anti-Microtubule Associated serine/threonine Kinase-Like (MASTL) Antikörper

MASTL encodes a microtubule-associated serine/threonine kinase. Zusätzlich bieten wir Ihnen MASTL Kits (6) und MASTL Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MASTL 84930 Q96GX5
MASTL 67121 Q8C0P0
MASTL 307169  
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Top anti-MASTL Antikörper auf antikoerper-online.de

Showing 10 out of 80 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MASTL AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Fetal Heart 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2 cells, using MASTL Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Maus Unkonjugiert IF, WB MASTL  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MASTL antibody detected the MASTL protein (arrow). Confocal immunofluorescent analysis of MASTL Antibody  with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: MASTL Antibody [NBP1-22987] - FFPE section of human ovarian carcinoma. Antibody used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. 100 μL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: MASTL Antibody [NBP1-83680] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: MASTL Antibody [NBP1-83680] - Staining of human lymph node shows strong cytoplasmic positivity in subsets of cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Maus Kaninchen Unkonjugiert WB Mouse Mastl Antibody (Center) (ABIN658210) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the Mastl antibody detected the Mastl protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Maus Unkonjugiert WB MASTL  western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MASTL antibody detected the MASTL protein (arrow). 0.1 mL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of MASTL Antibody (ABIN652294) in HepG2, MDA-MB231, 293, Hela cell line lysates (35 µg/lane). MASTL (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with MASTL Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details

MASTL Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , , ,
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Mouse (Murine)


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Rat (Rattus)


Am meisten referenzierte anti-MASTL Antikörper

  1. Human Polyclonal MASTL Primary Antibody für ICC, IF - ABIN4332787 : Hégarat, Vesely, Vinod, Ocasio, Peter, Gannon, Oliver, Novák, Hochegger: PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. in PLoS genetics 2014 (PubMed)

  2. Human Polyclonal MASTL Primary Antibody für IHC, IHC (p) - ABIN439669 : Della Monica, Visconti, Cervone, Serpico, Grieco: Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression. in eLife 2016 (PubMed)

Weitere Antikörper gegen MASTL Interaktionspartner

Zebrafish Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. transient knockdown of MASTL correlates with a decrease in the expression of c-mpl (zeige MPL Antikörper) and GpIIb (zeige ITGA2B Antikörper), and reduction of circulating thrombocytes

Human Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. Using mathematical modelling, this paper confirms that deactivation of MASTL is essential for mitotic exit.

  2. these results established that precise control of MASTL is essential to couple DNA damage to mitosis through the rate of mitotic entry and APC (zeige APC Antikörper)/C activation.

  3. Thus, GWL is a human oncoprotein that promotes the hyperactivation of AKT (zeige AKT1 Antikörper) via the degradation of its phosphatase, PHLPP (zeige PHLPP1 Antikörper), in human malignancies.

  4. Thus, Fcp1 (zeige CTDP1 Antikörper) coordinates Cdk1 (zeige CDK1 Antikörper) and Gwl inactivation to derepress PP2A (zeige PPP2R4 Antikörper)-B55 (zeige MINK1 Antikörper), generating a dephosphorylation switch that drives mitosis progression.

  5. Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA (zeige AURKA Antikörper) network of neuroblastoma (zeige ARHGEF16 Antikörper).

  6. Data show that siRNA knockdown of Forkhead box M1 (FOXM1 (zeige FOXM1 Antikörper)) or microtubule-associated serine/threonine kinase-like (MASTL) induces radiosensitivity in non-small cell lung cancer (NSCLC).

  7. Mastl upregulation is involved in cancer progression and tumor recurrence after initial cancer therapy

  8. data demonstrate that GWL acts in a pathway with PP2A (zeige PPP2R4 Antikörper) which is essential for prophase I exit and metaphase I microtubule assembly in mouse oocytes.

  9. Taken together our results suggest a hierarchy of phosphatases coordinating Greatwall, Ensa (zeige ENSA Antikörper)/ARPP19 and Cdk (zeige CDK4 Antikörper) substrate dephosphorylation during mitotic exit.

  10. Studies indicate that mutations in three different genes within the THC2 (zeige ANKRD26 Antikörper) locus have been associated with congenital thrombocytopenia, including a mutation in MASTL.

Mouse (Murine) Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. using in vitro dephosphorylation assays, we demonstrate that Mastl promotes persistent MPS1 phosphorylation by inhibiting PP2A (zeige PPP2R2B Antikörper)/B55 (zeige MINK1 Antikörper)-mediated MPS1 dephosphorylation rather than affecting Cdk1 (zeige CDK1 Antikörper) kinase activity. Our findings establish a key regulatory function of the Greatwall kinase/Mastl - PP2A (zeige PPP2R2B Antikörper)/B55 (zeige MINK1 Antikörper) pathway in preventing premature SAC (zeige ADCY10 Antikörper) silencing

  2. Mastl is required for the timely activation of anaphase-promoting complex (zeige CDC26 Antikörper)/cyclosome to allow meiosis I exit and for the rapid rise of Cdk1 (zeige CDK1 Antikörper) activity.

  3. Data show that Mastl (Greatwall)-null cells display mitotic collapse after nuclear envelope breakdown (NEB (zeige NEB Antikörper)) characterized by defective chromosome condensation and prometaphase arrest.

Xenopus laevis Microtubule Associated serine/threonine Kinase-Like (MASTL) Interaktionspartner

  1. Data suggest Greatwall kinase (Gwl) associates with protein phosphatase 1 (zeige PPP1CB Antikörper) (PP1 (zeige PPYR1 Antikörper)), particularly PP1gamma subunit, which mediates dephosphorylation of Gwl Ser (zeige SIGLEC1 Antikörper)-883; consistent with mitotic activation of Gwl, its association with PP1 (zeige PPYR1 Antikörper) is disrupted in mitotic cells; subunits PPP1R3B (zeige PPP1R3B Antikörper) and PPP1R13L (zeige PPP1R13L Antikörper) associate with Gwl; thus, PPP1R3B (zeige PPP1R3B Antikörper) appears to act as cell cycle regulator (zeige CDKN2A Antikörper) in oocytes that functions by governing Gwl dephosphorylation.

  2. Full dephosphorylation of Gwl results in complete inactivation of Arpp19 (zeige ARPP19 Antikörper) and ENSA (zeige ENSA Antikörper), and dephosphorylation of mitotic substrates. this feed-back loop irreversibly induces mitotic exit.

  3. study provides evidence that PP1 (zeige PPYR1 Antikörper) targets the auto-phosphorylation site of Gwl, resulting in efficient Gwl inactivation; this step is necessary to facilitate subsequent complete dephosphorylation of Gwl by PP2A (zeige PPP2R2B Antikörper)-B55 (zeige MINK1 Antikörper)

  4. we showed that the Gwl nuclear localization is indispensable for the biochemical function of Gwl in promoting mitotic entry.

  5. PP2A (zeige PPP2R2B Antikörper)-B55delta, Greatwall and ARPP19 (zeige ARPP19 Antikörper) are not only required for entry into meiotic divisions, but are also pivotal effectors within the Cdk1 (zeige CDK1 Antikörper) auto-regulatory loop responsible for its independence with respect to the PKA-negative control.

  6. Greatwall kinase and cyclin B-Cdk1 (zeige CDK1 Antikörper) are both critical constituents of M-phase-promoting factor.

  7. inhibition of PP2A (zeige PPP2R2B Antikörper)-B55delta results from Ensa (zeige ENSA Antikörper), that is phosphorylated in mitosis by the protein kinase (zeige CSNK1D Antikörper) Greatwall; this converts Ensa (zeige ENSA Antikörper) into specific inhibitor of PP2A (zeige PPP2R2B Antikörper)-B55delta; this pathway represents a previously unknown element in mitosis control

  8. 3 phosphorylation sites (phosphosites) critical to Gwl activation (pT193, pT206, and pS883 in Xenopus laevis) located in evolutionarily conserved domains that differentiate Gwl from related kinases

  9. Coordinated interplays between Plx1 (zeige PLK1 Antikörper) and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

  10. mitotic entry and maintenance is not only mediated by the activation of cyclin B-Cdc2 but also by the regulation of PP2A (zeige PPP2R2B Antikörper) by GW

MASTL Antigen-Profil

Protein Überblick

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.

Genbezeichner und Symbole assoziert mit MASTL

  • microtubule associated serine/threonine kinase-like (mastl) Antikörper
  • microtubule associated serine/threonine kinase-like (MASTL) Antikörper
  • microtubule associated serine/threonine kinase-like (Mastl) Antikörper
  • 2700091H24Rik Antikörper
  • C88295 Antikörper
  • greatwall Antikörper
  • GW Antikörper
  • GWL Antikörper
  • hGWL Antikörper
  • im:7149025 Antikörper
  • MAST-L Antikörper
  • MASTL Antikörper
  • RP11-85G18.2 Antikörper
  • thc2 Antikörper
  • wu:fa02a12 Antikörper
  • zgc:100990 Antikörper

Bezeichner auf Proteinebene für MASTL

microtubule-associated serine/threonine-protein kinase-like , serine/threonine-protein kinase greatwall , microtubule associated serine/threonine kinase-like , greatwall protein kinase , Serine/threonine-protein kinase greatwall , Microtubule-associated serine/threonine-protein kinase-like

GENE ID SPEZIES
445215 Danio rerio
450367 Pan troglodytes
708134 Macaca mulatta
100441835 Pongo abelii
100514867 Sus scrofa
100541707 Meleagris gallopavo
100602092 Nomascus leucogenys
84930 Homo sapiens
67121 Mus musculus
307169 Rattus norvegicus
540206 Bos taurus
420487 Gallus gallus
607216 Canis lupus familiaris
100464443 Ailuropoda melanoleuca
414585 Xenopus laevis
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