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Mesencephalic Astrocyte-Derived Neurotrophic Factor Proteine (MANF)

The protein encoded by MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Zusätzlich bieten wir Ihnen MANF Antikörper (89) und MANF Kits (26) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MANF 7873 P55145
MANF 74840  
MANF 315989  
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Top MANF Proteine auf antikoerper-online.de

Showing 10 out of 28 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Human Cells Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
324,76 €
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
624,76 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
202,38 €
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.243,65 €
Details

MANF Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , ,
, , , ,
Mouse (Murine) ,

Rat (Rattus)

Am meisten referenzierte MANF Proteine

  1. Mouse (Murine) MANF Protein expressed in Human Cells - ABIN2008442 : Shridhar, Rivard, Shridhar, Mullins, Bostick, Sakr, Grignon, Miller, Smith: A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. in Oncogene 1996 (PubMed)
    Zeige alle 3 Referenzen für ABIN2008442

  2. Human MANF Protein expressed in Human Cells - ABIN2004225 : Gevaert, Goethals, Martens, Van Damme, Staes, Thomas, Vandekerckhove: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. in Nature biotechnology 2003 (PubMed)
    Zeige alle 3 Referenzen für ABIN2004225

  3. Human MANF Protein expressed in Escherichia coli (E. coli) - ABIN1098235 : Petrova, Raibekas, Pevsner, Vigo, Anafi, Moore, Peaire, Shridhar, Smith, Kelly, Durocher, Commissiong: MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. in Journal of molecular neuroscience : MN 2003 (PubMed)
    Zeige alle 2 Referenzen für ABIN1098235

Weitere Proteine zu Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Interaktionspartner

  1. These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.

  2. DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.

  3. study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF (zeige CDNF Proteine) proteins and reveals the importance of the C-terminal domain for MANF activity in vivo

  4. role of MANF in multicellular organism development

  5. DmMANF is an invertebrate neurotrophic factor (zeige NTF3 Proteine) supporting dopaminergic neurons.

Zebrafish Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Interaktionspartner

  1. These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish.

Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Interaktionspartner

  1. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.

  2. the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation.

  3. MANF is a protein that interacts with RTN1-C (zeige RTN1 Proteine)

  4. We demonstrate that Armet and Creld2 (zeige CRELD2 Proteine) are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 (zeige MATN3 Proteine) is a key disease trigger in MED that could be exploited as a potential therapeutic target

  5. MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.

  6. MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.

  7. Pretreatment with adeno (zeige ADORA2A Proteine)-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.

  8. Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response.

  9. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

  10. structures of MANF and CDNF (zeige CDNF Proteine) were solved; structure explains why MANF and CDNF (zeige CDNF Proteine) are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain

Mouse (Murine) Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Interaktionspartner

  1. MANF decreased the proinflammatory cytokines of IL-1beta (zeige IL1B Proteine), TNF-alpha (zeige TNF Proteine), and IFN-gamma induced (zeige SAMHD1 Proteine) by LPS (zeige TLR4 Proteine) by regulating NF-kappaB (zeige NFKB1 Proteine) and phosphorylation of p38 (zeige CRK Proteine)-mitogen-activated protein kinases (MAPKs) pathways

  2. MANF has immune modulatory properties that are required for retinal repair in Drosophila

  3. secretion of mouse MANF and mouse CDNF (zeige CDNF Proteine) is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF (zeige CDNF Proteine) among species might influence their intracellular functions.

  4. MANF-deficient mice develop severe diabetes, progressive postnatal reduction of beta cell mass and chronic unfolded protein response activation.

  5. Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78 (zeige HSPA5 Proteine).

  6. The change in Armet expression lasted while the change of Mrpl51 (zeige MRPL51 Proteine) disappeared after birth.

  7. the solution structure of ARMET

  8. ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum

  9. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.

MANF Protein Überblick

Protein Überblick

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.

Genbezeichner und Symbole assoziert mit MANF

  • mesencephalic astrocyte-derived neurotrophic factor (MANF)
  • Mesencephalic astrocyte-derived neurotrophic factor (Manf)
  • mesencephalic astrocyte-derived neurotrophic factor (manf)
  • mesencephalic astrocyte-derived neurotrophic factor (Manf)
  • 3230402M22Rik Protein
  • AA407711 Protein
  • AA408789 Protein
  • AA673178 Protein
  • anon-EST:ParkEST188 Protein
  • Armet Protein
  • ARP Protein
  • ARP-like Protein
  • CG7013 Protein
  • D18Mgi17 Protein
  • D17914 Protein
  • Dmel\\CG7013 Protein
  • DmMANF Protein
  • im:6909481 Protein
  • MANF Protein
  • RBM15B Protein
  • zgc:153327 Protein

Bezeichner auf Proteinebene für MANF

mesencephalic astrocyte-derived neurotrophic factor , arginine-rich, mutated in early stage tumors , CG7013-PA , Manf-PA , ARP-like , arginine-rich protein , RNA binding motif protein 15B , chromosome 3p21.1 gene sequence

GENE ID SPEZIES
745542 Pan troglodytes
41983 Drosophila melanogaster
549179 Xenopus (Silurana) tropicalis
767691 Danio rerio
7873 Homo sapiens
608421 Canis lupus familiaris
74840 Mus musculus
315989 Rattus norvegicus
540432 Bos taurus
100505460 Sus scrofa
770664 Gallus gallus
100719906 Cavia porcellus
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