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RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis.
Data indicate that disease in NAF1 (zeige TNIP1 Proteine) mutation carriers is telomere-mediated; they show that NAF1 (zeige TNIP1 Proteine) haploinsufficiency selectively disturbs telomere length homeostasis by decreasing the levels of telomerase RNA while sparing rRNA pseudouridylation.
Naf1 (zeige TNIP1 Proteine) contributes to the maintenance of HIV-1 latency by inhibiting long terminal repeat driven HIV-1 gene transcription in a nuclear factor kappa B-dependent manner.
RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity).
H/ACA ribonucleoprotein complex non-core subunit NAF1
, nuclear assembly factor 1 homolog