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This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. Zusätzlich bieten wir Ihnen PRDM2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal PRDM2 Primary Antibody für ChIP, WB - ABIN387783
Lakshmikuttyamma, Takahashi, Pastural, Torlakovic, Amin, Garcia-Manero, Voralia, Czader, DeCoteau, Geyer: RIZ1 is potential CML tumor suppressor that is down-regulated during disease progression. in Journal of hematology & oncology 2009
Show all 2 Pubmed References
Promoter region methylation of RIZ1 may play an important role in the epigenetic silencing of RIZ1 expression in pituitary adenomas, which may translate into important diagnostic and therapeutic applications
RIZ1 expression is negatively correlated with glioma differentiation and can serve as a predictor of glioma prognosis and thus could be a potential therapeutic target for patients with gliomas.
Loss of RIZ1 expression due to methylation is associated with Renal Cell Carcinoma (zeige MOK Antikörper).
PRDM2 downregulation may play a role in dopamine-agonist resistance and tumor recurrence in prolactinomas.
Results suggest that high expression of SMYD3 (zeige SMYD3 Antikörper) is related to the occurrence of esophageal squamous cell carcinoma. Also, its suppression promoted the expression of RIZ1 suggesting a signal transduction pathway between SMYD3 (zeige SMYD3 Antikörper) and RIZ1.
PRDM2, PRDM5 (zeige PRDM5 Antikörper), PRDM16 (zeige PRDM16 Antikörper) promoters are methylated and their expression is suppressed in lung cancer cells.
The development and progression of esophageal squamous cell carcinoma are related to the inactivation of RIZ1.
RIZ1 expression is significantly downregulated as the formation of meningiomas progressed, and suggest that RIZ1 may represent a promising candidate tumor suppressor gene that contributes to malignant meningiomas.
Reduction of RIZ1 expression aggravates the progression of liver fluke-related cholangiocarcinoma
Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype
RIZ1 is an important regulator of both Akt3 (zeige AKT3 Antikörper) transcription and AKT (zeige AKT1 Antikörper) phosphorylation and suggest a role for RIZ1 in HF-induced obesity and the AKT (zeige AKT1 Antikörper) pathway
RIZ1 might participate osteoclast formation through the regulation of NFATc1 (zeige NFATC1 Antikörper) expression.
Data suggest that the histone methyltransferase RIZ1 is required for estrogen response in female reproductive tissues and that estrogen-bound estrogen receptors may turn a transcriptional repressor into a coactivator.
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
PR domain containing 2, with ZNF domain
, retinoblastoma protein-binding zinc finger protein-like
, PR domain zinc finger protein 2-like
, GATA-3 binding protein G3B
, GATA-3-binding protein G3B
, MTE-binding protein
, PR domain zinc finger protein 2
, PR domain-containing protein 2
, lysine N-methyltransferase 8
, retinoblastoma protein-binding zinc finger protein
, retinoblastoma protein-interacting zinc finger protein
, zinc finger protein RIZ
, zinc-finger DNA-binding protein
, retinoblastoma interacting zinc finger protein