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NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal NSD1 Primary Antibody für ICC, IF - ABIN151269
Quintana, Dupuy, Bravo, Casanova, Alameda, Page, Sánchez-Viera, Ramírez, Navarro: A transposon-based analysis of gene mutations related to skin cancer development. in The Journal of investigative dermatology 2013
Mammalian Monoclonal NSD1 Primary Antibody für ISt, IHC - ABIN1304874
Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014
Human Monoclonal NSD1 Primary Antibody für ELISA, WB - ABIN528606
Lu, Jackson, Wang, Yang, Chance, Miyagi, Gudkov, Stark: Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. in Proceedings of the National Academy of Sciences of the United States of America 2010
variable expression of the Sotos syndrome caused by NSD1 mutation
In this report, we described a new patient with Sotos syndrome caused by a 5q35 microdeletion spanning approximately 1.9 Mb in size and including the complete NSD1 gene
NSD1 Inactivation is associated with Clear Cell Renal Cell Carcinomas.
Nuclear receptor binding SET domain protein 1 (NSD1)duplication in 5q35 pathogenic variants could be detected in five out of 43 Silver-Russell syndrome (SRS (zeige SMS Antikörper)) patients.
Study illustrates the dynamic behavior of the post-SET loop and the presence of a few distinct conformations for NSD1 protein. In every case, the post-SET loop remains in an autoinhibitory position blocking the peptide-binding cleft, suggesting that another interaction is required to optimally position NSD1 in an active conformation.
NSD1 mutation is associated with severe connective tissue laxity including aortic dilatation in Sotos syndrome.
NSD1 mutation is associated with Hyperinsulinemic hypoglycemia.
Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET (zeige WHSC1 Antikörper) and NSD3/WHSC1L1 (zeige WHSC1L1 Antikörper) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
The genome-wide impact of a highly significant NSD1(+/-)-specific signature that differentiates pathogenic NSD1 mutations from controls, benign NSD1 variants and the clinically overlapping Weaver (zeige KCNJ6 Antikörper) syndrome is described.
The results describe the binding of NSD1, 2 and 3 catalytic domains CD) on histone tails through recognition of histone-lysine and methylation properties.
Silencing of Nsd1 followed by LLO stimulation led to increased caspase-1 (zeige CASP1 Antikörper) activation, enhanced post-translational maturation of IL-1beta (zeige IL1B Antikörper) and IL-18 (zeige IL18 Antikörper) and elevated pyroptosis, a form of cell death associated with inflammation.
Nsd1 contains consensus TFII-I (zeige GTF2I Antikörper) binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I (zeige GTF2I Antikörper) transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.
all of the H3K36-specific methyltransferases, including ASH1L (zeige ASH1L Antikörper), HYPB (zeige SETD2 Antikörper), NSD1, and NSD2 (zeige WHSC1 Antikörper) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (zeige EHMT2 Antikörper), and Pr-Set7 (zeige SETD8 Antikörper) were not affected by ubH2A.
NSD1 interaction with liganded NRs (zeige SPNS1 Antikörper) including ERa, AR, RARa (zeige RARA Antikörper), RXRa (zeige RXRA Antikörper), TRb (zeige AATF Antikörper), PPARg (zeige PPARG Antikörper) and VDR (zeige CYP27B1 Antikörper) is mediated by an LXXLL motif. Interaction with the NR2E/F subfamily including COUP-TFI (zeige NR2F1 Antikörper), COUP-TFII (zeige NR2F2 Antikörper), EAR2 (zeige NR2F6 Antikörper) and TLX (zeige NR2E1 Antikörper) requires an overlapping F/YSXXLXXL/Y motif.
Data show that nuclear receptor-binding SET domain-containing protein (NSD1) is a developmental regulatory protein with histone methyltransferase activity that exerts function(s) essential for early post-implantation development.
Nizp1 (zeige ZNF496 Antikörper) contains a novel type of zinc finger motif that functions as a docking site for NSD1
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.
nuclear receptor binding SET domain protein 1
, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like
, NR-binding SET domain-containing protein
, androgen receptor coactivator 267 kDa protein
, androgen receptor-associated coregulator 267
, androgen receptor-associated protein of 267 kDa
, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
, lysine N-methyltransferase 3B
, nuclear receptor-binding SET domain-containing protein 1