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Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. Zusätzlich bieten wir Ihnen Multimerin 1 Antikörper (57) und Multimerin 1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.
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Human Multimerin 1 Protein expressed in Wheat germ - ABIN1311094
Satoh, Hirayama, Takano, Suzuki-Inoue, Sato, Ohta, Nakagomi, Ozaki: VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets. in Thrombosis journal 2014
Our data suggest that multimerin 1 supports platelet adhesive functions and thrombus formation, which will be important to verify by generating and testing selective multimerin 1 deficient mice.
Lower levels of anti-elastin are related to CAD [ coronary artery disease ]
our studies identify MMRN1 expression as a novel biomarker that may refine acute myelogenous leukemia risk stratification.
multimerin 1 has a role in delivering and localizing factor V onto platelets prior to prothrombinase (zeige F10 Proteine) assembly
disulfide-linked complexes of multimerin and factor V in platelets could be important for modulating the function of platelet factor V and its delivery onto activated platelets
MMRN1 is a ligand for alphaIIbbeta3 and alphavbeta3
The MMRN1 binding site was located in Factor V.
Multimerin 1 binds factor V and activated factor V with high affinity and inhibits thrombin (zeige F2 Proteine) generation.
MMRN1 supported the adhesion of activated, but not resting, washed platelets over a wide range of shear rates
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.
, elastin microfibril interface located protein 4
, elastin microfibril interfacer 4
, endothelial cell multimerin
, glycoprotein Ia*