OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) Proteine (OMA1)

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Zusätzlich bieten wir Ihnen OMA1 Antikörper (8) und OMA1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte OMA1 OMA1 298282 D3ZS74
OMA1 67013 Q9D8H7
OMA1 115209 Q96E52
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
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OMA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) Interaktionspartnern

Mouse (Murine) OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) Interaktionspartner

  1. The m-AAA (zeige AAAS Proteine) protease associated with neurodegeneration limits MCU (zeige MCU Proteine) activity in mitochondria.

  2. stress-induced OMA1 activation and guanosine triphosphatase OPA1 cleavage limit mitochondrial fusion and promote neuronal death

  3. The IMQC protease Oma1 is required for the stability of the respiratory supercomplexes and thus balanced and tunable bioenergetic function.

  4. OMA1-mediated OPA1 proteolysis plays an important role in the disruption of mitochondrial dynamics in ischemic acute kidney injury.

  5. Constitutive OPA1 cleavage by YME1L (zeige YME1L1 Proteine) and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion.

  6. Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.

  7. This study shows that OMA1 plays an essential role in the proteolytic inactivation of the dynamin (zeige DNM1 Proteine)-related GTPase (zeige RACGAP1 Proteine) OPA1 and describes its unexpected role in energy metabolism

  8. OMA1 regulates OPA1 cleavage in the mitochondrial inner membrane.

Human OMA1 Zinc Metallopeptidase Homolog (S. Cerevisiae) (OMA1) Interaktionspartner

  1. differential stress-induced degradation of YME1L (zeige YME1L1 Proteine) and OMA1 as a mechanism for sensitively adapting mitochondrial inner membrane protease activity and function in response to distinct types of cellular insults.

  2. The mitochondrial metalloprotease OMA1 was activated in a Bax (zeige BAX Proteine)- and Bak (zeige BAK1 Proteine)-dependent fashion.

  3. Cleavage of the inner membrane fusion factor L-OPA1 (zeige OPA1 Proteine) is prevented due to the failure to activate the inner membrane protease OMA1 in mitochondria that have a collapsed membrane potential.

  4. OMA1 is cleaved to a short form (S-OMA1) by itself upon mitochondrial membrane depolarization; S-OMA1 is degraded quickly but could be stabilized by CCCP treatment or Prohibitin (zeige PHB Proteine) knockdown in cells.

  5. These findings demonstrate that (a) p53 (zeige TP53 Proteine) and Oma1 mediate L-Opa1 (zeige OPA1 Proteine) processing, (b) mitochondrial fragmentation is involved in CDDP-induced apoptosis in OVCA and CECA cells, and (c) dysregulated mitochondrial dynamics

  6. OMA1 controls OPA1 (zeige OPA1 Proteine) cleavage and function.

  7. These results provide evidence for different substrate specificities of m-AAA (zeige APP Proteine) proteases composed of different subunits and reveal a striking evolutionary switch of proteases involved in the proteolytic processing of dynamin (zeige DNM1 Proteine)-like GTPases in mitochondria.

OMA1 Protein Überblick

Protein Überblick

Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity).

Genbezeichner und Symbole assoziert mit OMA1

  • OMA1 zinc metallopeptidase (Oma1)
  • OMA1 zinc metallopeptidase (OMA1)
  • 2010001O09Rik Protein
  • DAB1 Protein
  • MPRP-1 Protein
  • peptidase Protein
  • RGD1304821 Protein
  • YKR087C Protein
  • ZMPOMA1 Protein

Bezeichner auf Proteinebene für OMA1

OMA1 homolog, zinc metallopeptidase , metalloendopeptidase OMA1, mitochondrial , overlapping with the m-AAA protease 1 homolog , OMA1 zinc metallopeptidase homolog , metalloprotease related protein 1 , metalloprotease-related protein 1 , overlapping activity with M-AAA protease , zinc metallopeptidase OMA1

GENE ID SPEZIES
298282 Rattus norvegicus
506223 Bos taurus
67013 Mus musculus
115209 Homo sapiens
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