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Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Zusätzlich bieten wir Ihnen Obg-Like ATPase 1 Antikörper (82) und Obg-Like ATPase 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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No germline mutations were found in the OLA1 gene in in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer.
OLA1 contributes to epithelial-mesenchymal transition by modulating the GSK3beta/Snail (zeige SNAI1 Proteine)/E-cadherin (zeige CDH1 Proteine) signaling, and its overexpression is associated with clinical progression and poor survival in lung cancer patients.
Our work suggests that OLA1 is a novel translational GTPase (zeige RACGAP1 Proteine) and plays a suppressive role in translation and cell survival, as well as cancer growth and progression.
OLA1 plays an important negative role in cell adhesion and spreading, in part through the regulation of FAK (zeige PTK2 Proteine) expression and cofilin (zeige CFL1 Proteine) phosphorylation, and manipulation of OLA1 may lead to significant changes in cell adhesion and the associated phenotypes.
OLA1 plays an important role in centrosome regulation together with BRCA1.
Downregulation of OLA1 in mammalian cells by either RNAi or targeted gene disruption results in reduced steady-state levels of HSP70 (zeige HSP70 Proteine), impaired HSP70 (zeige HSP70 Proteine) induction by heat, and functionally, increased cellular sensitivity to heat shock.
DOC45 is a novel ATPase that is linked to cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker.
knockdown of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS (zeige ROS1 Proteine) levels
Results indicate that Gbp45/OLA1 plays important roles in cell proliferation and death related to mitochondrial function.
OLA1 suppresses the antioxidant response through nontranscriptional mechanisms.
Data demonstrate that OLA1 is required for normal progression of mammalian development. OLA1 plays an important role in promoting cell proliferation at least in part through suppression of p21 and organogenesis via factors yet to be discovered.
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity).
obg-like ATPase 1
, Obg-like ATPase 1
, GTP-binding protein PTD004
, GTP-binding protein 9 (putative)
, DNA damage-regulated overexpressed in cancer 45 protein
, homologous yeast-44.2 protein