PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae) Proteine (PIF1)

PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT\; MIM 187270), a reverse transcriptase that maintains telomere length (Zhang et al., 2006 [PubMed 16522649]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae) Antikörper (18) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PIF1 80119 Q9H611
PIF1 367645 Q1HG60
PIF1 208084 Q80SX8
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.661,43 €
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PIF1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Rat (Rattus)

Mouse (Murine)

Weitere Proteine zu PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae) (PIF1) Interaktionspartnern

Human PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae) (PIF1) Interaktionspartner

  1. Structural and functional characterization of the unwinding mechanism of Bacteroides and human Pif1 helicases has been reported.

  2. Authors characterised a functional role for human PIF1 in DNA replication that becomes important for cell growth under oncogenic stress.

  3. Pif1 readily unfolds a parallel quadruplex DNA substrate in a multiturnover reaction and also generates some product under single cycle conditions

  4. A minimum of 10 oligonucleotide bases are required for PIF1 binding and the hydrolysis of ATP.

  5. the yeast ortholog of Pif1 appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP.

  6. Evidence that the PIF1 N-terminal (PINT) domain as crucial functions in PIF1 helicase.

  7. when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening

  8. PIF1 variant L319P was identified in three breast cancer families

  9. Findings suggest roles for PIF1 in S-phase entry and progression that are essential to protect human tumor cells from apoptosis.

  10. Human Pif1 could have a role in processing G4 structures that arise in the single-stranded nucleic acid intermediates formed during DNA replication and gene expression.

Mouse (Murine) PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae) (PIF1) Interaktionspartner

  1. pif1-/- animals develop a mitochondrial myopathy with respiratory chain deficiency.

  2. murine cells have evolved mechanisms to ensure the functional redundancy of Pif1 or Nbs1 (zeige NBN Proteine) in the regulation of chromosome healing.

  3. Murine telomere homeostasis or genetic stability does not depend on mPif1 (zeige CCL23 Proteine).

PIF1 5'-To-3' DNA Helicase Homolog (S. Cerevisiae) (PIF1) Protein Überblick

Protein Überblick

PIF1 is a 5-prime-to-3-prime DNA helicase that negatively regulates telomerase (see TERT\; MIM 187270), a reverse transcriptase that maintains telomere length (Zhang et al., 2006

Genbezeichner und Symbole assoziert mit PIF1

  • PIF1 5'-to-3' DNA helicase (PIF1)
  • PIF1 5'-to-3' DNA helicase (Pif1)
  • PIF1 5'-to-3' DNA helicase (pif1)
  • PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) (Pif1)
  • PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) (pif1)
  • 4631410M14 Protein
  • AI449441 Protein
  • C15orf20 Protein
  • cb934 Protein
  • fe11d03 Protein
  • PIF Protein
  • wu:fe11d03 Protein
  • zgc:56161 Protein

Bezeichner auf Proteinebene für PIF1

ATP-dependent DNA helicase PIF1 , DNA helicase PIF1 , DNA helicase homolog PIF1 , PIF1 5'-to-3' DNA helicase homolog , PIF1 DNA helicase , PIF1/RRM3 DNA helicase-like protein , petite integration frequency 1 , Pif1/Rrm3 DNA-helicase-like protein , DNA helicase-like protein , PIF1 homolog , Pif1/Rrm3 DNA helicase-like protein

GENE ID SPEZIES
80119 Homo sapiens
367645 Rattus norvegicus
734585 Xenopus laevis
208084 Mus musculus
326729 Danio rerio
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