NIMA-Related Kinase 8 Proteine (NEK8)

NEK8 encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. Zusätzlich bieten wir Ihnen NEK8 Antikörper (84) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NEK8 284086 Q86SG6
NEK8 140859 Q91ZR4
Ratte NEK8 NEK8 287473  
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$322.08
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details

NEK8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu NIMA-Related Kinase 8 (NEK8) Interaktionspartnern

Mouse (Murine) NIMA-Related Kinase 8 (NEK8) Interaktionspartner

  1. NEK8 plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51 (zeige RAD51 Proteine).

  2. NEK8-depleted inner medullary collecting duct cells exhibited a defective response to fluid shear.

  3. Nek8 acts downstream of Inv (zeige INVS Proteine) function

  4. Inv (zeige INVS Proteine) acts as a molecular anchor for Nphp3 (zeige NPHP3 Proteine) and Nek8 in the proximal segment of primary cilia.

  5. cross-species analysis between zebrafish and mouse demonstrates taht NEK8 has a role in development of pronephric cysts

  6. Nek8 and Pkd1 (zeige PKD1 Proteine) genes function in a common pathway to regulate cystogenesis. Moreover, compound Pkd1 (zeige PKD1 Proteine) and Nek8 heterozygous adult mice develop a more aggressive cystic disease than animals with a mutation in either gene alone.

  7. Defects in ciliary localization of Nek8 is associated with polycystic kidney diseases

Zebrafish NIMA-Related Kinase 8 (NEK8) Interaktionspartner

  1. requirement for Nek8 in left-right patterning is conserved

  2. Nek8 acts downstream of Inv (zeige INVS Proteine) function

  3. cross-species analysis between zebrafish and mouse demonstrates taht NEK8 has a role in development of pronephric cysts

Human NIMA-Related Kinase 8 (NEK8) Interaktionspartner

  1. NEK8 (zeige NEK9 Proteine) plays a critical role in replication fork stability through its regulation of the DNA repair and replication fork protection protein RAD51 (zeige RAD51 Proteine).

  2. The mutations: c.2069_2070insC variant (p.Ter693LeufsTer86), and a c.1043C>T variant (p.Thr348Met) in RCC1 (zeige RCC1 Proteine) domain of NEK8 (zeige NEK9 Proteine) in two brothers with cardiac, renal, and hepatic anomalies

  3. our study demonstrates that NEK8 (zeige NEK9 Proteine) human mutations cause major organ developmental defects due to altered ciliogenesis and cell differentiation/proliferation through deregulation of the Hippo pathway

  4. NEK8 (zeige NEK9 Proteine) may be a new target gene of HIFs; pVHL (zeige VHL Proteine) can down-regulate NEK8 (zeige NEK9 Proteine) via HIFs to maintain the primary cilia structure in human renal cancer cells

  5. NEK8 (zeige NEK9 Proteine) is essential for organ development and that the complete loss of NEK8 (zeige NEK9 Proteine) perturbs multiple signalling pathways resulting in a severe early embryonic phenotype.

  6. Mutation in NEK8 (zeige NEK9 Proteine) is associated with renal ciliopathies

  7. ANKS6 as a new NPHP family member that assembles a distinct module of nephronophthisis-associated proteins, encompassing NEK8 (zeige NEK9 Proteine), INVS (zeige INVS Proteine) and NPHP3 (zeige NPHP3 Proteine).

  8. NPHP9 promotes signalling through the transcriptional co-activator TAZ (zeige TAZ Proteine).

  9. study finds that induction of ciliogenesis upon cell cycle exit is accompanied by both activation and proteasomal degradation of Nek8 (zeige NEK9 Proteine), and that activation is dependent upon phosphorylation within the catalytic domain

  10. Data demonstrate for the first time that Nek8 (zeige NEK9 Proteine) is a novel tumor associated gene, and shares considerable sequence homology with the Nek family of protein kinases and may be involved in G(2)/M progression.

NEK8 Protein Überblick

Protein Überblick

This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.

Genbezeichner und Symbole assoziert mit NIMA-Related Kinase 8 Proteine (NEK8)

  • NIMA related kinase 8 (NEK8)
  • NIMA-related kinase 8 (nek8)
  • NIMA-related kinase 8 S homeolog (nek8.S)
  • NIMA (never in mitosis gene a)-related expressed kinase 8 (Nek8)
  • NIMA-related kinase 8 (Nek8)
  • 4632401F23Rik Protein
  • b2b1449Clo Protein
  • jck Protein
  • MGC80499 Protein
  • nek12a Protein
  • nphp9 Protein

Bezeichner auf Proteinebene für NIMA-Related Kinase 8 Proteine (NEK8)

NIMA (never in mitosis gene a)- related kinase 8 , NIMA-family kinase NEK8 , NIMA-related kinase 12a , nephrocystin 9 , never in mitosis A-related kinase 8 , nimA-related protein kinase 8 , nima-related protein kinase 12a , serine/threonine-protein kinase Nek8 , serine/thrionine-protein kinase NEK8 , NIMA-related kinase 8 , NIMA (never in mitosis gene a)-related expressed kinase 8 , NIMA-related expressed kinase 8 , juvenile cystic kidney

GENE ID SPEZIES
284086 Homo sapiens
171094 Danio rerio
779142 Xenopus laevis
140859 Mus musculus
287473 Rattus norvegicus
417576 Gallus gallus
491171 Canis lupus familiaris
532332 Bos taurus
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