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anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antikörper

mouse homolog regulates pattern formation during embryogenesis. Zusätzlich bieten wir Ihnen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MLLT3 4300 P42568
MLLT3 70122 A2AM29
MLLT3 114510  
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Showing 10 out of 83 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 8 bis 10 Tage
407,00 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MLLT3 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate Host: Rabbit  Target Name: MLLT3  Sample Tissue: Hela  Antibody Dilution: 1.0 µg/mL MLLT3 is supported by BioGPS gene expression data to be expressed in HeLa 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of AF9 (MLLT3) Antibody (C-term K486) (ABIN390128) in 293 cell line lysates (35 µg/lane). MLLT3(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert WB The anti-MLLT3 Pab (ABIN390129) is used in Western blot to detect MLLT3 in mouse cerebellum tissue lysate MLLT3 Antibody (C-term) (ABIN390129) western blot analysis in 293 cell line lysates (35 µg/lane).This demonstrates the MLLT3 antibody detected the MLLT3 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 8 bis 10 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 8 bis 10 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Detection of Human AF9 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (5, 10 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-AF9 antibody ABIN151110 used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B), and used for IP at 3 mcg/mg lysate. AF9 was also immunoprecipitated using rabbit anti-AF9 antibodies ABIN151108, ABIN151109 and another AF9 Ab at 3 mcg/mg lysate. Detection: Chemiluminescence with exposure times of 30 seconds (A and B). 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
463,75 €
Details
Hund Kaninchen Unkonjugiert WB WB Suggested Anti-MLLT3 Antibody Titration: 0.2-1 ug/mlPositive Control: HepG2 cell lysate Host: Rabbit  Target Name: MLLT3  Sample Tissue: Human Fetal Brain  Antibody Dilution: 1.0 µg/mL 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB The anti-MLLT3 Pab (ABIN390130) is used in Western blot to detect MLLT3 in HL60 tissue lysate 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert ChIP, ICC, IF, IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: THP-1 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded D54 xenograft, using AF9, antibody at 1:750 dilution. 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Details

MLLT3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , ,
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, , , , ,
Mouse (Murine)


Rat (Rattus)


Am meisten referenzierte anti-Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Antikörper

  1. Human Polyclonal MLLT3 Primary Antibody für IHC (p), WB - ABIN390128 : Iida, Seto, Yamamoto, Komatsu, Tojo, Asano, Kamada, Ariyoshi, Takahashi, Ueda: MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13. in Oncogene 1993 (PubMed)
    Zeige alle 5 Referenzen für ABIN390128

  2. Human Polyclonal MLLT3 Primary Antibody für ICC, IF - ABIN151110 : Lin, Hemenway: Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. in The Journal of biological chemistry 2010 (PubMed)
    Zeige alle 3 Referenzen für ABIN151110

  3. Human Polyclonal MLLT3 Primary Antibody für EIA, WB - ABIN358674 : Nakamura, Alder, Gu, Prasad, Canaani, Kamada, Gale, Lange, Crist, Nowell: Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Zeige alle 3 Referenzen für ABIN358674

  4. Human Polyclonal MLLT3 Primary Antibody für EIA, WB - ABIN358675 : Strissel, Strick, Tomek, Roe, Rowley, Zeleznik-Le: DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. in Human molecular genetics 2000 (PubMed)
    Zeige alle 3 Referenzen für ABIN358675

  5. Human Polyclonal MLLT3 Primary Antibody für EIA, IHC (p) - ABIN358673 : Bitoun, Oliver, Davies: The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. in Human molecular genetics 2007 (PubMed)
    Zeige alle 2 Referenzen für ABIN358673

  6. Cow (Bovine) Polyclonal MLLT3 Primary Antibody für WB - ABIN2780604 : Wei, Wunderlich, Fox, Alvarez, Cigudosa, Wilhelm, Zheng, Cancelas, Gu, Jansen, Dimartino, Mulloy: Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia. in Cancer cell 2008 (PubMed)

Weitere Antikörper gegen Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 Interaktionspartner

Human Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartner

  1. Results show that human MLL (zeige MLL Antikörper)-AF9 expression in mouse long-term hematopoietic stem cells causes invasive, chemoresistant acute myeloid leukemia (zeige BCL11A Antikörper) that expresses genes related to epithelial-mesenchymal transition.

  2. Results show that MLL (zeige MLL Antikörper)-AF9 reduces Id2 and increases E2-2 (zeige TCF4 Antikörper) expression to drive and sustain leukemia stem cell potential in MLL (zeige MLL Antikörper)-rearranged acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL (zeige MLL Antikörper)-rearranged but also t(8;21) AML (zeige RUNX1 Antikörper) patients.

  3. Exploring the mechanism how AF9 recognizes and binds H3K9ac by molecular dynamics simulations and free energy calculations.

  4. Studies identified the evolutionarily conserved Af9 YEATS domain as a novel acetyllysine-binding module and established a direct link between histone acetylation and DOT1L (zeige DOT1L Antikörper)-mediated H3K79 methylation in transcription control.

  5. AF9 and its homolog ENL directly interact with AF4.

  6. Abrogation of Rac1 signaling causes DNA double-strand breaks in acute monocytic leukemia (zeige KAT6B Antikörper) cells harbouring the MLL (zeige MLL Antikörper)-AF9 oncogene (zeige RAB1A Antikörper).

  7. Interaction with CBX8 (zeige CBX8 Antikörper) precludes AF9-DOT1L (zeige DOT1L Antikörper) binding.

  8. We demonstrate that leukemogenic activity of MLL (zeige MLL Antikörper)-AF9 requires RUVBL2 (RuvB-like 2 (zeige RUVBL2 Antikörper)), an AAA (zeige APP Antikörper)+ ATPase (zeige DNAH8 Antikörper) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  9. neonatal cells expressing MLL (zeige MLL Antikörper)-AF9 were enriched for gene signatures associated with poor prognosis

  10. AF9 functions as a signaling hub that regulates transcription through dynamic recruitment of cofactors in normal hematopoiesis and in acute leukemia.

Mouse (Murine) Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Interaktionspartner

  1. Data suggest that RAS-homolog enriched in brain protein (Rheb1) promotes MLL-AF9 fusion protein initiated acute myeloid leukemia (AML) progression through target of rapamycin complex 1 (mTORC1) signaling pathway.

  2. Using a PDK1 (zeige PDPK1 Antikörper) conditional deletion MLL (zeige MLL Antikörper)-AF9 murine AML (zeige RUNX1 Antikörper) model, we revealed that the deletion of PDK1 (zeige PDPK1 Antikörper) prolonged the survival of AML (zeige RUNX1 Antikörper) mice by inducing LSC (zeige ARHGEF1 Antikörper) apoptosis

  3. define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (zeige MLLT1 Antikörper)/3 and AFF proteins that is critically important for MLL (zeige MLL Antikörper)-mediated transformation of HPCs

  4. Af9 mediates site-selective physical and functional recruitment of Rnf2 (zeige RNF2 Antikörper) to the alpha-ENaC (zeige SCNN1A Antikörper) promoter to constrain basal alpha-ENaC (zeige SCNN1A Antikörper) transcription in collecting duct cells.

  5. Impaired alphaENaC (zeige SCNN1A Antikörper) expression due to failure to inhibit Dot1a-Af9 may play an important role in the early stages of pseudohypoaldosteronism type 1 in MR(-/-) mice.

  6. We demonstrate that leukemogenic activity of MLL (zeige MLL Antikörper)-AF9 requires RUVBL2 (RuvB-like 2 (zeige RUVBL2 Antikörper)), an AAA (zeige AAAS Antikörper)+ ATPase (zeige DNAH8 Antikörper) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.

  7. Therefore, Dot1a and Af9 as aldosterone-downregulated targets are negative regulators of endothelin-1 (zeige EDN1 Antikörper) transcription in vitro and in vivo, and may be considered as new potential therapeutic targets of kidney injury in diabetes.

  8. It was concluded that +78/+92 of the epithelial Na+ channel alpha (zeige SCNN1A Antikörper)-subunit (zeige POLG Antikörper) represents the primary Af9 binding site involved in recruiting Dot1a to repress basal and aldosterone-sensitive Na+ channel alpha-subunit (zeige POLG Antikörper) transcription.

  9. PRC2 supports aberrant self-renewal in a mouse model of MLL (zeige MLL Antikörper)-AF9;Nras (zeige NRAS Antikörper)(G12D) acute myeloid leukemia (zeige BCL11A Antikörper).

  10. The role of polycomb (zeige CBX2 Antikörper) repressive complex 2 (PRC2) function in leukemia development and progression, is reported.

Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila), Translocated To, 3 (MLLT3) Antigen-Profil

Protein Überblick

mouse homolog regulates pattern formation during embryogenesis

Genbezeichner und Symbole assoziert mit MLLT3

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog (Drosophila) (mllt3) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (MLLT3) Antikörper
  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (Mllt3) Antikörper
  • 2210011H10Rik Antikörper
  • 2610012I03Rik Antikörper
  • 3830408D16Rik Antikörper
  • Af-9 Antikörper
  • Af9 Antikörper
  • D4Ertd321e Antikörper
  • fc39c11 Antikörper
  • wu:fc39c11 Antikörper
  • YEATS3 Antikörper
  • zgc:110210 Antikörper

Bezeichner auf Proteinebene für MLLT3

protein AF-9 , ALL1-fused gene from chromosome 9 protein , YEATS domain-containing protein 3 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein , myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog , myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog , myeloid/lymphoid or mixed-lineage leukemia, translocated to, 3 , myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila) , translocated to, 3

GENE ID SPEZIES
550517 Danio rerio
4300 Homo sapiens
521962 Bos taurus
70122 Mus musculus
481556 Canis lupus familiaris
114510 Rattus norvegicus
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