364027 Rattus norvegicus
100357077 Oryctolagus cuniculus
100736235 Cavia porcellus
100521390 Sus scrofa
480058 Canis lupus familiaris
538320 Bos taurus
429071 Gallus gallus
101118205 Ovis aries
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