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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Zusätzlich bieten wir Ihnen PDZ Binding Kinase Antikörper (142) und PDZ Binding Kinase Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.
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TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.
Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.
PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.
A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.
findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC
TOPK silencing sensitizes EGFR (zeige EGFR ELISA Kits)-TKI-resistant lung cancer cells to gefitinib and increases gefitinib efficacy in preclinical lung adenocarcinoma xenograft models.
Study shows that BUB1beta (zeige BUB1B ELISA Kits) and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Overexpression of Nrf2 (zeige GABPA ELISA Kits) inhibited the PBK/TOPK KD-induced decrease in cdc2 (zeige CDK1 ELISA Kits) and cyclin B expression and cell cycle arrest, and blocked ROS (zeige ROS1 ELISA Kits) production and apoptosis.
The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.
TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer
this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (zeige AKT1 ELISA Kits) signaling pathway
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (zeige DUSP1 ELISA Kits) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (zeige RNF19A ELISA Kits) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog