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Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Zusätzlich bieten wir Ihnen OAZ3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Mutations in the OAZ3 gene are not a common cause of male infertility.
antizyme expression requires programmed, ribosomal frameshifting
Results indicated that OAZ-t is essential for the formation of a rigid junction between the head and tail during spermatogenesis.
Ornithine decarboxylase catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. The ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. Antizyme expression is auto-regulated by polyamine-enhanced translational frameshifting. In contrast to antizymes 1 and 2, which are widely expressed throughout the body, the expression of this gene product (antizyme 3) is restricted to testis germ cells, and thus it is a possible candidate for heritable forms of human male infertility. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ornithine decarboxylase antizyme 3
, antizyme 3
, ODC-Az 3
, Oaz t
, ornithine decarboxylase antizyme in testis
, testis specific ornithine decarboxylase antizyme