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a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Opioid Receptor, kappa 1 Antikörper (134) und Opioid Receptor, kappa 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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ZFOR3 is a unique model to study kappa opioid receptor functionality
These findings provide evidence that previously demonstrated KOR-mediated reduction in intraocular pressure could be caused, in part, by NO production in both the ciliary body and the trabecular meshwork.
Functional activity of Dynorphin 1-17 and fragments (1-6, 1-7 and 1-9) were screened over a range of concentrations against forskolin stimulated human embryonic kidney 293 (HEK (zeige EPHA3 Proteine)) cells stably transfected with one of KOP (zeige SPINT2 Proteine), MOP (zeige NLN Proteine) or DOP (zeige COPB2 Proteine)
These results indicate that KOR can form a heterodimer with B2R (zeige BDKRB2 Proteine) and this leads to increased protein kinase A activity by the CREB (zeige CREB1 Proteine) signaling pathway, leading to a significant increase in cell proliferation.
that promoter fragments of OPRK1 and OPRM1 (zeige OPRM1 Proteine) were able to upregulate gene expression with mild cognitive impairment
Heterodimerization of the kappa opioid receptor and neurotensin receptor 1 contributes to a novel beta-arrestin-2 (zeige ARRB2 Proteine)-signaling pathway.
Hypoxia inducible factor-1alpha (HIF-1alpha (zeige HIF1A Proteine)) siRNA knocked down the increase of endogenous HIF-1alpha (zeige HIF1A Proteine) messages and diminished the desferrioxamine (DFO)-induced increase of kappa-opioid receptor (hKOR) expression.
genetic association studies in a population in Denmark: Data suggest that carriers/heterozygotes of the C allele (CC/CT) of OPRK SNP rs6473799 report a 30.4% higher mechanical visceral pain tolerance threshold than non-carriers.
Molecular switches of the kappa opioid receptor triggered by 6'-GNTI (zeige MGAT1 Proteine) and 5'-GNTI (zeige MGAT1 Proteine) have been described.
The study successfully developed a population PKPD model for oxycodone across three experimental pain types and investigated the association between 18 SNPs across all three opioid receptor genes (OPRM1, OPRK1, OPRD1) and analgesic response from oxycodone. None of the selected polymorphisms were significantly associated with analgesic response of oxycodone.
findings suggest that SNPs in opioid receptors and the PNOC genes are associated with NAS (zeige SCN9A Proteine) severity.
OPRK1 promoter hypermethylation might increase the risk of AD through its regulation on the gene expression of OPRK1.
triazole 1.1 retained the antinociceptive and antipruritic efficacies of a conventional KOR agonist, yet it did not induce sedation or reductions in dopamine release in mice, nor did it produce dysphoria as determined by intracranial self-stimulation
This study reports a cluster of compounds that are highly effective in enhancing remyelination and identifies kappa-opioid receptor (KOR) as a positive regulator for oligodendroglial differentiation, implicating KOR agonism as a potential strategy to accelerate remyelination.
GRK2 (zeige ADRBK1 Proteine) upregulation causes kappa-opioid receptor desensitization in diabetic heart
Study showed that Dyn (zeige PDYN Proteine)-A, the endogenous kappa opioid receptor agonist, significantly hyperpolarized and inhibited neurons in the paraventricular nucleus of mouse thalamus
Suggest that mixed cardiac ion channel blockade my mediated the antiarrhythmia actions of kappa-opioid receptor antagonist PD117,302.
Anti-nociception mediated by a KOR agonist is blocked by a DOR agonist
Findings suggest that activation of kappa opioid receptor (kappa-opioid receptor) reduces hyperglycemia in streptozotocin-induced diabetic mice.
findings show that, during prolonged heroin abstinence, delta opioid receptors regulate hedonic homeostasis, while mu opioid receptor (zeige OPRM1 Proteine) signaling in serotonergic pathways and kappa opioid receptors together control social behaviors
kappa-Opioid receptor mediates the antinociceptive effect of nitrous oxide in mice.
The data of this study provide evidence that KORs on VTA DA neurons are necessary to mediate KOR-mediated aversive behavior.
a class of opioid receptors\; show selective affinity for the endogenous opioid dynorphin
, kappa-type opioid receptor
, opioid receptor, kappa 1
, kappa opioid receptor
, Opiate receptor, kappa-1
, opioid receptor, kappa 2