Mycn Proteine (MYCN)

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Zusätzlich bieten wir Ihnen MYCN Antikörper (98) und MYCN Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MYCN 4613 P04198
MYCN 18109 P03966
Ratte MYCN MYCN 298894 Q63379
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Hefe Human His tag   50 μg Anmelden zum Anzeigen 8 bis 11 Tage
$341.00
Details
Hefe Serinus canaria His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,191.83
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,234.00
Details

MYCN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Am meisten referenzierte MYCN Proteine

  1. Human MYCN Protein expressed in Wheat germ - ABIN1311728 : Smith, Womack: A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery. in The Journal of pathology 2013 (PubMed)
    Show all 3 Pubmed References

Weitere Proteine zu Mycn (MYCN) Interaktionspartnern

Human Mycn (MYCN) Interaktionspartner

  1. Results establish evidence that high MYCN amplification can be present in retinoblastoma with or without coding sequence mutations in the RB1 (zeige RB1 Proteine) gene.

  2. USP7 (zeige USP7 Proteine) deubiquitinates MYCN to enhance its stability and transcriptional activity in neuroblastoma (zeige ARHGEF16 Proteine).

  3. The study conducted metabolic profiling of pre-malignant sympathetic ganglia and tumors derived from the TH-MYCN mouse model of neuroblastoma (zeige ARHGEF16 Proteine), that overexpresses human MYCN and compared to non-malignant ganglia from wildtype littermates. These results identify enhanced glutathione biosynthesis as a selective metabolic adaptation required for initiation of MYCN-driven neuroblastoma (zeige ARHGEF16 Proteine).

  4. Many prognostic signatures for neuroblastoma (zeige ARHGEF16 Proteine) are confounded by MYCN amplification.

  5. Increasing MYCN copy number is associated with an increasingly higher rate of unfavorable clinical/biological features, with 11q aberration being an exception. Patients with MYCN gain appear to have inferior outcomes, especially in otherwise more favorable groups.

  6. miR (zeige MLXIP Proteine)-21 enhances chemo-resistance in tongue cancer cells via directly targeting CADM1 (zeige CADM1 Proteine), and an inverse correlation between miR (zeige MLXIP Proteine)-21 and CADM1 (zeige CADM1 Proteine) expression in vivo. MiR (zeige MLXIP Proteine)-21 overexpression is attributed to MYCN-mediated transcriptional regulation, which is also predictive for a worse prognosis in tongue cancer

  7. LMO1 (zeige LMO1 Proteine) is an important oncogene (zeige RAB1A Proteine) that promotes neuroblastoma (zeige ARHGEF16 Proteine) initiation, progression, and widespread metastatic dissemination.

  8. our results identify DOT1L (zeige DOT1L Proteine) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (zeige ARHGEF16 Proteine) oncogenesis. Furthermore, they characterize DOT1L (zeige DOT1L Proteine) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (zeige ARHGEF16 Proteine).

  9. CCCTC-binding factor (CTCF (zeige CTCF Proteine)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (zeige ARHGEF16 Proteine) (NB) cells.

  10. PAX3 (zeige PAX3 Proteine)-FOXO1 (zeige FOXO1 Proteine) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. the role of N-myc in mouse lens development, was examined.

  2. Using comparative genomic hybridization, authors found that NCC (zeige SLC12A3 Proteine)-derived NBL (zeige NUMBL Proteine) tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL (zeige NUMBL Proteine) including 17q gain, 2p gain and loss of 1p36.

  3. a Mycn target gene encoding the miR (zeige MLXIP Proteine) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  4. The findings reveal a PLK1-Fbw7 (zeige FBXW7 Proteine)-Myc (zeige MYC Proteine) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Proteine) antagonists, as potential effective therapeutics for MYC (zeige MYC Proteine)-overexpressing cancers.

  5. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 Proteine)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  6. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  7. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (zeige ARHGEF16 Proteine), and is a promising approach for further clinical development.

  8. demonstrate a critical link between Myc (zeige MYC Proteine)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

  9. Loss of N-myc significantly impairs the Sonic hedgehog (zeige SHH Proteine) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (zeige CCND2 Proteine).

  10. Study shows that ground-state embryonic stem cells express low Myc (zeige MYC Proteine) levels. Deletion of both c-myc (zeige MYC Proteine) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (zeige MYC Proteine)-depleted stem cells enter a state of dormancy.

MYCN Protein Überblick

Protein Überblick

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit Mycn Proteine (MYCN)

  • MYCN proto-oncogene, bHLH transcription factor (MYCN)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN)
  • v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived (Mycn)
  • MYCN proto-oncogene, bHLH transcription factor (Mycn)
  • olfactory receptor 8S1 (LOC515887)
  • MYCN proto-oncogene, bHLH transcription factor (mycn)
  • MYCN proto-oncogene, bHLH transcription factor S homeolog (mycn.S)
  • bHLHe37 Protein
  • c-nmyc Protein
  • fb57a02 Protein
  • MODED Protein
  • mycn Protein
  • mycn-a Protein
  • mycn-b Protein
  • mycna Protein
  • MYCNOT Protein
  • N-myc Protein
  • Nmuc1 Protein
  • Nmyc Protein
  • Nmyc-1 Protein
  • nmyc1 Protein
  • ODED Protein
  • wu:fb57a02 Protein
  • XN-myc Protein
  • xN-myc1 Protein
  • XNmyc Protein
  • zgc:85706 Protein

Bezeichner auf Proteinebene für Mycn Proteine (MYCN)

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , N-myc protein , neuroblastoma myc-related oncogene 1 , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc-like protein , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog , MYCN proto-oncogene, bHLH transcription factor S homeolog , v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog S homeolog , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived, a

GENE ID SPEZIES
4613 Homo sapiens
482978 Canis lupus familiaris
421948 Gallus gallus
18109 Mus musculus
298894 Rattus norvegicus
515887 Bos taurus
252851 Danio rerio
380041 Xenopus laevis
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