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NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. Zusätzlich bieten wir Ihnen NCF2 Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.
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analysis of NCF2, BCKDHB (zeige BCKDHB Proteine) and BCKDHA (zeige BCKDHA Proteine) in pig
We analyzed the clinical and laboratory findings of CGD (zeige CYBB Proteine) with mutations in the NCF2 gene from amongst our cohort of CGD (zeige CYBB Proteine) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.
All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.
Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (zeige NCF4 Proteine) and p67phox at the phagosomal membrane.
TLR4 (zeige TLR4 Proteine)- and TLR2-induced IRAK (zeige IRAK1 Proteine)-ERK (zeige EPHB2 Proteine) pathway cross-talks with p67phox-Nox-2 (zeige CYBB Proteine) for reactive oxygen species generation, thus regulating IL-1beta (zeige IL1B Proteine) transcription and processing in monocytic cells.
Skeletal muscle protein expression of the NADPH oxidase (zeige NOX1 Proteine) subunits p22(phox (zeige CYBA Proteine)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (zeige CYBA Proteine)) and p67(phox) expression was attenuated by exercise training in obese subjects.
A novel homozygous mutation in NCF2.
results reveal an essential role for the Cys (zeige DNAJC5 Proteine)-Gly-Cys (zeige DNAJC5 Proteine) triad in Nox2 (zeige CYBB Proteine) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (zeige DNAJC5 Proteine)-Gly-Cys (zeige DNAJC5 Proteine). The 2 regions interact with distinct partner sites in p67(phox).
This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (zeige NCF4 Proteine)/VAV1 (zeige VAV1 Proteine)/RAC1 NADPH oxidase (zeige NOX1 Proteine) complex.
Data indicate that arachidonic acid induces the direct interaction of Rac (zeige AKT1 Proteine)-GTP (zeige AK3 Proteine)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (zeige NOX1 Proteine) Nox2 (zeige CYBB Proteine).
Four novel mutations in the NCF1 (zeige NCF1 Proteine), NCF2, and CYBB (zeige CYBB Proteine) genees have been identified in chronic granulomatous disease patients in Morocco.
Just as patients with chronic granulomatous disease who lack NADPH oxidase (zeige NOX1 Proteine) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.
p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (zeige PLA2G2A Proteine) activity, an interaction that could function to terminate the PLA2 (zeige PLA2G2A Proteine)-mediated NOX2 (zeige CYBB Proteine) activation signal.
The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (zeige FDXR Proteine) oxidasesubunit (67kDa (zeige RPSA Proteine)) and the resultant metabolic oxidative stress.
Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (zeige CYBB Proteine)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (zeige SLC2A4 Proteine)-/-) mice.
This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.
This study demonstrates the involvement of ROS (zeige ROS1 Proteine) from NADPH oxidase (zeige NOX1 Proteine) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (zeige PKCd Proteine)- and ERK (zeige EPHB2 Proteine)-dependent pathways.
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2)
, neutrophil cytosolic factor 2
, neutrophil cytosol factor 2
, predicted neutrophil cytosolic factor 2
, NADPH oxidase cytosolic protein p67phox
, NADPH oxidase cytosolic protein
, 67 kDa neutrophil oxidase factor
, NADPH oxidase activator 2
, chronic granulomatous disease, autosomal 2
, neutrophil NADPH oxidase factor 2
, neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2)
, NADPH oxidase subunit (67 kD)
, NADPH oxidase subunit (67kDa)