Microtubule Associated serine/threonine Kinase-Like (MASTL) ELISA Kits

MASTL encodes a microtubule-associated serine/threonine kinase. Zusätzlich bieten wir Ihnen MASTL Antikörper (80) und MASTL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
MASTL 84930 Q96GX5
MASTL 67121 Q8C0P0
Anti-Ratte MASTL MASTL 307169  
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Top MASTL ELISA Kits auf antikoerper-online.de

Showing 6 out of 6 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human
  96 Tests Anmelden zum Anzeigen 10 bis 11 Tage
543,20 €
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Hund
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
1.013,20 €
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Human
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Maus
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
788,70 €
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Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
945,85 €
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Huhn
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
1.013,20 €
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Weitere ELISA Kits für MASTL Interaktionspartner

Zebrafish Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. transient knockdown of MASTL correlates with a decrease in the expression of c-mpl and GpIIb, and reduction of circulating thrombocytes

Human Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. Using mathematical modelling, this paper confirms that deactivation of MASTL is essential for mitotic exit.

  2. these results established that precise control of MASTL is essential to couple DNA damage to mitosis through the rate of mitotic entry and APC (zeige APC ELISA Kits)/C activation.

  3. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT (zeige AKT1 ELISA Kits) via the degradation of its phosphatase, PHLPP (zeige PHLPP1 ELISA Kits), in human malignancies.

  4. Thus, Fcp1 (zeige CTDP1 ELISA Kits) coordinates Cdk1 (zeige CDK1 ELISA Kits) and Gwl inactivation to derepress PP2A (zeige PPP2R4 ELISA Kits)-B55 (zeige MINK1 ELISA Kits), generating a dephosphorylation switch that drives mitosis progression.

  5. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA (zeige AURKA ELISA Kits) network of neuroblastoma (zeige ARHGEF16 ELISA Kits).

  6. Data show that siRNA knockdown of Forkhead box M1 (FOXM1 (zeige FOXM1 ELISA Kits)) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC).

  7. Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy

  8. data demonstrate that GWL acts in a pathway with PP2A which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes.

  9. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa (zeige ENSA ELISA Kits)/ARPP19 and Cdk (zeige CDK4 ELISA Kits) substrate dephosphorylation during mitotic exit.

  10. Studies indicate that mutations in three different genes within the THC2 (zeige ANKRD26 ELISA Kits) locus have been associated with congenital thrombocytopenia, including a mutation in MASTL.

Mouse (Murine) Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A/B55 (zeige MINK1 ELISA Kits)-mediated MPS1 dephosphorylation rather than affecting Cdk1 (zeige CDK1 ELISA Kits) kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A/B55 (zeige MINK1 ELISA Kits) pathway in preventing premature SAC (zeige ADCY10 ELISA Kits) silencing

  2. Mastl is required for the timely activation of anaphase-promoting complex (zeige CDC26 ELISA Kits)/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 (zeige CDK1 ELISA Kits) activity.

  3. Data show that Mastl (Greatwall)-null cells display mitotic collapse after nuclear envelope breakdown (NEB (zeige NEB ELISA Kits)) characterized by defective chromosome condensation and prometaphase arrest.

Xenopus laevis Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. Data suggest Greatwall kinase (Gwl) associates with protein phosphatase 1 (zeige PPP1CB ELISA Kits) (PP1 (zeige PPYR1 ELISA Kits)), particularly PP1gamma subunit, which mediates dephosphorylation of Gwl Ser (zeige SIGLEC1 ELISA Kits)-883; consistent with mitotic activation of Gwl, its association with PP1 (zeige PPYR1 ELISA Kits) is disrupted in mitotic cells; subunits PPP1R3B (zeige PPP1R3B ELISA Kits) and PPP1R13L (zeige PPP1R13L ELISA Kits) associate with Gwl; thus, PPP1R3B (zeige PPP1R3B ELISA Kits) appears to act as cell cycle regulator in oocytes that functions by governing Gwl dephosphorylation.

  2. Full dephosphorylation of Gwl results in complete inactivation of Arpp19 (zeige ARPP19 ELISA Kits) and ENSA (zeige ENSA ELISA Kits), and dephosphorylation of mitotic substrates. this feed-back loop irreversibly induces mitotic exit.

  3. study provides evidence that PP1 (zeige PPYR1 ELISA Kits) targets the auto-phosphorylation site of Gwl, resulting in efficient Gwl inactivation; this step is necessary to facilitate subsequent complete dephosphorylation of Gwl by PP2A-B55 (zeige MINK1 ELISA Kits)

  4. we showed that the Gwl nuclear localization is indispensable for the biochemical function of Gwl in promoting mitotic entry.

  5. PP2A-B55delta, Greatwall and ARPP19 (zeige ARPP19 ELISA Kits) are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 (zeige CDK1 ELISA Kits) auto-regulatory loop responsible for its independence with respect to the PKA-negative control.

  6. Greatwall kinase and cyclin B-Cdk1 (zeige CDK1 ELISA Kits) are both critical constituents of M-phase-promoting factor.

  7. inhibition of PP2A-B55delta results from Ensa, that is phosphorylated in mitosis by the protein kinase Greatwall; this converts Ensa into specific inhibitor of PP2A-B55delta; this pathway represents a previously unknown element in mitosis control

  8. 3 phosphorylation sites (phosphosites) critical to Gwl activation (pT193, pT206, and pS883 in Xenopus laevis) located in evolutionarily conserved domains that differentiate Gwl from related kinases

  9. Coordinated interplays between Plx1 (zeige PLK1 ELISA Kits) and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  10. mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A by GW

MASTL Antigen-Profil

Beschreibung des Gens

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.

Genbezeichner und Symbole assoziert mit MASTL

  • microtubule associated serine/threonine kinase-like (mastl) Antikörper
  • microtubule associated serine/threonine kinase-like (MASTL) Antikörper
  • microtubule associated serine/threonine kinase-like (Mastl) Antikörper
  • 2700091H24Rik Antikörper
  • C88295 Antikörper
  • greatwall Antikörper
  • GW Antikörper
  • GWL Antikörper
  • hGWL Antikörper
  • im:7149025 Antikörper
  • MAST-L Antikörper
  • MASTL Antikörper
  • RP11-85G18.2 Antikörper
  • thc2 Antikörper
  • wu:fa02a12 Antikörper
  • zgc:100990 Antikörper

Bezeichner auf Proteinebene für MASTL

microtubule-associated serine/threonine-protein kinase-like , serine/threonine-protein kinase greatwall , microtubule associated serine/threonine kinase-like , greatwall protein kinase , Serine/threonine-protein kinase greatwall , Microtubule-associated serine/threonine-protein kinase-like

GENE ID SPEZIES
445215 Danio rerio
450367 Pan troglodytes
708134 Macaca mulatta
100441835 Pongo abelii
100514867 Sus scrofa
100541707 Meleagris gallopavo
100602092 Nomascus leucogenys
84930 Homo sapiens
67121 Mus musculus
307169 Rattus norvegicus
540206 Bos taurus
420487 Gallus gallus
607216 Canis lupus familiaris
100464443 Ailuropoda melanoleuca
414585 Xenopus laevis
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