Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Proteine (OBFC1)

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). Zusätzlich bieten wir Ihnen Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Antikörper (48) und Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
OBFC1 79991 Q9H668
OBFC1 108689 Q8K2X3
Ratte OBFC1 OBFC1 294025 Q6AYD2
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 11 bis 15 Tage
387,62 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
523,81 €
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HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
285,71 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.248,89 €
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Hefe Lithobates catesbeiana His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.769,21 €
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Hefe REACT_Panda His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.861,74 €
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OBFC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Am meisten referenzierte Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Proteine

  1. Human OBFC1 Protein expressed in Escherichia coli (E. coli) - ABIN1098527 : Miyake, Nakamura, Nabetani, Shimamura, Tamura, Yonehara, Saito, Ishikawa: RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. in Molecular cell 2009 (PubMed)
    Zeige alle 2 Referenzen für 1098527

Weitere Proteine zu Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Interaktionspartnern

Human Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Interaktionspartner

  1. The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.

  2. TERT (zeige TERT Proteine)-mediated G-strand extension and Ctc1-Stn1 (zeige STON1 Proteine)-Ten1 (zeige TEN1 Proteine)-mediated C-strand fill-in are equally important for telomere length maintenance.

  3. Mutations in STN1 (zeige STON1 Proteine) cause Coats plus syndrome and are associated with genomic and telomere defects.

  4. The mammalian CST (zeige GAL3ST1 Proteine) (CTC1-STN1 (zeige STON1 Proteine)-TEN1 (zeige TEN1 Proteine)) complex is directly involved at several stages of telomere end formation and CST (zeige GAL3ST1 Proteine) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication.

  5. we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1). Interestingly, we observed that genetic variation does not account for LTL at birth

  6. A 2-SNP OBFC1 haplotype was associated with higher risk of CHD (zeige CHDH Proteine), and a 3-SNP TERC haplotype was associated with both higher risk of CHD (zeige CHDH Proteine) and T2D.

  7. The Stn1 deficiency leads to persistent and elevated association of DNA polymerase alpha to telomeres, suggesting that Stn1 may modulate the DNA synthesis activity of polalpha rather than controlling the loading of polalpha to telomeres.

  8. the requirement for STN1 (zeige STON1 Proteine)/CST (zeige GAL3ST1 Proteine) in telomere duplex replication correlates with increasing telomere length and replication stress.

  9. CTC1-STN1 (zeige STON1 Proteine)-TEN1 (zeige TEN1 Proteine) complex rescues stalled replication forks during conditions of replication stress, such as those found at natural replication barriers, likely by facilitating dormant origin firing

  10. the human CST (zeige GAL3ST1 Proteine) (CTC1, STN1 (zeige STON1 Proteine) and TEN1 (zeige TEN1 Proteine)) complex, previously implicated in telomere protection and DNA metabolism, inhibits telomerase activity through primer sequestration and physical interaction with the protection of telomeres 1 (POT1 (zeige POT1 Proteine))-TPP1 (zeige TPP1 Proteine) telomerase processivity factor

Mouse (Murine) Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Interaktionspartner

  1. OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.

Arabidopsis thaliana Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Interaktionspartner

  1. STN1 plays a genome-wide role in DNA replication and telomere stability.

  2. POT1a (zeige POT1 Proteine) promotes an extendable telomere state via contacts with the telomerase RNP (zeige RNPC3 Proteine) as well as STN1 and CTC1, while TEN1 (zeige TEN1 Proteine) opposes these functions.

  3. findings indicate that ATR and CST (zeige GAL3ST1 Proteine) (CTC1/STN1/TEN1 (zeige TEN1 Proteine)) act synergistically to maintain genome integrity and telomere length homeostasis

  4. AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)

  5. CTC1 participates in telomere maintenance in diverse species and that a CST (zeige GAL3ST1 Proteine)-like complex is required for telomere integrity in multicellular organisms.

Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Protein Überblick

Protein Überblick

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009

Genbezeichner und Symbole assoziert mit OBFC1

  • oligonucleotide/oligosaccharide-binding fold containing 1 (OBFC1)
  • oligonucleotide/oligosaccharide-binding fold containing 1 (Obfc1)
  • oligonucleotide/oligosaccharide-binding fold containing 1 (obfc1)
  • STN1-like protein (STN1)
  • 0610009H20Rik Protein
  • 2310057J23Rik Protein
  • AAF-44 Protein
  • AAF44 Protein
  • AI413458 Protein
  • ATSTN1 Protein
  • bA541N10.2 Protein
  • F10K1.17 Protein
  • F10K1_17 Protein
  • RP11-541N10.2 Protein
  • RPA-32 Protein
  • STN1 Protein
  • zgc:64174 Protein

Bezeichner auf Proteinebene für OBFC1

CST complex subunit STN1 , alpha accessory factor 44 , oligonucleotide/oligosaccharide-binding fold-containing protein 1 , replication protein A 32 kDa subunit , suppressor of cdc thirteen homolog , alpha-accessory factor of 44 kDa

GENE ID SPEZIES
79991 Homo sapiens
108689 Mus musculus
294025 Rattus norvegicus
514213 Bos taurus
393360 Danio rerio
837223 Arabidopsis thaliana
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