Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteine (MLLT3)

mouse homolog regulates pattern formation during embryogenesis [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antikörper (84) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MLLT3 4300 P42568
MLLT3 70122 A2AM29
Ratte MLLT3 MLLT3 114510  
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details

MLLT3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartnern

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartner

  1. A luciferase reporter gene assay revealed that hsp70 promoter activation is enhanced by the transcriptional co-activator AF9 and splicing mediator SNRPE, but suppressed by the coiled-coil domain-containing protein CCDC127.

  2. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  3. Results show that human MLL (zeige MLL Proteine)-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (zeige BCL11A Proteine) that expresses genes related to epithelial-mesenchymal transition.

  4. Results show that MLL (zeige MLL Proteine)-AF9 reduces Id2 and increases E2-2 (zeige TCF4 Proteine) expression to drive and sustain leukemia stem cell potential in MLL (zeige MLL Proteine)-rearranged acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL (zeige MLL Proteine)-rearranged but also t(8;21) AML (zeige RUNX1 Proteine) patients.

  5. Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.

  6. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L (zeige DOT1L Proteine)-mediated H3K79 methylation in transcription control.

  7. AF9 and its homolog ENL directly interact with AF4.

  8. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (zeige KAT6B Proteine) cells harbouring the MLL (zeige MLL Proteine)-AF9 oncogene (zeige RAB1A Proteine).

  9. Interaction with CBX8 (zeige CBX8 Proteine) precludes AF9-DOT1L (zeige DOT1L Proteine) binding.

  10. We demonstrate that leukemogenic activity of MLL (zeige MLL Proteine)-AF9 requires RUVBL2 (RuvB-like 2 (zeige RUVBL2 Proteine)), an AAA (zeige APP Proteine)+ ATPase family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartner

  1. YEATS domain of AF9 directly links histone crotonylation to active transcription.

  2. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  3. Using a PDK1 (zeige PDPK1 Proteine) conditional deletion MLL (zeige MLL Proteine)-AF9 murine AML (zeige RUNX1 Proteine) model, we revealed that the deletion of PDK1 (zeige PDPK1 Proteine) prolonged the survival of AML (zeige RUNX1 Proteine) mice by inducing LSC (zeige ARHGEF1 Proteine) apoptosis

  4. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (zeige MLLT1 Proteine)/3 and AFF proteins that is critically important for MLL (zeige MLL Proteine)-mediated transformation of HPCs

  5. Af9 mediates site-selective physical and functional recruitment of Rnf2 (zeige RNF2 Proteine) to the alpha-ENaC (zeige SCNN1A Proteine) promoter to constrain basal alpha-ENaC (zeige SCNN1A Proteine) transcription in collecting duct cells.

  6. Impaired alphaENaC (zeige SCNN1A Proteine) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  7. We demonstrate that leukemogenic activity of MLL (zeige MLL Proteine)-AF9 requires RUVBL2 (RuvB-like 2 (zeige RUVBL2 Proteine)), an AAA (zeige AAAS Proteine)+ ATPase family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  8. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (zeige EDN1 Proteine) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  9. It was concluded that +78/+92 of the epithelial Na+ channel alpha (zeige SCNN1A Proteine)-subunit (zeige POLG Proteine) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (zeige POLG Proteine) transcription.

  10. PRC2 supports aberrant self-renewal in a mouse model of MLL (zeige MLL Proteine)-AF9;Nras (zeige NRAS Proteine)(G12D) acute myeloid leukemia (zeige BCL11A Proteine).

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Protein Überblick

Protein Überblick

mouse homolog regulates pattern formation during embryogenesis

Genbezeichner und Symbole assoziert mit MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3)
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3)
  • 2210011H10Rik Protein
  • 2610012I03Rik Protein
  • 3830408D16Rik Protein
  • Af-9 Protein
  • Af9 Protein
  • D4Ertd321e Protein
  • fc39c11 Protein
  • wu:fc39c11 Protein
  • YEATS3 Protein
  • zgc:110210 Protein

Bezeichner auf Proteinebene für MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPEZIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
Ausgewählte Anbieter für Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteine (MLLT3)
Haben Sie etwas anderes gesucht?