anti-Naked Cuticle Homolog 1 (Drosophila) (NKD1) Antikörper

In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.. Zusätzlich bieten wir Ihnen Naked Cuticle Homolog 1 (Drosophila) Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
NKD1 93960 Q99MH6
NKD1 85407 Q969G9
NKD1 364952  
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Showing 10 out of 33 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-NKD1 Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Maus Kaninchen Unkonjugiert WB NKD1 Antibody (N-term) (ABIN657536) western blot analysis in mouse lung,heart,bladder tissue lysates (35 µg/lane). This demonstrates the NKD1 antibody detected the NKD1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Rind (Kuh) Kaninchen Unkonjugiert IHC (p), WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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Hund Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
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Human Kaninchen Unkonjugiert IHC, ELISA, WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
459,65 €
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Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: NKD1 Antibody [NBP2-30532] - Immunohistochemical staining of human colon shows moderate cytoplasmic, membranous and nuclear positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Immunohistochemistry-Paraffin: NKD1 Antibody [NBP1-55270] - Human Lung Alveolar cells (indicated with arrows), 4-8ug/ml. Western Blot: NKD1 Antibody [NBP1-55270] - HepG2 tissue lysate at a concentration of 1ug/ml. 100 μL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert WB Western Blot: NKD1 Antibody [NBP1-55269] - 721_B cell lysate, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert IHC, WB NKD1 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Alveolar cells (arrows) in Human Lung. Magnification is at 400X NKD1 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml. Magnification is at 400X 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
460,89 €
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NKD1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine)


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Human ,


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Rat (Rattus)


Am meisten referenzierte anti-Naked Cuticle Homolog 1 (Drosophila) Antikörper

  1. Cow (Bovine) Polyclonal NKD1 Primary Antibody für IHC, WB - ABIN2776729 : Yan, Wiesmann, Rohan, Chan, Jefferson, Guo, Sakamoto, Caothien, Fuller, Reinhard, Garcia, Randazzo, Escobedo, Fantl, Williams: Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta -catenin signaling is activated in human colon tumors. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)

Weitere Antikörper gegen Naked Cuticle Homolog 1 (Drosophila) Interaktionspartner

Mouse (Murine) Naked Cuticle Homolog 1 (Drosophila) (NKD1) Interaktionspartner

  1. deletion of the EF-hand from Nkd1 reduces the number of the elongating spermatids at haploid stage

  2. Viable mice were obtained with compound mutations in the Wnt (zeige WNT2 Antikörper)/Dvl (zeige DVL1 Antikörper) pathway antagonists nkd1 and nkd2 (zeige NKD2 Antikörper).

Human Naked Cuticle Homolog 1 (Drosophila) (NKD1) Interaktionspartner

  1. Data indicate that microRNA miR (zeige MLXIP Antikörper)-744 activated Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway by targeting multiple negative regulators of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling, including SFRP1 (zeige SFRP1 Antikörper), GSK3beta (zeige GSK3b Antikörper), TLE3 and NKD1, and that NKD1 is a major functional target of miR (zeige MLXIP Antikörper)-744.

  2. NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia (zeige BCL11A Antikörper) patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia (zeige BCL11A Antikörper).

  3. Low NKD1 expression is associated with hepatocellular carcinoma.

  4. Silencing of NKD1 significantly inhibited the proliferation and invasion of osteosarcoma cells.

  5. Suggest that NKD1 plays an important role in invasion in human breast cancer and it appears to be a potential prognostic marker for patients with breast cancer.

  6. Reduced NKD1 protein expression correlates with a poor prognosis in NSCLC

  7. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt (zeige WNT2 Antikörper)/Dvl (zeige DVL2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling

Zebrafish Naked Cuticle Homolog 1 (Drosophila) (NKD1) Interaktionspartner

  1. Nkd1 activity is specifically dependent on Wnt (zeige WNT2 Antikörper) ligand activation of the receptor. Nkd1 is recruited to the Wnt (zeige WNT2 Antikörper) signalosome with Dvl2 (zeige DVL2 Antikörper), where it becomes activated to move into the cytoplasm to interact with beta-catenin (zeige CTNNB1 Antikörper), inhibiting its nuclear accumulation.

  2. Nkd1 functions as a passive antagonist of Wnt (zeige WNT2 Antikörper) signaling, functioning only when homeostatic levels of Wnt (zeige WNT2 Antikörper) signaling have been breached or when Wnt (zeige WNT2 Antikörper) signaling becomes destabilized.

  3. Data demonstrate that Nkd1 binds to beta-catenin (zeige CTNNB1 Antikörper) and prevents its nuclear accumulation. Nkd1 function is dependent on its interaction with the cell membrane.

  4. Nkd1 knockdown in the dorsal forerunner cells causes beta-catenin (zeige CTNNB1 Antikörper) nuclear localization/transcriptional activation & changes in DFC migration, Kupffer's vesicle formation, ciliogenesis, left-right patterning, & asymmetric charon expression.

  5. data indicate that zebrafish Nkd1 and Nkd2 (zeige NKD2 Antikörper) function to limit both canonical and non-canonical Wnt (zeige WNT2 Antikörper) signaling

Naked Cuticle Homolog 1 (Drosophila) (NKD1) Antigen-Profil

Protein Überblick

In the mouse, Nkd is a Dishevelled (see DVL1\; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1\; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.

Genbezeichner und Symbole assoziert mit NKD1

  • naked cuticle homolog 1 (Drosophila) (NKD1) Antikörper
  • naked cuticle 1 homolog (Drosophila) (Nkd1) Antikörper
  • naked cuticle homolog 1 (Drosophila) (Nkd1) Antikörper
  • naked cuticle homolog 1 (Drosophila) (nkd1) Antikörper
  • 2810434J10Rik Antikörper
  • 9030215G15Rik Antikörper
  • Naked1 Antikörper
  • Nkd Antikörper

Bezeichner auf Proteinebene für NKD1

naked cuticle homolog 1 (Drosophila) , mNkd , mNkd1 , naked-1 , protein naked cuticle homolog 1 , Dvl-binding protein , naked cuticle-1 , naked cuticle 1 homolog , naked 1

GENE ID SPEZIES
487288 Canis lupus familiaris
93960 Mus musculus
415729 Gallus gallus
85407 Homo sapiens
618586 Bos taurus
364952 Rattus norvegicus
751108 Danio rerio
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