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Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) ELISA Kits

mouse homolog regulates pattern formation during embryogenesis [RGD, Feb 2006].. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antikörper (83) und Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human MLLT3 MLLT3 4300 P42568
Anti-Maus MLLT3 MLLT3 70122 A2AM29
Anti-Ratte MLLT3 MLLT3 114510  
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Weitere ELISA Kits für Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Interaktionspartner

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartner

  1. Results show that human MLL (zeige MLL ELISA Kits)-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (zeige BCL11A ELISA Kits) that expresses genes related to epithelial-mesenchymal transition.

  2. Results show that MLL (zeige MLL ELISA Kits)-AF9 reduces Id2 and increases E2-2 (zeige TCF4 ELISA Kits) expression to drive and sustain leukemia stem cell potential in MLL (zeige MLL ELISA Kits)-rearranged acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL (zeige MLL ELISA Kits)-rearranged but also t(8;21) AML (zeige RUNX1 ELISA Kits) patients.

  3. Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.

  4. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L-mediated H3K79 methylation in transcription control.

  5. AF9 and its homolog ENL directly interact with AF4.

  6. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (zeige KAT6B ELISA Kits) cells harbouring the MLL (zeige MLL ELISA Kits)-AF9 oncogene (zeige RAB1A ELISA Kits).

  7. Interaction with CBX8 precludes AF9-DOT1L binding.

  8. We demonstrate that leukemogenic activity of MLL (zeige MLL ELISA Kits)-AF9 requires RUVBL2 (RuvB-like 2 (zeige RUVBL2 ELISA Kits)), an AAA (zeige APP ELISA Kits)+ ATPase (zeige DNAH8 ELISA Kits) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  9. neonatal cells expressing MLL (zeige MLL ELISA Kits)-AF9 were enriched for gene signatures associated with poor prognosis

  10. AF9 functions as a signaling hub that regulates transcription through dynamic recruitment of cofactors in normal hematopoiesis and in acute leukemia.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartner

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. Using a PDK1 (zeige PDPK1 ELISA Kits) conditional deletion MLL (zeige MLL ELISA Kits)-AF9 murine AML (zeige RUNX1 ELISA Kits) model, we revealed that the deletion of PDK1 (zeige PDPK1 ELISA Kits) prolonged the survival of AML (zeige RUNX1 ELISA Kits) mice by inducing LSC (zeige ARHGEF1 ELISA Kits) apoptosis

  3. define a specific pairing of two amino acids that creates a salt bridge between MLLT1/3 and AFF proteins that is critically important for MLL (zeige MLL ELISA Kits)-mediated transformation of HPCs

  4. Af9 mediates site-selective physical and functional recruitment of Rnf2 (zeige RNF2 ELISA Kits) to the alpha-ENaC (zeige SCNN1A ELISA Kits) promoter to constrain basal alpha-ENaC (zeige SCNN1A ELISA Kits) transcription in collecting duct cells.

  5. Impaired alphaENaC (zeige SCNN1A ELISA Kits) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  6. We demonstrate that leukemogenic activity of MLL (zeige MLL ELISA Kits)-AF9 requires RUVBL2 (RuvB-like 2 (zeige RUVBL2 ELISA Kits)), an AAA (zeige AAAS ELISA Kits)+ ATPase (zeige DNAH8 ELISA Kits) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  7. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (zeige EDN1 ELISA Kits) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  8. It was concluded that +78/+92 of the epithelial Na+ channel alpha (zeige SCNN1A ELISA Kits)-subunit (zeige POLG ELISA Kits) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (zeige POLG ELISA Kits) transcription.

  9. PRC2 supports aberrant self-renewal in a mouse model of MLL (zeige MLL ELISA Kits)-AF9;Nras (zeige NRAS ELISA Kits)(G12D) acute myeloid leukemia (zeige BCL11A ELISA Kits).

  10. The role of polycomb (zeige CBX2 ELISA Kits) repressive complex 2 (PRC2) function in leukemia development and progression, is reported.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antigen-Profil

Beschreibung des Gens

mouse homolog regulates pattern formation during embryogenesis

Genbezeichner und Symbole assoziert mit MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) Antikörper
  • 2210011H10Rik Antikörper
  • 2610012I03Rik Antikörper
  • 3830408D16Rik Antikörper
  • Af-9 Antikörper
  • Af9 Antikörper
  • D4Ertd321e Antikörper
  • fc39c11 Antikörper
  • wu:fc39c11 Antikörper
  • YEATS3 Antikörper
  • zgc:110210 Antikörper

Bezeichner auf Proteinebene für MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPEZIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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