N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) ELISA Kits

ASAH1 encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. Zusätzlich bieten wir Ihnen N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Antikörper (67) und N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
ASAH1 427 Q13510
ASAH1 11886 Q9WV54
Anti-Ratte ASAH1 ASAH1 84431 Q6P7S1
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.61 ng/mL 1.56-100 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
875,63 €
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  96 Tests Anmelden zum Anzeigen 20 bis 26 Tage
1.235,10 €
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Weitere ELISA Kits für N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Interaktionspartner

Human N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Interaktionspartner

  1. We report an atypical presentation of Farber disease with her pathology and associated genetic defect. This case expands the phenotypic spectrum of Farber disease to include novel mutations of ASAH1, which pose a diagnostic challenge.

  2. This study describes for the first time the association between ASAH1 variants and an adult SMA (zeige SMN1 ELISA Kits) phenotype with no myoclonic epilepsy nor death in early age, thus expanding the phenotypic spectrum of ASAH1-related SMA (zeige SMN1 ELISA Kits).

  3. Our findings indicate that hypomorphic mutations in ASAH1 may result in an osteoarticular phenotype with a juvenile phase resembling rheumatoid arthritis that evolves to osteolysis as the final stage in the absence of neurologic signs. This observation delineates a novel type of recessively inherited peripheral osteolysis and illustrates the long-term skeletal manifestations of acid ceramidase deficiency (Farber's disease

  4. The present report describes a 9-year-old girl with novel clinical phenotype of a patient with polyarticular arthritis followed by symptoms of SMA due to acid ceramidase deficiency. Whole exome sequencing identified compound heterozygous pathogenic mutation in the N-acylsphingosine amidohydrolase 1 gene.

  5. Data suggest up-regulation of ASAH1 activity by androgen in androgen-sensitive prostate cancer cells (not other cancer cells) is due to prolonged stability of ASAH1 by androgen-stimulated induction of USP2 (ubiquitin specific peptidase 2 (zeige USP2 ELISA Kits)) expression.

  6. Genetic or pharmacological acid ceramidase inhibition promotes cisplatin cytotoxicity in head and neck tumor cells.

  7. high ASAH1 expression is generally associated with an improved prognosis in invasive breast cancer independent of adjuvant treatment and could also be valuable as prognostic factor for pre-invasive DCIS.

  8. novel ASAH1 mutations affecting polypyrimidine tract deletion, and exon skipping and resulting in Farber lipogranulomatosis

  9. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt (zeige AKT1 ELISA Kits) signaling.

  10. Depletion of both Akt2 (zeige AKT2 ELISA Kits) and ASAH1 is much more potent than depleting each alone at inhibiting neoplastic cell viability/proliferation and invasion.

Mouse (Murine) N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Interaktionspartner

  1. cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 (zeige CCL5 ELISA Kits) induction, whereas cells deficient in sphingosine kinase-1 (zeige SPHK1 ELISA Kits) and -2 exhibited higher levels of CCL5 (zeige CCL5 ELISA Kits).

  2. biochemistry of acid ceramidase reaction with acid sphingomyelinase (zeige SMPD1 ELISA Kits)

  3. Acid and neutral sphingomyelinase (zeige SMPD2 ELISA Kits), ceramide synthase, and acid ceramidase have roles in cutaneous aging

  4. These results provide the first characterization of the Acid Ceremidase promoter from any species and demonstrate that Kruppel-like factor 6 (KLF6 (zeige KLF6 ELISA Kits)) is one transcription factor involved in the regulation of AC gene expression.

  5. acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway

N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Antigen-Profil

Beschreibung des Gens

This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit ASAH1

  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ASAH1) Antikörper
  • N-acylsphingosine amidohydrolase 1 (Asah1) Antikörper
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 (Asah1) Antikörper
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 (asah1) Antikörper
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1a (asah1a) Antikörper
  • N-acylsphingosine amidohydrolase 1 (LOC100338209) Antikörper
  • Protein ASAH-1 (asah-1) Antikörper
  • 2310081N20Rik Antikörper
  • AC Antikörper
  • ACDase Antikörper
  • Asah Antikörper
  • ASAH1 Antikörper
  • MGC82286 Antikörper
  • PHP Antikörper
  • PHP32 Antikörper
  • SMAPME Antikörper
  • zgc:101637 Antikörper

Bezeichner auf Proteinebene für ASAH1

acid CDase , acid ceramidase , acylsphingosine deacylase , putative 32 kDa heart protein , ACDase , Acylsphingosine deacylase , N-acylsphingosine amidohydrolase 1 , AC , N-acylsphingosine amidohydrolase (acid ceramidase) 1

GENE ID SPEZIES
427 Homo sapiens
11886 Mus musculus
464022 Pan troglodytes
84431 Rattus norvegicus
422727 Gallus gallus
447327 Xenopus laevis
450068 Danio rerio
482897 Canis lupus familiaris
510620 Bos taurus
703699 Macaca mulatta
100171626 Pongo abelii
100223185 Taeniopygia guttata
100338209 Oryctolagus cuniculus
173120 Caenorhabditis elegans
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