PTEN Induced Putative Kinase 1 Proteine (PINK1)

PINK1 encodes a serine/threonine protein kinase that localizes to mitochondria. Zusätzlich bieten wir Ihnen PINK1 Antikörper (240) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PINK1 65018 Q9BXM7
PINK1 68943 Q99MQ3
Ratte PINK1 PINK1 298575  
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
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Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$640.00
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Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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Escherichia coli (E. coli) Human MBP tag,His tag   100 μg Anmelden zum Anzeigen 5 bis 8 Tage
$683.55
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Baculovirus infected Insect Cells Human GST tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage
$570.24
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$344.14
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$838.75
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PINK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , , ,
Mouse (Murine) ,
, ,

Weitere Proteine zu PTEN Induced Putative Kinase 1 (PINK1) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) PTEN Induced Putative Kinase 1 (PINK1) Interaktionspartner

  1. Maintenance of tissue homeostasis upon reduction of Pink1 or Parkin (zeige PARK2 Proteine) appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  2. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin (zeige PARK2 Proteine) flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  3. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin (zeige PARK2 Proteine) and for subsequent phosphorylation and activation of Parkin (zeige PARK2 Proteine).

  4. A pink1 genomic knock-in allele was generated to monitor the dynamic expression pattern of PINK1. The spatiotemporal expression pattern of PINK1 correlates with the cell-type specific mitochondrial clearance or persistence. PINK1 and PARKIN (zeige PARK2 Proteine) function epistatically to mediate timely specific mitophagy during Drosophila midgut metamorphosis.

  5. Our data indicate that PINK1 and Parkin (zeige PARK2 Proteine) play an important role in FUS (zeige FUS Proteine)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (zeige FUS Proteine) proteinopathy and PINK1/Parkin (zeige PARK2 Proteine) genes, providing new insights into the pathogenesis of FUS (zeige FUS Proteine) proteinopathy.

  6. we show that overexpression of Drosophila Clu (zeige CLU Proteine) complements PINK1, but not parkin (zeige PARK2 Proteine), mutant muscles. Thus, Clu (zeige CLU Proteine) is essential for mitochondrial homeostasis and functions in concert with Parkin (zeige PARK2 Proteine) and VCP (zeige vcp Proteine) for Marf (zeige MFN2 Proteine) degradation to promote damaged mitochondrial clearance.

  7. In addition, a PINK1 mutant, which induced mitochondrial enlargement and had been considered as a Drosophila model of Parkinson's disease (PD), caused fly muscle defects, and the loss of vimar could rescue these defects. Furthermore, we found that the mammalian homolog of Vimar, RAP1GDS1 (zeige RAP1GDS1 Proteine), played a similar role in regulating mitochondrial morphology, suggesting a functional conservation of this GEF (zeige SLC2A4RG Proteine) member.

  8. Buffy has a role enhancing the loss of parkin (zeige PARK2 Proteine) and suppressing the loss of Pink1 phenotypes in Drosophila

  9. PINK1-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  10. Clu (zeige CLU Proteine) directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

Zebrafish PTEN Induced Putative Kinase 1 (PINK1) Interaktionspartner

  1. Pink1-depleted zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons.

  2. Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway.

  3. Distinct groups of dopaminergic neurons are sensitive to targeted loss of Pink1 factor in a morphant fish model of toxin-induced Parkinson's disease.

  4. Morpholino-mediated loss of pink1 function in zebrafish profoundly affects the development of dopaminergic neurons in the ventral diencephalon and affects behaviour of the zebrafish larvae, namely their response to tactile stimuli and locomotor behavior.

Human PTEN Induced Putative Kinase 1 (PINK1) Interaktionspartner

  1. an impaired PINK1-PARK2 (zeige PARK2 Proteine)-mediated neuroimmunology pathway contributes to septic death.

  2. We demonstrated that miR (zeige MLXIP Proteine)-27a and miR (zeige MLXIP Proteine)-27b regulate PINK1 expression and autophagic clearance of damaged mitochondria

  3. The effects of variants in the Parkin (zeige PARK2 Proteine), PINK1, and DJ-1 (zeige PARK7 Proteine) genes along with evidence for their pathogenicity have been summarized. (Review)

  4. data suggest that ROS (zeige ROS1 Proteine) may act as a trigger for the induction of Parkin (zeige PARK2 Proteine)/PINK1-dependent mitophagy.

  5. Adipogenic process can be dissected into 3 stages according to the participation of PARL (zeige PARL Proteine)-PINK1-Parkin (zeige PARK2 Proteine) system. Findings reveal the sequential adipogenic events directed by PARL (zeige PARL Proteine)-PINK1-Parkin (zeige PARK2 Proteine) system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  6. PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 and Parkin (zeige PARK2 Proteine).

  7. We report that loss of PINK1 contributes to the Warburg effect through ROS (zeige ROS1 Proteine)-dependent stabilization of hypoxia-inducible factor-1A and reduced pyruvate kinase muscle isozyme 2 activity which highlight the importance of PINK1 and reactive oxygen species balance in normal and tumor cells.

  8. PINK1 disease mutants failed to recruit synphilin-1 (zeige SNCAIP Proteine) and did not activate mitophagy, indicating that PINK1-synphilin-1 (zeige SNCAIP Proteine)-SIAH-1 (zeige SIAH1 Proteine) represents a new parkin (zeige PARK2 Proteine)-independent mitophagy pathway. Drugs that activate this pathway will provide a novel strategy to promote the clearance of damaged mitochondria in Parkinson's disease.

  9. PINK1 p.G411S is a rare genetic risk factor with a relatively large effect size conferred by a partial dominant-negative function phenotype.

  10. In summary, our results demonstrate that PINK1 promoted hepatic IR via JNK (zeige MAPK8 Proteine) and ERK (zeige EPHB2 Proteine) pathway in PA treated HepG2 cells, implying a novel molecular target for the therapy of diabetes.

Mouse (Murine) PTEN Induced Putative Kinase 1 (PINK1) Interaktionspartner

  1. an impaired PINK1-PARK2 (zeige PARK2 Proteine)-mediated neuroimmunology pathway contributes to septic death.

  2. study identifies a new role of Dual-AKAP1 (zeige AKAP1 Proteine) in regulating mitochondrial trafficking through Miro-2 (zeige RHOT2 Proteine), and supports a model in which PINK1 and mitochondrial PKA participate in a similar neuroprotective signaling pathway to maintain dendrite connectivity

  3. Study showed that apoptosis is an important form of cellular degeneration in lipopolysaccharide (LPS (zeige TLR4 Proteine)-sensitized hypoxic-ischemic (HI) injury in the immature brain. Loss of PINK1 can protect the immature brain against cell apoptosis induced by LPS (zeige TLR4 Proteine)-sensitized HI injury. Moreover, alpha-Syn plays a neuroprotective role in LPS (zeige TLR4 Proteine)-sensitized HI brain damage in PINK1-knockout neonatal mice

  4. the results suggest that BNIP3 (zeige BNIP3 Proteine) plays a vital role in regulating PINK1 mitochondrial outer membrane localization, the proteolytic process of PINK1 and PINK1/parkin (zeige PARK2 Proteine)-mediated mitophagy under physiological conditions.

  5. lack of PINK1 causes increased excitatory transmission and neurotransmitter release in the hippocampus, which might lead to the cognitive decline often observed in Parkinson's disease

  6. The identification of PINK1 and Parkin (zeige PARK2 Proteine) as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  7. PINK1 deficiency causes defects in GFAP (zeige GFAP Proteine)-positive astrogliogenesis during brain development.

  8. The findings of this study show a CB1R (zeige CNR1 Proteine) dysfunction at corticostriatal synapses in PINK1(-/-), but not in PINK1(+/-) mice, and provide a mechanistic link to the distinct plasticity deficits observed in both genotypes.

  9. Loss of PINK1 inhibits Ca2+ efflux by NCLX and triggers mitochondrial depolarization.

  10. PINK1 gene knockout can protect neonatal mice from hypoxic-ischemic brain damage (HIBD).

PINK1 Protein Überblick

Protein Überblick

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.

Genbezeichner und Symbole assoziert mit PINK1

  • PTEN-induced putative kinase 1 (Pink1)
  • PTEN induced putative kinase 1 (PINK1)
  • PTEN induced putative kinase 1 (pink1)
  • PTEN induced putative kinase 1 (Pink1)
  • 1190006F07Rik Protein
  • AU042772 Protein
  • AW557854 Protein
  • BEST:GH23468 Protein
  • BRPK Protein
  • CG4523 Protein
  • Dmel\\CG4523 Protein
  • dPink1 Protein
  • mFLJ00387 Protein
  • PARK6 Protein
  • PINK Protein
  • pink1 Protein
  • wu:fc39e12 Protein
  • zgc:101729 Protein

Bezeichner auf Proteinebene für PINK1

CG4523-PA , CG4523-PB , CG4523-PC , CG4523-PD , CG4523-PE , CG4523-PF , CG4523-PG , CG4523-PH , PTEN induced putative kinase 1 , PTEN-Induced kinase 1 , Pink1-PA , Pink1-PB , Pink1-PC , Pink1-PD , Pink1-PE , Pink1-PF , Pink1-PG , Pink1-PH , PTEN-induced putative kinase 1 , serine/threonine-protein kinase PINK1, mitochondrial , serine/threonine-protein kinase PINK1, mitochondrial-like , PTEN-induced putative kinase protein 1 , protein kinase BRPK

GENE ID SPEZIES
31607 Drosophila melanogaster
425370 Gallus gallus
494085 Danio rerio
510683 Bos taurus
706037 Macaca mulatta
749028 Pan troglodytes
100027082 Monodelphis domestica
100412264 Callithrix jacchus
100443445 Pongo abelii
100465867 Ailuropoda melanoleuca
65018 Homo sapiens
68943 Mus musculus
298575 Rattus norvegicus
Ausgewählte Anbieter für PINK1 Proteine (PINK1)
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