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The protein encoded by MVB12B is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. Zusätzlich bieten wir Ihnen MVB12B Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Study suggests a novel association between SNPs in FAM125B andintra-ocular pressure in the TwinsUK cohort.
The 1.3-A atomic resolution crystal structure of the MVB12B MABP domain reveals a beta (zeige SUCLA2 Antikörper)-prism fold, a hydrophobic membrane-anchoring loop, and an electropositive phosphoinositide-binding patch.
These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A (zeige FAM125A Antikörper) and the functions of ESCRT-I (zeige VPS28 Antikörper).
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ESCRT-I complex subunit MVB12B
, family with sequence similarity 125, member B