Mycn Proteine (MYCN)

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Zusätzlich bieten wir Ihnen MYCN Antikörper (96) und MYCN Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MYCN 4613 P04198
Ratte MYCN MYCN 298894 Q63379
MYCN 18109 P03966
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Showing 6 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Hefe Serinus canaria His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.039,84 €
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.080,00 €
Details
Hefe Human His tag   50 μg Anmelden zum Anzeigen 12 bis 16 Tage
324,76 €
Details

MYCN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Am meisten referenzierte MYCN Proteine

  1. Human MYCN Protein expressed in Wheat germ - ABIN1311728 : Smith, Womack: A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery. in The Journal of pathology 2013 (PubMed)
    Zeige alle 3 Referenzen für 1311728

Weitere Proteine zu Mycn (MYCN) Interaktionspartnern

Human Mycn (MYCN) Interaktionspartner

  1. our results identify DOT1L (zeige DOT1L Proteine) as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma (zeige ARHGEF16 Proteine) oncogenesis. Furthermore, they characterize DOT1L (zeige DOT1L Proteine) inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma (zeige ARHGEF16 Proteine).

  2. CCCTC-binding factor (CTCF (zeige CTCF Proteine)) targets the binding sites within MYCN promoter to facilitate its expression in neuroblastoma (zeige ARHGEF16 Proteine) (NB) cells.

  3. PAX3 (zeige PAX3 Proteine)-FOXO1 (zeige FOXO1 Proteine) collaborates with MYCN during early rhabdomyosarcoma (RMS) tumourigenesis to dysregulate proliferation and inhibit myogenic differentiation and cell death.

  4. The findings reveal a PLK1-Fbw7 (zeige FBXW7 Proteine)-Myc (zeige MYC Proteine) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Proteine) antagonists, as potential effective therapeutics for MYC (zeige MYC Proteine)-overexpressing cancers.

  5. Results show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  6. Rac (zeige AKT1 Proteine) activity may be an important determinant of metastatic capability in subsets of neuroblastoma (zeige ARHGEF16 Proteine) cells lacking MYCN amplification.

  7. MYCN Gene Amplification is associated with Neuroblastoma (zeige ARHGEF16 Proteine).

  8. MYCN overexpression combined with activated anaplastic lymphoma kinase (ALK) is sufficient to induce neuroblastoma (zeige ARHGEF16 Proteine) (NB) in mouse sympathoadrenal cells

  9. MYCN amplification can be heterogeneous between tumor sites, during tumor progression or following treatment, challenging the notion that MYCN copy number does not change for a particular neuroblastoma (zeige ARHGEF16 Proteine).

  10. High MycN expression is associated with low radiosensitivity in neuroblastoma (zeige ARHGEF16 Proteine).

Mouse (Murine) Mycn (MYCN) Interaktionspartner

  1. a Mycn target gene encoding the miR (zeige MLXIP Proteine) cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor.

  2. The findings reveal a PLK1-Fbw7 (zeige FBXW7 Proteine)-Myc (zeige MYC Proteine) signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 (zeige BCL2 Proteine) antagonists, as potential effective therapeutics for MYC (zeige MYC Proteine)-overexpressing cancers.

  3. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM (zeige MMRN1 Proteine)/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells.

  4. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.

  5. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma (zeige ARHGEF16 Proteine), and is a promising approach for further clinical development.

  6. demonstrate a critical link between Myc (zeige MYC Proteine)/Mycn gene activity and glycolysis in spermatogonial stem cell self-renewal

  7. Loss of N-myc significantly impairs the Sonic hedgehog (zeige SHH Proteine) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (zeige CCND2 Proteine).

  8. Study shows that ground-state embryonic stem cells express low Myc (zeige MYC Proteine) levels. Deletion of both c-myc (zeige MYC Proteine) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (zeige MYC Proteine)-depleted stem cells enter a state of dormancy.

  9. MYCN overexpression is not sufficient for these cells to form tumors in nude mice

  10. ITGA4 (zeige ITGA4 Proteine) expression enhances metastasis in MYCN low neuroblastoma (zeige ARHGEF16 Proteine).

MYCN Protein Überblick

Protein Überblick

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.

Genbezeichner und Symbole assoziert mit Mycn Proteine (MYCN)

  • olfactory receptor, family 8, subfamily S, member 1-like (LOC515887)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN)
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (Mycn)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (MYCN)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN)
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (Mycn)
  • bHLHe37 Protein
  • c-nmyc Protein
  • MODED Protein
  • MYCNOT Protein
  • N-myc Protein
  • Nmuc1 Protein
  • Nmyc Protein
  • Nmyc-1 Protein
  • Nmyc1 Protein
  • ODED Protein

Bezeichner auf Proteinebene für Mycn Proteine (MYCN)

N-myc proto-oncogene protein , class E basic helix-loop-helix protein 37 , neuroblastoma MYC oncogene , neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene , oncogene NMYC , pp65/67 , v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived , v-myc myelocytomatosis viral related oncogene, neuroblastoma derived , Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc) , Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc) , N-myc protein , neuroblastoma myc-related oncogene 1

GENE ID SPEZIES
515887 Bos taurus
4613 Homo sapiens
298894 Rattus norvegicus
421948 Gallus gallus
482978 Canis lupus familiaris
18109 Mus musculus
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