PAP Associated Domain Containing 4 Proteine (PAPD4)

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Zusätzlich bieten wir Ihnen PAP Associated Domain Containing 4 Antikörper (29) und PAP Associated Domain Containing 4 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PAPD4 167153 Q6PIY7
PAPD4 100715 Q91YI6
Ratte PAPD4 PAPD4 361878 Q5U315
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.207,46 €
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.223,17 €
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PAPD4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu PAP Associated Domain Containing 4 (PAPD4) Interaktionspartnern

Human PAP Associated Domain Containing 4 (PAPD4) Interaktionspartner

  1. our results propose a novel feedback regulatory mechanism for controlling HCV RNA abundance by the viral capsid protein, which is capable of modulating miR (zeige MLXIP Proteine)-122 activity and stability through the inhibition of GLD-2.

  2. QKI (zeige QKI Proteine)-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.

  3. HBx is a critical protein derived from HBV, which regulates miR (zeige MLXIP Proteine)-122 via down-regulating Gld2

  4. The noncanonical polymerase Gld2 has been implicated in the stabilization of miR (zeige MLXIP Proteine)-122, possibly through catalyzing 3' monoadenylation

  5. Study identified TUT7, TUT4 (zeige ZCCHC11 Proteine), and TUT2 as novel components of the miRNA biogenesis pathway.

  6. poly(A) polymerase (zeige PAPOLA Proteine) Gld2, deadenylase PARN (zeige PARN Proteine), and translation inhibitory factor neuroguidin (Ngd (zeige NGDN Proteine)) are components of a dendritic CPEB (zeige CPEB1 Proteine)-associated polyadenylation apparatus

  7. human CPE-binding protein 1 (zeige CPEB1 Proteine) and hGLD-2 are antagonizing factors regulating p53 (zeige TP53 Proteine) mRNA stability.

  8. The authors show that the human CPEB1 (zeige CPEB1 Proteine) can repress the activity of the reporter construct containing the HPV-16 early sequences. This repression can be counteracted by a human cytoplasmic poly(A) polymerase, hGLD-2 fused to CPEB1 (zeige CPEB1 Proteine).

Mouse (Murine) PAP Associated Domain Containing 4 (PAPD4) Interaktionspartner

  1. In Gld2 knockout mice there are detectable alterations in specific miRNA monoadenylation in the hippocampus, but no detectable effect on miRNA stability and no overt change in animal behavior.

  2. poly(A) polymerase (zeige PAPOLA Proteine) Gld2, deadenylase PARN (zeige PARN Proteine), and translation inhibitory factor neuroguidin (Ngd (zeige NGDN Proteine)) are components of a dendritic CPEB (zeige CPEB1 Proteine)-associated polyadenylation apparatus

  3. We found an association of mGLD-2 with cytoplasmic polyadenylation components, CPEB (zeige CPEB1 Proteine) and CPSF (zeige CPSF2 Proteine) described in Xenopus oocytes

  4. mGLD-2 may act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation.

  5. identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3'-terminal adenylation of miR (zeige MLXIP Proteine)-122 after unwinding of the miR (zeige MLXIP Proteine)-122/miR (zeige MLXIP Proteine)-122* duplex

Caenorhabditis elegans (C. elegans) PAP Associated Domain Containing 4 (PAPD4) Interaktionspartner

  1. investigate whether the functions of the cytoplasmic poly(A) polymerase (cytoPAP) GLD-2 in C. elegans germ cells exclusively depend on its catalytic activity; findings highlight the enzymatic importance of noncanonical poly(A) polymerases and emphasize the pivotal role of poly(A) tail-centered cytoplasmic mRNA regulation in germ cell biology.

  2. GLD-2 thus appears to have evolved specialized nucleotidyl-transferase properties that match the 3' end features of dormant cytoplasmic mRNAs

  3. The analyses suggest that GLD-2 activity mediates mRNA stability of many translationally repressed mRNAs.

  4. Data suggest that the FBF-2/GLD-2 protein directed polyadenylation of the endogenous mRNA, compensating for that mRNA's natural deadenylation.

  5. Data suggest that the GLD-2/RNP (zeige RNPC3 Proteine)-8 enzyme is a broad-spectrum regulator of the oogenesis program that acts within an RNA regulatory network to specify and produce fully functional oocytes.

  6. Regulates Gld-1 messenger RNA in germ cells, enabling the transition from mitosis to meiosis.

  7. FBF can affect polyadenylation either negatively by its CCF-1 interaction or positively by its GLD-2 interaction in control of GLD1 expression.

  8. GLD-4 is predominantly expressed in germ cells, and its activity is essential for early meiotic progression of male and female gametes in the absence of GLD-2

  9. In C. elegans hermaphrodites, gamete production begins with spermatogenesis and transitions later to oogenesis; the combinatorial use of GLD-2 contributes to this transition, as GLD-2/GLD-3 promotes spermatogenesis, and GLD-2/RNP (zeige RNPC3 Proteine)-8 specifies oogenesis.

PAP Associated Domain Containing 4 (PAPD4) Protein Überblick

Protein Überblick

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germ line.

Genbezeichner und Symbole assoziert mit PAPD4

  • PAP associated domain containing 4 (PAPD4)
  • PAP associated domain containing 4 (Papd4)
  • PAP associated domain containing 4 (papd4)
  • Protein GLD-2 (gld-2)
  • 8030446C20Rik Protein
  • AI649009 Protein
  • GLD-2 Protein
  • Gld2 Protein
  • zgc:110560 Protein

Bezeichner auf Proteinebene für PAPD4

PAP-associated domain-containing protein 4 , TUTase 2 , hGLD-2 , poly(A) RNA polymerase GLD2 , terminal uridylyltransferase 2 , cytoplasmic poly(A) polymerase , mGLD-2 , TUTase2

GENE ID SPEZIES
167153 Homo sapiens
607764 Canis lupus familiaris
533862 Bos taurus
100715 Mus musculus
361878 Rattus norvegicus
553626 Danio rerio
172338 Caenorhabditis elegans
Ausgewählte Anbieter für PAP Associated Domain Containing 4 Proteine (PAPD4)
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