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NOX3 encodes a member of the NOX family of NADPH oxidases. Zusätzlich bieten wir Ihnen NOX3 Antikörper (58) und NOX3 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Chemerin (zeige RARRES2 ELISA Kits)-CMKLR1 (zeige CMKLR1 ELISA Kits) activates Akt (zeige AKT1 ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) and ERK (zeige EPHB2 ELISA Kits) pathways and facilitates preadipocyte proliferation, adipogenesis, and angiogenesis. Gax (zeige MEOX2 ELISA Kits) weakens the effect of chemerin (zeige RARRES2 ELISA Kits) on preadipocyte biofunctions.
Meox2 (zeige MEOX2 ELISA Kits) haploinsufficiency increases neuronal cell loss in Alzheimer's disease.
Hsp70 (zeige HSP70 ELISA Kits) activates Stat3 (zeige STAT3 ELISA Kits) and suppresses Nox3 via TLR4 (zeige TLR4 ELISA Kits)
Together, these findings reveal that Nox2 (zeige CYBB ELISA Kits) is a Zn(2+)-regulated enzyme that mediates ZnD-induced oxidative stress and kidney hypertrophy. Understanding the specific mechanisms by which ZnD contributes to kidney damage may have an important impact on the treatment of chronic kidney disease.
Nox3 mutants and heterozygotes demonstrated a greater susceptibility to noise-induced hearing loss.
Although Nox3 overexpression revealed no apparent effect, depletion of Nox3 decreased the number of spermatogonial stem cells in both cultured spermatogonia and freshly isolated testis cells.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2 (zeige MEOX2 ELISA Kits)/Tcf15 (zeige TCF15 ELISA Kits) heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
The miRNA family miR (zeige MLXIP ELISA Kits)-130/301/721 enhances induced pluripotent stem cells generation via repression of Meox2 (zeige MEOX2 ELISA Kits).
Mutations of Nox3 include retrovirus insertion, missense mutations, splice donor mutation, a splice acceptor mutation and premature translational termination.
palmitate-induced ROS (zeige ROS1 ELISA Kits) generation and that NOX3-derived ROS (zeige ROS1 ELISA Kits) may drive palmitate-induced hepatic insulin (zeige INS ELISA Kits) resistance through JNK (zeige MAPK8 ELISA Kits) and p38(MAPK (zeige MAPK14 ELISA Kits)) pathways.
In lung transplants, our study highlights a donor-recipient interaction of NOX3 and NFE2L2 (zeige NFE2L2 ELISA Kits) that increases the risk of PGD (zeige PGD ELISA Kits).
Reduced matrigel invasion was mediated by reduced ROS (zeige ROS1 ELISA Kits) levels coinciding with decreased expression of NADPH oxidase 2 (zeige CYBB ELISA Kits), 3, 4 and 5 involved in ROS (zeige ROS1 ELISA Kits) production.
Down-regulation of NOX3 using siRNA prevented TNF-alpha (zeige TNF ELISA Kits)-induced decrease of cellular glycogen (zeige GYS1 ELISA Kits).
Nox3 is regulated by NOXO1 (zeige NOXO1 ELISA Kits), p47phox, and p67phox (zeige NCF2 ELISA Kits)
Nox3 functions together with p22(phox (zeige CYBA ELISA Kits)) as an enzyme constitutively producing superoxide
Rac1 regulates both oxidases Nox1 (zeige NOX1 ELISA Kits) and Nox3 through the Nox activators
In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase (zeige NOX1 ELISA Kits), plays an integral role in insulin (zeige INS ELISA Kits)-induced p42 (zeige EPB42 ELISA Kits)/44 Mitogen-activated protein kinase (zeige MAPK1 ELISA Kits) signal transmission and VEGF-A (zeige VEGFA ELISA Kits) production.
Roles for p22phox (zeige CYBA ELISA Kits) at several distinct points in the maturation and assembly of a functionally competent Nox3 in the plasma membrane.
Potential candidate genes in these regions that have been implicated in diabetic nephropathy and/or renal damage in models of hypertension include CYBA (zeige CYBA ELISA Kits) (or P22PHOX (zeige CYBA ELISA Kits)) (16q24), NOX1 (zeige NOX1 ELISA Kits) (10q22), and NOX3 (6q25.1-q26).
This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
NADPH oxidase 3
, NADPH oxidase 3-like
, Cd200 antigen
, MRC OX-2 antigen
, OX-2 membrane glycoprotein
, cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-OX2)
, homeobox protein MOX-2
, NADPH oxidase catalytic subunit-like 3
, gp91phox homolog 3
, mitogenic oxidase 2
, predicted NADPH oxidase-3