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Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Zusätzlich bieten wir Ihnen MCAM Antikörper (536) und MCAM Proteine (30) und viele weitere Produktgruppen zu diesem Protein an.
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Human MCAM ELISA Kit für Sandwich ELISA - ABIN414788
Taylan, Sari, Kozaci, Yildiz, Bilge, Coker, Maltas, Gunay, Akkoc: Evaluation of various endothelial biomarkers in ankylosing spondylitis. in Clinical rheumatology 2012
Show all 4 Pubmed References
Mouse (Murine) MCAM ELISA Kit für Sandwich ELISA - ABIN425012
Thomann, Longerich, Bazhin, Mier, Schemmer, Ryschich: Selective targeting of liver cancer with the endothelial marker CD146. in Oncotarget 2014
In the context of adult zebrafish spinal cord injury, we proved that Melanoma cell adhesion molecule (MCAM) is beneficial to the recovery, possibly via mechanisms of angiogenensis and inflammation
CD146 regulates convergent extension movement during gastrulation
In addition to the physiological angiogenesis during development, gicerin morphants efficiently blocked the tumor angiogenesis in zebrafish.
CD146 protein expression has a role in vascular development in zebrafish
CD146 was expressed in all cases of Ph-positive B- cell acute lymphoblastic leukemia and in the vast majority of T-cell acute lymphoblastic leukemia
Our results suggest that MCAM may serve as a novel therapeutic target to overcome chemoresistance in SCLC.
Authors show that KDM3A (zeige KDM3A ELISA Kits) regulates MCAM expression both through a direct mechanism, involving modulation of H3K9 methylation at the MCAM promoter, and an indirect mechanism, via the Ets1 (zeige ETS1 ELISA Kits) transcription factor.
increment of CD146 expression indicates gradual change of cultured annulus fibrosus cells to express a contractile phenotype and that transforming growth factor beta1 enhances this cellular commitment
CD146 positivity in immunohistological analysis of 11 MRT patient samples was associated with poor patient outcomes. These results suggest that CD146 defines a distinct sub-population in MRT with high tumorigenic capacity and that this marker represents a promising therapeutic target.
Promoter methylation of MCAM, ERalpha and ERbeta have a potential to be utilized as biomarker for the early detection of prostate cancer (PC) as their sensitivity and specificity seem to be better than serum PSA.
MCAM promotes tamoxifen resistance by transcriptionally suppressing ERalpha (zeige ESR1 ELISA Kits) expression and activating the AKT (zeige AKT1 ELISA Kits) pathway, followed by induction of epithelial-mesenchymal transition.
High MCAM expression is associated with lung metastasis in malignant melanoma.
Results provide evidence that MUC18 promotes viral infections both in vivo and in vitro.
soluble CD146 is released from the peripheral vasculature in response to venous stretch and may reflect systemic congestion in chronic heart failure patients
Activation of the proteolytic processing of short isoform CD146, in particular by soluble CD146, constitutes a promising pathway to improve endothelial progenitors' regenerative properties for the treatment of cardiovascular diseases.
Study shows that Mcam is upregulated in cells that have a migratory phenotype upon MEIS1 (zeige MEIS1 ELISA Kits) overexpression and identi fi ed a MEIS1 (zeige MEIS1 ELISA Kits) consensus site 113 kb upstream of the Mcam tran- scriptional start site.
Different intrinsic co-factors in different K1735 sublines, which modulate the functions of MCAM/MUC18 in the cells that interact differently to the tumor microenvironment, may render sublines manifest differently in tumorigenicity and metastasis in vivo.
Microphthalmia-associated transcription factor (zeige MITF ELISA Kits) regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule
Data show that CD146 was significantly higher expressed on tumor endothelium than on the liver.
Conditional knockout of the cd146 gene in the murine endothelium or disruption of netrin-CD146 interaction by a specific anti-CD146 antibody blocks or reduces netrin-1 (zeige NTN1 ELISA Kits)-induced angiogenesis.
MCAM is expressed by encephalitogenic CD8 (zeige CD8A ELISA Kits)+ T lymphocytes in experimental autoimmune encephalomyelitis. Blocking or depleting MCAM in vivo reduces chronic neurological deficits in active, transfer, and spontaneous progressive EAE models.
Study demonstrate for the fi rst (zeige SLC22A12 ELISA Kits) time that host CD146 contributes to hematogenous melanoma cell metastasis through a novel mechanism involving the VEGF (zeige VEGFA ELISA Kits)/FAK (zeige PTK2 ELISA Kits)/Ve-cadherin (zeige CDH5 ELISA Kits) network.
Suggest endothelial CD146 as a target for specific drug delivery in hepatocellular carcinoma.
expression of FLK1 (zeige KDR ELISA Kits), CD146 and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
cell surface glycoprotein MUC18
, melanoma adhesion molecule
, cell adhesion molecule
, similar to melanoma cell adhesion molecule
, melanoma cell adhesion molecule
, cell surface glycoprotein MUC18-like
, S-endo 1 endothelial-associated antigen
, cell surface glycoprotein P1H12
, melanoma-associated antigen A32
, melanoma-associated antigen MUC18
, l-gicerin protein