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Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. Zusätzlich bieten wir Ihnen OSCAR Kits (26) und OSCAR Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 70 products:
Mouse (Murine) Monoclonal OSCAR Primary Antibody für WB - ABIN4236088
Negishi-Koga, Gober, Sumiya, Komatsu, Okamoto, Sawa, Suematsu, Suda, Sato, Takai, Takayanagi: Immune complexes regulate bone metabolism through FcRγ signalling. in Nature communications 2015
Human Polyclonal OSCAR Primary Antibody für ELISA, WB - ABIN185592
Kim, Kim, Lee, Jin, Lee, Fisher, Kook, Kim, Choi, Kim: Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis. in The Journal of biological chemistry 2005
Data suggest that OSCAR is a collagen receptor (zeige ITGA2 Antikörper) that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12 (zeige TYROBP Antikörper)-deficient humans and mice.
PU.1 and MITF (zeige MITF Antikörper) transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6 (zeige MAP2K6 Antikörper)/p38 (zeige CRK Antikörper) signaling cascade.
the FcRgamma (zeige FCER1G Antikörper)-mediated signal transduction by OSCAR is involved in osteoclast differentiation
OSCAR but not TREM-2 (zeige TREM2 Antikörper) is involved in the positive feedback loop of the immunoreceptor-NFATc1 (zeige NFATC1 Antikörper) pathway during osteoclastogenesis
analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1 (zeige NFATC1 Antikörper), involving NFATc1 (zeige NFATC1 Antikörper)-mediated OSCAR expression and its subsequent activation of NFATc1 (zeige NFATC1 Antikörper), necessary for efficient differentiation of osteoclasts
The overexpression of PIAS3 (zeige PIAS3 Antikörper) attenuates osteoclast formation and down-regulates the expression of NFATc1 (zeige NFATC1 Antikörper) and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL (zeige TNFSF11 Antikörper)-mediated osteoclastogenesis.
Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI (zeige GP6 Antikörper) and LAIR-1 (zeige LAIR1 Antikörper).
OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes.
Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients.
endothelial cell-derived OSCAR was found to be involved in the STAT (zeige STAT1 Antikörper) signaling pathway and to affect monocyte adhesion.
OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 (zeige NFATC1 Antikörper)
hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response.
ligation of OSCAR promotes dendritic cell survival by an ERK (zeige EPHB2 Antikörper)- and PI3K (zeige PIK3CA Antikörper)-dependent pathway, linked to expression of the Bcl-2 (zeige BCL2 Antikörper) and Bcl-x(L (zeige BCL2L1 Antikörper)) antiapoptotic molecules
Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j (zeige LILRB1 Antikörper) receptor.
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
osteoclast associated, immunoglobulin-like receptor
, osteoclast associated, immunoglobulin-like receptor, isoform 4
, osteoclast-associated immunoglobulin-like receptor
, osteoclast-associated receptor OSCAR
, osteoclast associated receptor OSCAR-S1
, osteoclast associated receptor OSCAR-S2
, poly-Ig receptor 3
, polymeric immunoglobulin receptor 3
, osteoclast associated receptor