Neutrophil Cytosolic Factor 2 Proteine (NCF2)

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. Zusätzlich bieten wir Ihnen NCF2 Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NCF2 4688 P19878
NCF2 17970 O70145
NCF2 364018 A7E3N2
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Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Baculovirus infected Insect Cells Human Unkonjugiert 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
609,52 €
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HOST_Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
624,76 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.334,92 €
Details
HOST_Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
798,81 €
Details

NCF2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , , ,
Mouse (Murine) ,
,
Rat (Rattus)

Weitere Proteine zu Neutrophil Cytosolic Factor 2 (NCF2) Interaktionspartnern

Pig (Porcine) Neutrophil Cytosolic Factor 2 (NCF2) Interaktionspartner

  1. analysis of NCF2, BCKDHB (zeige BCKDHB Proteine) and BCKDHA (zeige BCKDHA Proteine) in pig

Human Neutrophil Cytosolic Factor 2 (NCF2) Interaktionspartner

  1. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (zeige NCF4 Proteine) and p67phox at the phagosomal membrane.

  2. TLR4 (zeige TLR4 Proteine)- and TLR2-induced IRAK (zeige IRAK1 Proteine)-ERK (zeige EPHB2 Proteine) pathway cross-talks with p67phox-Nox-2 (zeige CYBB Proteine) for reactive oxygen species generation, thus regulating IL-1beta (zeige IL1B Proteine) transcription and processing in monocytic cells.

  3. Skeletal muscle protein expression of the NADPH oxidase (zeige NOX1 Proteine) subunits p22(phox (zeige CYBA Proteine)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (zeige CYBA Proteine)) and p67(phox) expression was attenuated by exercise training in obese subjects.

  4. A novel homozygous mutation in NCF2.

  5. results reveal an essential role for the Cys (zeige DNAJC5 Proteine)-Gly-Cys (zeige DNAJC5 Proteine) triad in Nox2 (zeige CYBB Proteine) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (zeige DNAJC5 Proteine)-Gly-Cys (zeige DNAJC5 Proteine). The 2 regions interact with distinct partner sites in p67(phox).

  6. This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (zeige NCF4 Proteine)/VAV1 (zeige VAV1 Proteine)/RAC1 NADPH oxidase (zeige NOX1 Proteine) complex.

  7. Data indicate that arachidonic acid induces the direct interaction of Rac (zeige AKT1 Proteine)-GTP (zeige AK3 Proteine)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (zeige NOX1 Proteine) Nox2 (zeige CYBB Proteine).

  8. Four novel mutations in the NCF1 (zeige NCF1 Proteine), NCF2, and CYBB (zeige CYBB Proteine) genees have been identified in chronic granulomatous disease patients in Morocco.

  9. Results not only establish allelic heterogeneity within NCF2 associated with SLE, but also emphasize the utility of multi-ethnic cohorts to identify predisposing variants explaining additional phenotypic variance of complex diseases like SLE.

  10. NCF2 in Asian populations shows a pattern of diversity characterized by a differentiated haplotype structure.

Mouse (Murine) Neutrophil Cytosolic Factor 2 (NCF2) Interaktionspartner

  1. Just as patients with chronic granulomatous disease who lack NADPH oxidase (zeige NOX1 Proteine) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.

  2. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (zeige PLA2G2A Proteine) activity, an interaction that could function to terminate the PLA2 (zeige PLA2G2A Proteine)-mediated NOX2 (zeige CYBB Proteine) activation signal.

  3. The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (zeige FDXR Proteine) oxidasesubunit (67kDa (zeige RPSA Proteine)) and the resultant metabolic oxidative stress.

  4. Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (zeige CYBB Proteine)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (zeige SLC2A4 Proteine)-/-) mice.

  5. This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.

  6. This study demonstrates the involvement of ROS (zeige ROS1 Proteine) from NADPH oxidase (zeige NOX1 Proteine) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (zeige PKCd Proteine)- and ERK (zeige EPHB2 Proteine)-dependent pathways.

NCF2 Protein Überblick

Protein Überblick

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit NCF2

  • neutrophil cytosolic factor 2 (NCF2)
  • neutrophil cytosolic factor 2 (ncf2)
  • neutrophil cytosolic factor 2 (p67phox)
  • neutrophil cytosol factor 2 (VDBG_06643)
  • neutrophil cytosolic factor 2 (PGTG_05816)
  • neutrophil cytosolic factor 2 (LOC100136240)
  • neutrophil cytosolic factor 2 (Ncf2)
  • MGC81877 Protein
  • Ncf-2 Protein
  • NOXA2 Protein
  • P67-PHOX Protein
  • P67PHOX Protein
  • zgc:158405 Protein

Bezeichner auf Proteinebene für NCF2

neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) , neutrophil cytosolic factor 2 , neutrophil cytosol factor 2 , predicted neutrophil cytosolic factor 2 , p67phox , p67-phox , NADPH oxidase cytosolic protein p67phox , NADPH oxidase cytosolic protein , 67 kDa neutrophil oxidase factor , NADPH oxidase activator 2 , chronic granulomatous disease, autosomal 2 , neutrophil NADPH oxidase factor 2 , neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) , NADPH oxidase subunit (67 kD) , NADPH oxidase subunit (67kDa) , NCF-2

GENE ID SPEZIES
424445 Gallus gallus
444487 Xenopus laevis
457573 Pan troglodytes
480036 Canis lupus familiaris
562473 Danio rerio
619224 Ciona intestinalis
619367 Xenopus (Silurana) tropicalis
9537124 Verticillium alfalfae VaMs.102
10531323 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008802 Oryctolagus cuniculus
100136240 Oncorhynchus mykiss
100142665 Sus scrofa
100174692 Pongo abelii
100270811 Salmo salar
4688 Homo sapiens
17970 Mus musculus
364018 Rattus norvegicus
281346 Bos taurus
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