Opsin 4 Proteine (OPN4)

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. Zusätzlich bieten wir Ihnen OPN4 Antikörper (22) und OPN4 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte OPN4 OPN4 192223 Q8R456
OPN4 94233 Q9UHM6
OPN4 30044 Q9QXZ9
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
Details

OPN4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)
,

Weitere Proteine zu Opsin 4 (OPN4) Interaktionspartnern

Zebrafish Opsin 4 (OPN4) Interaktionspartner

  1. Melanopsin photostimulation triggers the phosphoinositide pathway through activation of a G-Protein, G11 (zeige STK19 Proteine).

  2. The opn4a gene is expressed continuously from 1 to 3 dpf in the presumptive preoptic area, as defined by coexpression of the orthopedia homolog (otp) gene.

  3. description of the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that vertebrates have evolved two quite separate melanopsins

Turkey Opsin 4 (OPN4) Interaktionspartner

  1. Expressed locally in the premammillary nucleus of the hypothalamus in temperate zone birds, melanopsin is an important regulator of reproductive activity.

Human Opsin 4 (OPN4) Interaktionspartner

  1. Trait-like individual differences in the melanopsin phototransduction circuitry contribute to individual differences in sleep timing. Blue light-sensitive young individuals are more prone to delayed sleep.

  2. The light-induced FOS response in melanopsin expressing HEK (zeige EPHA3 Proteine)-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.

  3. By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration.

  4. The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured.

  5. Studied OPN4*Ile394Thr gene polymorphism in association with sleep/wake timing.

  6. The results of this study showed that the post illumination pupil response varied on the basis of OPN4 I394T genotype among individuals with seasonal affective disorder.

  7. Studied the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths.

  8. A comparison of melanopsin with the mechanisms documented for vertebrate (bovine) and invertebrate (squid) visual photoreceptors shows that such a mechanism is not affected by the diversity of the three chromophore cavities.

  9. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin (zeige RHO Proteine) : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents.

  10. the results indicate that ectopic expression of human OPN4 in orexin neurons enables long-lasting activation of orexin neurons by blue light to control sleep/wakefulness of the mice.

Mouse (Murine) Opsin 4 (OPN4) Interaktionspartner

  1. Melanopsin contributes to irradiance modulation of narrowband oscillations in the retina and dorsal lateral geniculate nucleus.

  2. discovery that amino acid sequence features of melanopsin protein contribute to the functional properties of the intrinsically photosensitive retinal ganglion cells

  3. When compared with wildtype responses, sleep onset in melanopsin (OPN4-/-) mice was significantly advanced under blue light, whereas under violet and green light it was significantly delayed.

  4. Melanopsin overexpression in RGCs enhanced the amplitude and duration of their light response, and silencing them with Kir2.1 (zeige KCNJ2 Proteine) significantly suppressed the increased mTOR (zeige FRAP1 Proteine) signaling and axon regeneration that were induced by melanopsin

  5. mice null for melanopsin (Opn4-/-), lost significantly more weight than wild-type controls or mice lacking rod and cone photoreceptors.

  6. These results suggest GRK2 (zeige ADRBK1 Proteine) contributes to melanopsin deactivation, but that other mechanisms account for most of modulation of melanopsin activity in ipRGCs.

  7. Using a combination of conventional knockout, chemogenetic, and receptor-silent substitution manipulations, we continued to show that, over higher irradiances, this increase in firing originates with inner-retinal melanopsin photoreception

  8. Opn4 mediates wavelength-specific, light-dependent vascular relaxation.

  9. Data indicate that retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment.

  10. critical phosphorylation sites on the carboxy tail of melanopsin

OPN4 Protein Überblick

Protein Überblick

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit Opsin 4 Proteine (OPN4)

  • opsin 4.1 (opn4.1)
  • opsin 4 (OPN4)
  • melanopsin (LOC100303707)
  • melanopsin-B-like L homeolog (LOC100485437.L)
  • opsin 4a (melanopsin) (opn4a)
  • opsin 4 (Opn4)
  • opsin 4 (melanopsin) (Opn4)
  • 1110007J02Rik Protein
  • cOpn4L Protein
  • Gm533 Protein
  • melanopsin Protein
  • MOP Protein
  • opn4 Protein
  • OPN4-2 Protein
  • opn4-A Protein
  • opn4d Protein
  • opn4l Protein
  • opn4m2 Protein
  • Xmop Protein

Bezeichner auf Proteinebene für Opsin 4 Proteine (OPN4)

melanopsin opn4m2 , melanopsin-like , opn4c , opsin 4 (melanopsin) , opsin 4, like , melanopsin , melanopsin 2 , opsin 4 like , putative Opsin 4 , opsin 4 , putative photopigment melanopsin , mammalian-like melanopsin , melanopsin opn4m1 , melanopsin-A , melanopsin-M , opn4m1 , opsin-4-A , opsin-4M , opsin-4

GENE ID SPEZIES
352918 Danio rerio
423609 Gallus gallus
515152 Bos taurus
611027 Canis lupus familiaris
735531 Pan troglodytes
100303707 Meleagris gallopavo
373689 Xenopus laevis
571624 Danio rerio
192223 Rattus norvegicus
94233 Homo sapiens
493921 Felis catus
30044 Mus musculus
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