Oligophrenin 1 Proteine (OPHN1)

OPHN1 encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Zusätzlich bieten wir Ihnen Oligophrenin 1 Antikörper (16) und Oligophrenin 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
OPHN1 4983 O60890
OPHN1 94190 Q99J31
OPHN1 312108 P0CAX5
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Ratte T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
576,19 €
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HOST_Escherichia coli (E. coli) Maus T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
576,19 €
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OPHN1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

Weitere Proteine zu Oligophrenin 1 (OPHN1) Interaktionspartnern

Human Oligophrenin 1 (OPHN1) Interaktionspartner

  1. Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment

  2. Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase (zeige ROCK1 Proteine) inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets.

  3. we reported on the first male patient carrying an OPHN1 mutation with IQ score within the normal limits. This observation expands the phenotypic spectrum of OPHN1 mutations.

  4. A neuronal stem cell-based model for the treatment of OPHN1 syndrome and other neurological disorders due to ROCK dysfunction.

  5. results suggest that oligophrenin-1 is involved in tumor progression in prostate cancer

  6. This is the first description of an in-frame deletion within the BAR domain of OPHN1 and could provide new insights into the role of this domain in relation to brain and cognitive development or function.

  7. Our results demonstrate that multiple post-transcriptional events occur on OPHN1, a gene playing an important role in brain function and development.

  8. In response to GPVI (zeige GP6 Proteine) stimulation, OPHN1 becomes phosphorylated at Tyr370 and plays a role in the formation of filopodia during platelet spreading on collagen.

  9. Several genes expressed at exceptionally high levels were identified associated with early oocyte development, TMEFF2 (zeige TMEFF2 Proteine), the Rho-GTPase-activating protein (zeige STARD13 Proteine) oligophrenin 1 (OPHN1) and the mitochondrial-encoded ATPase6 (ATP6 (zeige MT-ATP6 Proteine)).

  10. This mutation determines the production of a mutant oligophrenin 1 protein with 16 extra amino acids inserted in-frame in the N-terminal BAR (Bin1 (zeige BIN1 Proteine)/amphiphysin (zeige AMPH Proteine)/Rvs167) domain. (oligophrenin 1 protein )

Mouse (Murine) Oligophrenin 1 (OPHN1) Interaktionspartner

  1. Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment

  2. Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase (zeige ROCK2 Proteine) inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets.

  3. OPHN1 mediated regulation of RhoA (zeige RHOA Proteine), Rac1 and Cdc42 (zeige CDC42 Proteine) is crucial for the preservation of cardiac function after myocardial injury.

  4. Identify OPHN1 as an important regulator of platelet cytoskeletal reorganization and thrombus formation.

  5. OPHN1 is a bifunctional protein that is able, through distinct mechanisms, to regulate and most likely link exocytosis to compensatory endocytosis in chromaffin cells.

  6. OPHN1 is a powerful regulator of Rho GTPase (zeige RACGAP1 Proteine) activity in platelets that is critical for the reorganization of the cytoskeleton, which is a major process required for stable platelet adhesion and thrombus formation to occur.

  7. Ophn1 is involved in processes of normal retinal vessel function during adulthood.

  8. our data establish a role for rapid OPHN1 synthesis in mGluR (zeige GRM8 Proteine) long-term depression.

  9. The results of this study indicated the presence of a circadian oscillator in the hippocampus, involving the clock gene Bmal1 (zeige ARNTL Proteine) (also known as Arntl (zeige ARNTL Proteine)), that is modulated by Rev-erbalpha (zeige NR1D1 Proteine) and requires oligophrenin-1 for normal oscillation.

  10. Oligophrenin-1 is expressed in developing CNS areas that evince synaptic plasticity. OPHN1 is expressed in both glial and neuronal cells, where it colocalizes with actin at the tip of growing neurites.

Cow (Bovine) Oligophrenin 1 (OPHN1) Interaktionspartner

  1. OPHN1 is a bifunctional protein that is able, through distinct mechanisms, to regulate and most likely link exocytosis to compensatory endocytosis in chromaffin cells.

Oligophrenin 1 (OPHN1) Protein Überblick

Protein Überblick

This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism.

Genbezeichner und Symbole assoziert mit Oligophrenin 1 Proteine (OPHN1)

  • oligophrenin-1-like (LOC100065450)
  • oligophrenin 1 (ophn1)
  • oligophrenin 1 (OPHN1)
  • oligophrenin 1 (Tsp_13482)
  • oligophrenin 1 (Ophn1)
  • oligophrenin-1-like (LOC525644)
  • ARHGAP41 Protein
  • C130037N19Rik Protein
  • MGC68856 Protein
  • MRX60 Protein
  • OPHN1 Protein
  • Opn1 Protein
  • zgc:92603 Protein

Bezeichner auf Proteinebene für Oligophrenin 1 Proteine (OPHN1)

oligophrenin 1 , oligophrenin-1 , mental retardation, X-linked 60 , oligophrenin-1, Rho-GTPase activating protein

GENE ID SPEZIES
100065450 Equus caballus
379682 Xenopus laevis
422162 Gallus gallus
436982 Danio rerio
703141 Macaca mulatta
710787 Macaca mulatta
779935 Xenopus (Silurana) tropicalis
10901254 Trichinella spiralis
100379222 Cavia porcellus
100554128 Anolis carolinensis
4983 Homo sapiens
94190 Mus musculus
312108 Rattus norvegicus
607363 Canis lupus familiaris
449628 Pan troglodytes
525644 Bos taurus
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