Mitofusin 1 Proteine (MFN1)

The protein encoded by MFN1 is a mediator of mitochondrial fusion. Zusätzlich bieten wir Ihnen Mitofusin 1 Antikörper (137) und Mitofusin 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MFN1 55669 Q8IWA4
MFN1 67414 Q811U4
Ratte MFN1 MFN1 192647 Q8R4Z9
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Showing 8 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 56 bis 61 Tage
5.753,97 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
609,52 €
Details
HOST_Escherichia coli (E. coli) Maus T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
655,24 €
Details

MFN1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , , ,
Mouse (Murine) ,
, ,

Weitere Proteine zu Mitofusin 1 (MFN1) Interaktionspartnern

Cow (Bovine) Mitofusin 1 (MFN1) Interaktionspartner

  1. The results showed that high level of Mfn1 expression significantly improved the embryo development rates by increasing ATP level and Deltapsim, while reducing H(2)O(2) generation.

Human Mitofusin 1 (MFN1) Interaktionspartner

  1. Regulation of Mfn1 by MGRN1 (zeige MGRN1 Proteine) and the proteasome modulates mitochondrial fusion.

  2. SLC25A46 (zeige SLC25A46 Proteine) is a new component in mitochondrial dynamics that serves as a regulator for MFN1/2 oligomerization.

  3. MFN1-positive expression could be seen mainly in ganglion cells after 1 week of minus lens intervention, and with time extension, more and more positive cells appeared in the rod-cone cell and bipolar cell layer, and this phenomenon could not be found in the normal control eyes.

  4. crystal structures of engineered human MFN1 containing the GTPase (zeige RACGAP1 Proteine) domain and a helical domain during different stages of GTP (zeige AK3 Proteine) hydrolysis; mechanistic model for MFN1-mediated mitochondrial tethering is proposed; results shed light on the molecular basis of mitochondrial fusion and mitofusin (zeige MFN2 Proteine)-related human neuromuscular disorders

  5. These results suggest that MFN (zeige TLL1 Proteine) tethers apposing membranes, likely through nucleotide-dependent dimerization.

  6. Improper transcriptional (in)activation of mitofusin-1 and dynamin-related protein 1 (zeige DNM1L Proteine) during early in vitro embryo development is associated with a decrease in mitochondrial membrane potential and with embryo fragmentation.

  7. A fine balance of Mfn1 levels is maintained by MARCH5 (zeige MARCH5 Proteine)-mediated quality control on acetylated Mfn1.

  8. miR (zeige MLXIP Proteine)-19b targets 3'UTR sequences of Mfn1 genes inhibit the expression of Mfn1

  9. In a amyotrophic lateral sclerosis transgenic mouse model, Mfn1 is significantly increased in spinal cord.

  10. A novel role for the endoplasmic reticulum-associated Gp78 (zeige AMFR Proteine) ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy.

Mouse (Murine) Mitofusin 1 (MFN1) Interaktionspartner

  1. We found that mouse embryonic fibroblasts lacking Mfn2 (zeige MFN2 Proteine) have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 (zeige MFN2 Proteine) does not have a role in adipocyte differentiation.

  2. MFN1 deficiency leads to defects in mitochondrial activity and male infertility.

  3. Report exposes a novel role for Shh (zeige SHH Proteine) in regulating mitochondrial dynamics and rescue the metabolic profile of tumor cells through regulation of mitofusin 1 and 2.

  4. Ablating Mfn1 eliminates the cardiac-related lethality of Mff (zeige MFF Proteine) knockout mice.

  5. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: Mfn1, Mfn2 (zeige MFN2 Proteine), OPA1 (optic atrophy 1 (zeige OPA1 Proteine) protein), and Drp1 (dynamin 1-like protein (zeige DNM1L Proteine)). [REVIEW]

  6. Authors present evidence that metabolically challenged mitochondria undergo active fusion to suppress oxidative stress. In response to glucose starvation, mitofusin 1 (MFN1) becomes associated with the protein deacetylase HDAC6 (zeige HDAC6 Proteine).

  7. These findings suggest that mitochondrial impairment is a very early event in Alzheimer disease pathogenesis and abnormal expression of Mfn1 and Mfn2 (zeige MFN2 Proteine) caused by excessive intracellular Abeta (zeige APP Proteine) is the possible molecular mechanism.

  8. Data identify MFN1 as an ERK (zeige EPHB2 Proteine) target to modulate mitochondrial shape and apoptosis.

  9. A fine balance of Mfn1 levels is maintained by MARCH5 (zeige MARCH5 Proteine)-mediated quality control on acetylated Mfn1.

  10. Mitochondrial shape governs BAX (zeige BAX Proteine)-induced membrane permeabilization and apoptosis via Mfn1.

Mitofusin 1 (MFN1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.

Genbezeichner und Symbole assoziert mit Mitofusin 1 Proteine (MFN1)

  • mitofusin 1b (mfn1b)
  • mitofusin 1 (MFN1)
  • mitofusin 1 (mfn1)
  • mitofusin 1 (Mfn1)
  • 2310002F04Rik Protein
  • 6330416C07Rik Protein
  • D3Ertd265e Protein
  • Fzo1b Protein
  • hfzo1 Protein
  • hfzo2 Protein
  • HR2 Protein
  • MFN1 Protein
  • MFN2 Protein
  • mitofusin-1 Protein
  • mKIAA4032 Protein
  • zgc:66150 Protein

Bezeichner auf Proteinebene für Mitofusin 1 Proteine (MFN1)

mitofusin 1 , mitofusin-1 , mitofusin 2 , mitofusin-1-like , fzo homolog , mitochondrial transmembrane GTPase FZO-2 , mitochondrial transmembrane GTPase Fzo-1 , putative transmembrane GTPase , transmembrane GTPase MFN1 , mitochondrial transmembrane GTPase FZO1B

GENE ID SPEZIES
393620 Danio rerio
424973 Gallus gallus
460861 Pan troglodytes
488086 Canis lupus familiaris
495314 Xenopus laevis
515180 Bos taurus
548943 Xenopus (Silurana) tropicalis
100394906 Callithrix jacchus
100586660 Nomascus leucogenys
55669 Homo sapiens
67414 Mus musculus
192647 Rattus norvegicus
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