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The protein encoded by MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Zusätzlich bieten wir Ihnen MANF Antikörper (95) und MANF Kits (30) und viele weitere Produktgruppen zu diesem Protein an.
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the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied.
the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation.
MANF is a protein that interacts with RTN1-C (zeige RTN1 Proteine)
We demonstrate that Armet and Creld2 (zeige CRELD2 Proteine) are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 (zeige MATN3 Proteine) is a key disease trigger in MED that could be exploited as a potential therapeutic target
MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface.
MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
Pretreatment with adeno (zeige ADORA2A Proteine)-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats.
Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response.
The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types.
structures of MANF and CDNF (zeige CDNF Proteine) were solved; structure explains why MANF and CDNF (zeige CDNF Proteine) are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain
MANF decreased the proinflammatory cytokines of IL-1beta (zeige IL1B Proteine), TNF-alpha (zeige TNF Proteine), and IFN-gamma induced (zeige SAMHD1 Proteine) by LPS (zeige TLR4 Proteine) by regulating NF-kappaB (zeige NFKB1 Proteine) and phosphorylation of p38 (zeige CRK Proteine)-mitogen-activated protein kinases (MAPKs) pathways
MANF has immune modulatory properties that are required for retinal repair in Drosophila
secretion of mouse MANF and mouse CDNF (zeige CDNF Proteine) is fundamentally regulated in the same manner, the variation of four C-terminal amino acids in the MANF and CDNF (zeige CDNF Proteine) among species might influence their intracellular functions.
MANF-deficient mice develop severe diabetes, progressive postnatal reduction of beta cell mass and chronic unfolded protein response activation.
Secretion of MANF is regulated via COPII-mediated transport and that its C-terminus could be responsible for its retention in the endoplasmic reticulum through GRP78 (zeige HSPA5 Proteine).
The change in Armet expression lasted while the change of Mrpl51 (zeige MRPL51 Proteine) disappeared after birth.
the solution structure of ARMET
ARMET is the second fully characterized ERSE-II-dependent gene and likely contributes to quality control of proteins in the endoplasmic reticulum
Study employed the Drosophila genetics to screen for potential interaction partners of Drosophila Manf (DmManf) in vivo; show that DmManf plays a role in the development of Drosophila wing.
These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.
DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.
study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF (zeige CDNF Proteine) proteins and reveals the importance of the C-terminal domain for MANF activity in vivo
role of MANF in multicellular organism development
DmMANF is an invertebrate neurotrophic factor (zeige NTF3 Proteine) supporting dopaminergic neurons.
These results suggest that MANF is involved in the regulation of the development of dopaminergic system in zebrafish.
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related.
arginine-rich, mutated in early stage tumors
, arginine-rich protein
, mesencephalic astrocyte-derived neurotrophic factor
, RNA binding motif protein 15B
, chromosome 3p21.1 gene sequence
, LOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor
, mesencephalic astrocyte-derived neurotrophic factor S homeolog