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The protein encoded by NHLRC1 is a single subunit E3 ubiquitin ligase. Zusätzlich bieten wir Ihnen NHLRC1 Antikörper (53) und NHLRC1 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Malin promotes its own degradation via auto-ubiquitination.Malin preferentially degrades the phosphatase-inactive laforin (zeige EPM2A ELISA Kits) monomer.
laforin/malin complex is able to interact with and ubiquitinate both PKM1 and PKM2
Lafora disease proteins laforin (zeige EPM2A ELISA Kits) and malin negatively regulate the HIPK2 (zeige HIPK2 ELISA Kits)-p53 (zeige TP53 ELISA Kits) cell death pathway.
This study demonistrated that NHLRC1 mutations were detected in some case of Mild Lafora disease patients.
Without functional laforin (zeige EPM2A ELISA Kits)-malin complex assembled on polyglucosan bodies, polyglucosan is not degraded.
Malin regulates the recruitment of mRNA-decapping enzyme 1A (Dcp1a (zeige DCP1A ELISA Kits)) to processing bodies.
Malin forms a functional complex with laforin (zeige EPM2A ELISA Kits). This complex promotes the ubiquitination of proteins involved in glycogen (zeige GYS1 ELISA Kits) metabolism and misregulation of pathways involved in this process results in Lafora body formation. (Review)
This study identified that NHLRC1 gene mutations leading to Lafora disease in six Turkish families.
Our results indicate that malin regulates Wnt (zeige WNT2 ELISA Kits) signaling pathway through the degradation of dishevelled2 and suggest possible deregulation of Wnt (zeige WNT2 ELISA Kits) signaling in Lafora disease.
Mutations in the NHL repeat containing 1 (NHLRC1) gene are described in association with a more benign clinical course and later age of death in an adolescent patient.
This study also suggests a malin function independent of laforin (zeige EPM2A ELISA Kits), possibly in lysosomal biogenesis and/or lysosomal glycogen (zeige GYS1 ELISA Kits) disposal.
Results indicate that malin has no effect on whole-body glucose metabolism and insulin (zeige INS ELISA Kits) sensitivity.
Dysfunction of autophagy is a common feature of both laforin (zeige EPM2A ELISA Kits)- and malin-deficient mice.
malin functions to regulate laforin (zeige EPM2A ELISA Kits) and that malin deficiency at least in part causes LB and LD through increased laforin (zeige EPM2A ELISA Kits) binding to glycogen (zeige GYS1 ELISA Kits).
Results show that a functional laforin (zeige EPM2A ELISA Kits)-malin complex plays a critical role in disrupting Lafora bodies and relieving endoplasmic reticulum stres.
Motor coordination, activity impairment, and memory deficits progressively increase with age in Epm2b deficient mice.
Data conclude that EPM2B functions to maintain laforin (zeige EPM2A ELISA Kits) associated with soluble glycogen (zeige GYS1 ELISA Kits) and that its absence causes sequestration of laforin (zeige EPM2A ELISA Kits) to an insoluble polysaccharide fraction where it is functionally inert.
laforin (zeige EPM2A ELISA Kits) and malin play a role protecting cells from ER-stress, likely contributing to the elimination of unfolded proteins
The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as progressive myoclonic epilepsy type 2 (EPM2).
NHL repeat containing 1
, thiopurine methyltransferase
, NHL repeat-containing protein 1
, E3 ubiquitin-protein ligase NHLRC1
, NHL repeat-containing protein 1-like