Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) ELISA Kits

MLL encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Antikörper (52) und Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human MLL MLL 4297 Q03164
Anti-Maus MLL MLL 214162 P55200
Anti-Ratte MLL MLL 315606  
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Weitere ELISA Kits für Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Interaktionspartner

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN ELISA Kits) and DOT1L (zeige DOT1L ELISA Kits) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L ELISA Kits) for more effective treatment of MLL-rearranged leukemia.

  2. this indicates that DOT1L (zeige DOT1L ELISA Kits) function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L (zeige DOT1L ELISA Kits) inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  3. Studies demonstrate that histone methyl-transferase MLL1 coordinates with HIF1alpha (zeige HIF1A ELISA Kits) and histone acetyltransferase p300 (zeige EP300 ELISA Kits) and regulate hypoxia-induced HOTAIR expression. The hypoxia-induced upregulation of HOTAIR expression may contribute to its roles in tumorigenesis.

  4. MLL1 and MLL2 (zeige MLL2 ELISA Kits) collaborate to regulate gene expression and leukemia maintenance not through redundancy, but through distinct pathways.

  5. MLL1, deposits H3K4me2 at CpG-dense regions that could serve as polycomb (zeige CBX2 ELISA Kits) response elements.

  6. A patient was diagnosed with Wiedemann-Steiner syndrome based on identification of a novel de novo pathogenic variant in the KMT2A gene.

  7. MLL gene rearrangement is associated with acute lymphocytic leukemia.

  8. Our data thus extend MLL1 function to H3K4 methylation and PD-L1 (zeige CD274 ELISA Kits) transcription activation in pancreatic cancer cells.

  9. KMT2A gene rearrangement is associated with acute megakaryoblastic leukemia in non-Down syndrome.

  10. The data revealed the presence of a partial tandem duplication of the MLL gene as the only detectable copy number change and 11 non-silent somatic mutations, including DNMT3A (zeige DNMT3A ELISA Kits) R882H and NRAS (zeige NRAS ELISA Kits) G13D. All somatic lesions were present both at initial MDS (zeige PAFAH1B1 ELISA Kits)/MPN (zeige PRSS27 ELISA Kits)-U diagnosis and at AML (zeige RUNX1 ELISA Kits) presentation at similar mutant allele frequencies.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Interaktionspartner

  1. These results reveal a cooperative transcriptional activation mechanism of AEP (zeige LGMN ELISA Kits) and DOT1L (zeige DOT1L ELISA Kits) and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L (zeige DOT1L ELISA Kits) for more effective treatment of MLL-rearranged leukemia.

  2. This study demonstrated that Kmt2a regulates synaptic plasticity in striatal neurons and provides an epigenetic drug target for anxiety and dopamine-mediated behaviors.

  3. Inactivation of Kmt2a in Men1 (zeige MEN1 ELISA Kits)-deficient mice accelerated pancreatic islet tumorigenesis and shortened the average life span. Increases in cell proliferation were observed in mouse pancreatic islet tumors upon inactivation of both Kmt2a and Men1 (zeige MEN1 ELISA Kits).

  4. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  5. HoxBlinc RNA Recruits Set1 (zeige SETD1A ELISA Kits)/MLL Complexes to Activate Hox (zeige MSH2 ELISA Kits) Gene Expression Patterns and Mesoderm Lineage Development.

  6. MLL1 and DOT1L (zeige DOT1L ELISA Kits) cooperate with meningioma-1 to induce acute myeloid leukemia (zeige BCL11A ELISA Kits).

  7. Set1 role in cellular reprogramming and its interactions with Dpy30,Myc,Sox2 and Ash2l reprogramming factors

  8. The present study examined the mechanism underlying the development of KMT2A (MLL)-rearranged infant leukemia in response to in utero exposure to etoposide in a mouse model.

  9. We have demonstrated that the Mll1 gene is critical to Th1 (zeige HAND1 ELISA Kits) differentiation in humans and mice

  10. MLL is the key Taspase1 substrate whose cleavage is required for MMTV-neuinduced tumor formation.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) (MLL) Antigen-Profil

Beschreibung des Gens

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit MLL

  • lysine (K)-specific methyltransferase 2A (KMT2A) Antikörper
  • lysine (K)-specific methyltransferase 2A (Kmt2a) Antikörper
  • 6430520K01 Antikörper
  • ALL-1 Antikörper
  • All1 Antikörper
  • Cxxc7 Antikörper
  • HRX Antikörper
  • HTRX1 Antikörper
  • mKIAA4050 Antikörper
  • Mll Antikörper
  • MLL/GAS7 Antikörper
  • Mll1 Antikörper
  • MLL1A Antikörper
  • TET1-MLL Antikörper
  • TRX1 Antikörper
  • WDSTS Antikörper

Bezeichner auf Proteinebene für MLL

CDK6/MLL fusion protein , CXXC-type zinc finger protein 7 , MLL-AF4 der(11) fusion protein , MLL/GAS7 fusion protein , MLL/GMPS fusion protein , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax-like protein , zinc finger protein HRX , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia 1 , trithorax Drosophila , Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)

GENE ID SPEZIES
4297 Homo sapiens
214162 Mus musculus
315606 Rattus norvegicus
Haben Sie etwas anderes gesucht?