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MUC5B encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. Zusätzlich bieten wir Ihnen MUC5B Kits (48) und MUC5B Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 132 products:
Human Polyclonal MUC5B Primary Antibody für IF (p), IHC (p) - ABIN739920
Fields, Song, Rasoul, Fong, Works, Shew, Yiu, Mirsalis, DAndrea: New candidate biomarkers in the female genital tract to evaluate microbicide toxicity. in PLoS ONE 2014
Show all 2 Pubmed References
Human Polyclonal MUC5B Primary Antibody für ICC, IF - ABIN4336716
Meyerholz, Stoltz, Namati, Ramachandran, Pezzulo, Smith, Rector, Suter, Kao, McLennan, Tearney, Zabner, McCray, Welsh: Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. in American journal of respiratory and critical care medicine 2010
IL-33 (zeige IL33 Antikörper) induced MUC5AC mRNA and MUC5AC protein, and also goblet cell hyperplasia at air liquid interface culture in human nasal epithelial cells. In addition to that, IL-33 (zeige IL33 Antikörper) induced MUC5B and FOXA3 (zeige FOXA3 Antikörper), and reduces FOXJmRNA.
MUC5B has physiologic functions in the mucus gel that ensure normal mucus clearance.
Down-regulation of MUC5B profoundly alters proliferation, migration and invasion of gastrointestinal cancer cells.
Mucins and AQP5 gene expression were significantly higher in patients with OME relative to controls. A 2-fold increase in MUC5B correlated with increased hearing loss (air-bone gap: 7.45 dB [95% CI, 2.65-12.24 dB]; sound field: 6.66 dB [95% CI, 6.63-6.69 dB]), effusion viscosity (2.75 mL/mg; 95% CI, 0.89-4.62 mL/mg), middle ear epithelial thickness (3.5 mum; 95% CI, 1.96-5.13 mum), and neutrophil infiltration (odds rat...
This study identified rare and common variants in the MUC5B gene that are associated with type 2 diabetes in Han Chinese. These findings suggest that dysregulated MUC5B expression may be involved in the pathogenesis of type 2 diabetes.
a critical regulatory domain that contains the MUC5B promoter variant and has a highly conserved forkhead box protein A2 (FOXA2 (zeige FOXA2 Antikörper)) binding motif, is identified.
There is no evidence of major proteolytic processing of D-domains during the production of the mature secreted polymeric mucin (zeige SLC13A2 Antikörper) in normal and cystic fibrosis (zeige S100A8 Antikörper) primary bronchial epithelial cells.
MUC5B was significantly more often detected in middle ear effusion fluid relative to MUC5AC. MUC5B presence was statistically associated with mucoid effusions relative to serous effusions.
Results collectively indicate unique links between dual-specificity phosphatase 28 (DUSP28) and mucins MUC5B/MUC16 and their roles in pancreatic cancer.
Study provides evidence showing that MUC5B expression in cancer cells contributes to certain tumorigenic properties of breast cancer cells, such as cell growth, adhesion, clonogenic ability and drug chemo-resistance.
The decrease density of mucin-5B (Muc5b+) conjunctival goblet cell population in the dry eye syndrome (DES (zeige DES Antikörper)) model reflects the whole conjunctival goblet cell loss, indicating Muc5b is a biological marker of DES (zeige DES Antikörper) models.
Reduced levels of Muc5b in aged mice may be contribute to decreased mucociliary clearance.
Both compounds down regulated mucin (zeige SLC13A2 Antikörper) 5 subtype B, and peptidoglycan recognition protein 1 (zeige PGLYRP1 Antikörper) in vaginal tissue
Expressions of Orai1 (zeige TMEM132A Antikörper), Muc5b, IL-4 (zeige IL4 Antikörper), IL-5 (zeige IL5 Antikörper), IL-13 (zeige IL13 Antikörper) and IL-33 (zeige IL33 Antikörper) were up-regulated in the allergic state and IL-33 (zeige IL33 Antikörper) increased the levels of Muc5b, IL-4 (zeige IL4 Antikörper), IL-5 (zeige IL5 Antikörper) and IL-13 (zeige IL13 Antikörper), but did not influence proliferation of T cells.
deleting either the Muc5ac or Muc5b gene is insufficient to create an observable dry eye phenotype on the ocular surface of these mice.
mouse Muc5b (but not Muc5ac) is required for mucociliary clearance, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac is dispensable
Muc5b was detected in all mammary tumors analyzed from MMTV-ras mice
Muc5b is a target gene of transcription factors (TTF-1, GATA-6) involved in lung differentiation programs during development and carcinogenesis. TTF-1 is a strong repressor of Muc5b.
analysis of Muc5ac and Muc5b production during prenatal and postnatal murine lung development
Acidic pH drives middle ear epithelial Muc5b gene expression in vitro, which perhaps explains how laryngopharyngeal reflux can contribute to otitis media.
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases.
cervical mucin MUC5B
, high molecular weight salivary mucin MG1
, mucin 5, subtype B, tracheobronchial
, sublingual gland mucin
, ovomucin, alpha-subunit
, mucin 5B, oligomeric mucus/gel-forming
, mucin protein
, mucin 5, subtype B, tracheobronchial-like