anti-Organic Anion Transporter 3 (OAT3) Antikörper

OAT3 encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human OAT3 OAT3 9376 Q8TCC7
Anti-Maus OAT3 OAT3 19879 O88909
Anti-Ratte OAT3 OAT3 83500 Q9R1U7
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Weitere Antikörper gegen Organic Anion Transporter 3 Interaktionspartner

Human Organic Anion Transporter 3 (OAT3) Interaktionspartner

  1. SLC22A8 (zeige SLC22A8 Antikörper) variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

  2. Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (zeige KCNK3 Antikörper)/OAT3 (zeige SLC22A8 Antikörper).

  3. The putative promoter sequences from hOAT1 (SLC22A6 (zeige SLC22A6 Antikörper)) and hOAT3 (zeige SLC22A8 Antikörper) (SCL22A8) were cloned into a reporter plasmid.

  4. PPIs inhibit [(3)H]MTX (zeige MTX1 Antikörper) transport via hOAT3 (zeige SLC22A8 Antikörper) inhibition.

  5. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 (zeige SLC22A8 Antikörper) in lymphoma cells and the high affinity of bendamustine for this transporter.

  6. Pemetrexed is a superior substrate to methotrexate for hOAT3 (zeige SLC22A8 Antikörper).

  7. In HEK293-Flp (zeige HPD Antikörper)-In cells, the OAT3 (zeige SLC22A8 Antikörper)-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 (zeige SLC22A8 Antikörper) [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].

  8. The results confirmed that OAT1 (zeige KCNK3 Antikörper), OAT3 (zeige SLC22A8 Antikörper), OCT2, MATE1 (zeige SLC47A1 Antikörper), and MATE2-K (zeige SLC47A2 Antikörper) were coexpressed in tubular epithelial cells.

  9. transport of xanthurenic acid by OAT1 (zeige KCNK3 Antikörper) and OAT3 (zeige SLC22A8 Antikörper)

  10. Both hOAT1 (zeige SLC22A6 Antikörper) and hOAT3 (zeige SLC22A8 Antikörper) markedly stimulated the uptake of kynurenic acid into oocytes.

Mouse (Murine) Organic Anion Transporter 3 (OAT3) Interaktionspartner

  1. OAT1 (zeige SLC22A6 Antikörper) plays a greater role in kidney proximal tubule metabolism and OAT3 (zeige SLC22A8 Antikörper) appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney

  2. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (zeige SLC22A6 Antikörper) and OAT3 (zeige SLC22A8 Antikörper)).

  3. Specifically blocking its transport through OAT3 (zeige SLC22A8 Antikörper) or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  4. Oat3 (zeige SLC22A8 Antikörper) also plays a role in bioenergetic pathways.

  5. At the protein level, mOat3 (zeige SLC22A8 Antikörper) and mOat1 (zeige SLC22A6 Antikörper) exhibit sex-dependent expression with an opposite pattern; mOat3 (zeige SLC22A8 Antikörper) is female dominant due to androgen inhibition, while mOat1 (zeige SLC22A6 Antikörper) is male dominant due to androgen stimulation.

  6. The results are consistent with a contribution of OAT3 (zeige SLC22A8 Antikörper) and possibly OAT1 (zeige SLC22A6 Antikörper) to renal creatinine secretion in mice.

  7. DAT (zeige SLC6A3 Antikörper) and Oct3 (zeige POU5F1 Antikörper) modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling

  8. functional differences in the relative importance of OAT1 (zeige SLC22A6 Antikörper) and OAT3 (zeige SLC22A8 Antikörper) in antiviral handling in developing and mature tissue

  9. the ontogenic pattern of expression of OAT1 (zeige SLC22A6 Antikörper) and OAT3 (zeige SLC22A8 Antikörper) in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus

  10. Oat3 (zeige SLC22A8 Antikörper) plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 (zeige SLC22A8 Antikörper) = SLC22A8 (zeige SLC22A8 Antikörper) transporter)

Organic Anion Transporter 3 (OAT3) Antigen-Profil

Protein Überblick

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit OAT3

  • solute carrier family 22 (organic anion transporter), member 8 (SLC22A8) Antikörper
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8) Antikörper
  • Oat3 Antikörper
  • OCT3 Antikörper
  • Roct Antikörper

Bezeichner auf Proteinebene für OAT3

hOAT3 , organic anion transporter 3 , solute carrier family 22 member 8 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3

9376 Homo sapiens
19879 Mus musculus
83500 Rattus norvegicus
404128 Bos taurus
100008845 Oryctolagus cuniculus
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