NIMA-Related Kinase 1 Proteine (NEK1)

The protein encoded by NEK1 is a serine/threonine kinase involved in cell cycle regulation. Zusätzlich bieten wir Ihnen NEK1 Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NEK1 18004 P51954
NEK1 4750 Q96PY6
Ratte NEK1 NEK1 290705  
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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Baculovirus infected Insect Cells Maus GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$322.08
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Insektenzellen Human GST tag   5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$560.00
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Insektenzellen Maus GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$310.00
Details

NEK1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human ,
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Weitere Proteine zu NIMA-Related Kinase 1 (NEK1) Interaktionspartnern

Mouse (Murine) NIMA-Related Kinase 1 (NEK1) Interaktionspartner

  1. NEK1 phosphorylates PP1gamma, leading to the dephosphorylation of WAPL, which, in turn, results in its retention on chromosome cores to promote loss of cohesion at the end of prophase I in mammals.

  2. Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation

  3. Nek1 is detectable in all murine tissues but its expression in wild type and kat2J heterozygous kidneys decrease as the kidneys mature. In the embryonic kidney, Nek1 expression is most prominent in cells that will become podocytes and proximal tubules.

  4. results demonstrate that Nek1 is important for proper checkpoint control and characterize for the first time a DNA damage response that does not directly involve one of the known upstream mediator kinases, ATM or ATR

  5. data suggest that TAZ (zeige TAZ Proteine) and Nek1 constitute a negative feedback loop linked through phosphorylation and ubiquitination and that the interaction of Nek1 and TAZ (zeige TAZ Proteine) maintain polycystin 2 (zeige PKD2 Proteine) at the level needed for proper ciliogenesis

  6. NEK1 is required for the maintenance of genome stability by acting at multiple junctures, including control of chromosome stability

  7. Nek1 may function as a kinase early in the DNA damage response pathway.

  8. Murine NIMA-related kinase, Nek1, is larger than previously reported, and that the full-length protein conserves the structural hallmarks of NIMA

  9. Nek1 links cell cycle progression and the primary cilium cycle.

  10. we propose that Nek1 plays a role in centrosome integrity, affecting both ciliogenesis and centrosome stability

Human NIMA-Related Kinase 1 (NEK1) Interaktionspartner

  1. Mutation in NEK1 gene is associated with amyotrophic lateral sclerosis.

  2. Nek1 phosphorylates Rad54 (zeige ATRX Proteine) and regulates Rad51 (zeige RAD51 Proteine) removal to orchestrate homologous recombination and replication fork stability.

  3. Compound heterozygous variants in NEK1 were identified in two brothers with Mohr syndrome. The nonsense variant c.1226G>A, p.(Trp409*), results in nonsense-associated alternative splicing. Ciliation in patient fibroblasts is drastically reduced.

  4. The skeletal phenotype of our patient was milder than those of previously reported cases with NEK1 mutations and those with axial SMD harboring C21orf2 (zeige C21orf2 Proteine) mutations. Phenotypes associated with NEK1 mutations are variable and the phenotype-genotype corelation in skeletal ciliopathies is challenging

  5. Nek1 overexpression in gliomas was correlated with the proliferation marker (Ki-67 (zeige MKI67 Proteine)), tumor grade, Karnofsky performance scale (KPS) and more importantly, patients' poor survival. Further studies showed that Nek1 expression level was also increased in multiple glioma cell lines (U251-MG, U87-MG, U118, H4 and U373).

  6. C21ORF2 (zeige C21orf2 Proteine) functions in the same pathway as NEK1 in DNA damage repair.

  7. Nek1 may facilitate S-phase progression by interacting with Ku80 (zeige XRCC5 Proteine) and regulating chromatin loading of replication factors.

  8. Nek1 may suppress cilia by phosphorylating pVHL (zeige VHL Proteine), which is critical to microtubule stabilization and ciliary stability.

  9. as an ATR (zeige ANTXR1 Proteine)-associated kinase, Nek1 enhances the stability and activity of ATR (zeige ANTXR1 Proteine)-ATRIP (zeige ATRIP Proteine) before DNA damage, priming ATR (zeige ANTXR1 Proteine)-ATRIP (zeige ATRIP Proteine) for a robust DNA damage response

  10. The present case provides evidence for a correlation of NEK1 mutation with short rib-polydactyly syndrome type II (Majewski.

NEK1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit NIMA-Related Kinase 1 Proteine (NEK1)

  • NIMA (never in mitosis gene a)-related expressed kinase 1 (Nek1)
  • NIMA related kinase 1 (NEK1)
  • NIMA-related kinase 1 (Nek1)
  • NIMA-related serine/threonine kinase 1 (NEK1)
  • ATNEK1 Protein
  • D8Ertd790e Protein
  • F20D21.32 Protein
  • F20D21_32 Protein
  • kat Protein
  • NIMA-RELATED KINASE1 Protein
  • NIMA-related serine/threonine kinase 1 Protein
  • NY-REN-55 Protein
  • SRPS2 Protein
  • SRPS2A Protein

Bezeichner auf Proteinebene für NIMA-Related Kinase 1 Proteine (NEK1)

NIMA-related kinase 1 , NY-REN-55 antigen , Nek1 serine/threonine- and tyrosine-specific protein kinase , kidney, anemia and testis , never in mitosis A-related kinase 1 , nimA-related protein kinase 1 , serine/threonine-protein kinase Nek1 , NIMA (never in mitosis gene a)-related kinase 1 , protein-serine/threonine kinase , renal carcinoma antigen NY-REN-55 , NIMA (never in mitosis gene a)-related expressed kinase 1

GENE ID SPEZIES
18004 Mus musculus
486058 Canis lupus familiaris
4750 Homo sapiens
534671 Bos taurus
290705 Rattus norvegicus
841893 Arabidopsis thaliana
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