NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Proteine (NAB2)

NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. Zusätzlich bieten wir Ihnen NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Antikörper (100) und NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NAB2 17937 Q61127
Ratte NAB2 NAB2 314910  
NAB2 4665 Q15742
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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NAB2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Interaktionspartnern

Mouse (Murine) NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Interaktionspartner

  1. These findings indicate a requirement for Nab2 in maintaining thymocyte number in male mice with age and in response to stress.

  2. Data suggest that histone deacetylase (zeige HDAC1 Proteine) inhibitors inhibit the induction of NGF1A-binding protein (zeige NAB1 Proteine) Nab2 by brain derived neurotrophic factor (BDNF (zeige BDNF Proteine)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (zeige ARPP21 Proteine), 32 kDa (DARPP-32 (zeige PPP1R1B Proteine)).

  3. Nab2 is a novel endogenous negative regulator of Egr-1 (zeige EGR1 Proteine)-dependent TGF-beta (zeige TGFB1 Proteine) signaling responsible for setting the intensity of fibrotic responses

  4. Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.

  5. repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4 (zeige CHD4 Proteine)) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex

  6. NAB2 enhances IL-2 (zeige IL2 Proteine) transcription by acting as a coactivator for Egr-1 (zeige EGR1 Proteine).NAB2 is recruited to the Egr-1 (zeige EGR1 Proteine) binding site of the IL-2 (zeige IL2 Proteine) promoter.

  7. We report here, that FGF23 (zeige FGF23 Proteine) induces not only Egr-1 (zeige EGR1 Proteine) but also two isoforms of NAB2, which are specific co-repressors of Egr-1 (zeige EGR1 Proteine).

Human NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Interaktionspartner

  1. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 (zeige STAT6 Proteine) fusion genes ,the molecular hallmark of solitary fibrous tumours.

  2. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 (zeige STAT6 Proteine) gene fusion as was nonmeningeal solitary fibrous tumor

  3. The detection of nuclear relocation of STAT6 (zeige STAT6 Proteine) with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 (zeige STAT6 Proteine) fusion and helps to discriminate SFTs from histological mimics.

  4. Variants of the NAB2-STAT6 (zeige STAT6 Proteine) fusion gene are found in solitary fibrous tumors of the meninges.

  5. NAB2-STAT6 (zeige STAT6 Proteine) fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.

  6. the majority of intrathoracic SFTs exhibited STAT6 (zeige STAT6 Proteine) nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.

  7. Case Report: NAB2-STAT6 (zeige STAT6 Proteine) fusion in glioblastoma.

  8. We delineate the common and rare NAB2-STAT6 (zeige STAT6 Proteine) fusion variants in solitary fibrous tumors

  9. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 (zeige STAT6 Proteine) nuclear expression and NAB2-STAT6 (zeige STAT6 Proteine) fusion similar to their soft tissue counterparts.

  10. This study validated the existence of the NAB2-STAT6 (zeige STAT6 Proteine) fusion gene in solitary fibrous tumors and examined its relation with pathological features.

NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) (NAB2) Protein Überblick

Protein Überblick

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Genbezeichner und Symbole assoziert mit NAB2

  • NGFI-A binding protein 2 (EGR1 binding protein 2) (nab2)
  • Ngfi-A binding protein 2 (Nab2)
  • NGFI-A binding protein 2 (NAB2)
  • AI451907 Protein
  • MADER Protein

Bezeichner auf Proteinebene für NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2) , EGR-1-binding protein 2 , NGFI-A binding protein 2 (EGR-1 binding protein 2) , NGFI-A-binding protein 2 , EGR1 binding protein 2 , melanoma-associated delayed early response protein

GENE ID SPEZIES
100145178 Xenopus (Silurana) tropicalis
17937 Mus musculus
314910 Rattus norvegicus
4665 Homo sapiens
504755 Bos taurus
481122 Canis lupus familiaris
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