PITPNM Family Member 3 Proteine (PITPNM3)

PITPNM3 encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. Zusätzlich bieten wir Ihnen PITPNM Family Member 3 Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PITPNM3 83394 Q9BZ71
PITPNM3 327958 Q3UHE1
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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PITPNM3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu PITPNM Family Member 3 (PITPNM3) Interaktionspartnern

Human PITPNM Family Member 3 (PITPNM3) Interaktionspartner

  1. CCL18 can increase the invasive ability of non-small cell lung cancer cells by binding to its receptor Nir1.

  2. CCL18 (zeige CCL18 Proteine) enhances hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) cell migration, invasion, and epithelial-mesenchymal transition (EMT (zeige ITK Proteine)) through the expression of PITPNM3 and the activation of the NF-kappaB (zeige NFKB1 Proteine) signaling pathway.

  3. Data indicate that PYK2 N-terminal domain interacting receptor 1 (Nir1) could induce epithelial-mesenchymal transition by stabilising Snail (zeige SNAI1 Proteine) via the PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine)/GSK3beta/Snail (zeige SNAI1 Proteine) signalling pathway through binding to CCL18 (zeige CCL18 Proteine).

  4. Our observations of the PITPNM3 p.Q626H mutation carriers confirm that CORD5 (zeige GUCY2D Proteine) is a disease not to mix with other retinal degenerations mapped to 17p13.

  5. CCL18 (zeige CCL18 Proteine) derived from Tumor-associated macrophages (TAMs) lays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.

  6. Thus, mutations in PITPNM3 do not appear to be a major cause of cone or cone-rod dystrophy.

  7. Our finding on the first mutation in the human homologue of Drosophila rdgB (zeige PITPNM1 Proteine) indicates novel pathways and a potential important role of the PITPNM3 in mammalian phototransduction.

  8. Mutation in the PYK2 (zeige PTK2B Proteine)-binding domain of PITPNM3 causes autosomal dominant cone dystrophy (CORD5 (zeige GUCY2D Proteine)) in two Swedish families.

PITPNM Family Member 3 (PITPNM3) Protein Überblick

Protein Überblick

This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PITPNM3

  • PITPNM family member 3 (PITPNM3)
  • PITPNM family member 3 (Pitpnm3)
  • A330068P14Rik Protein
  • Ackr6 Protein
  • AI848332 Protein
  • CORD5 Protein
  • Gm880 Protein
  • NIR1 Protein
  • RDGBA3 Protein

Bezeichner auf Proteinebene für PITPNM3

NIR-1 , PITPnm 3 , PYK2 N-terminal domain-interacting receptor 1 , atypical chemokine receptor 6 , cone rod dystrophy 5 , membrane-associated phosphatidylinositol transfer protein 3 , phosphatidylinositol transfer protein, membrane-associated 3 , retinal degeneration B alpha 3 , pyk2 N-terminal domain-interacting receptor 1

GENE ID SPEZIES
83394 Homo sapiens
327958 Mus musculus
489445 Canis lupus familiaris
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