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Binds to myosin\; probably involved in interaction with thick myofilaments in the A-band.. Zusätzlich bieten wir Ihnen Myosin Binding Protein H Antikörper (39) und Myosin Binding Protein H Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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variation in MYBPH can modulate the severity of hypertrophy in hypertrophic cardiomyopathy patients.
MyBP-H expression signals the onset of dysregulation in actin-myosin interaction; this in turn might contribute to the pathogenesis of amyotrophic lateral sclerosis.
These results suggest that MYBPH inhibits RLC and NMHC IIA, independent components of NM IIA, and negatively regulates actomyosin organization at 2 distinct steps, resulting in firm inhibition of NM IIA assembly.
MYBPH inhibited assembly competence-conferring phosphorylation of the myosin regulatory light chain (RLC) as well as activating phosphorylation of LIM (zeige PDLIM5 Proteine) domain kinase, unexpectedly through its direct physical interaction with Rho kinase (zeige ROCK1 Proteine) 1
Binds to myosin\; probably involved in interaction with thick myofilaments in the A-band.
myosin binding protein H
, myosin-binding protein H-like
, myosin-binding protein H
, norvegicus myosin binding protein H
, 86 kDa protein
, myosin binding protein-H