anti-Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Antikörper

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MKL1 57591 Q969V6
MKL1 315151  
MKL1 223701 Q8K4J6
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Top anti-MKL1 Antikörper auf antikoerper-online.de

Showing 10 out of 80 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-MKL1 Antibody Titration: 1.25ug/mlELISA Titer: 1:1562500Positive Control: NIH/3T3 cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
288,68 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Mkl1 Antibody [NBP1-88498] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: Mkl1 Antibody [NBP1-88498] - Immunohistochemical staining of human placenta shows strong nuclear positivity in decidual cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
Details
Maus Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
583,17 €
Details
Human Kaninchen Unkonjugiert WB MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
Details
Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
Details

MKL1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-MKL1 Antikörper

  1. Human Polyclonal MKL1 Primary Antibody für ICC, IF - ABIN4334827 : Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: RhoA as a mediator of clinically relevant androgen action in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2012 (PubMed)
    Zeige alle 5 Referenzen für 4334827

  2. Cow (Bovine) Polyclonal MKL1 Primary Antibody für WB - ABIN2780121 : Sasazuki, Sawada, Sakon, Kitamura, Kishi, Okazaki, Katano, Tanaka, Watanabe, Yagita, Okumura, Nakano: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. in The Journal of biological chemistry 2002 (PubMed)

Weitere Antikörper gegen MKL1 Interaktionspartner

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Interaktionspartner

  1. MRTF-A-miR (zeige MLXIP Antikörper)-206-WDR1 (zeige WDR1 Antikörper) form feedback loop to regulate breast cancer cell migration.

  2. miR (zeige MLXIP Antikörper)-93-5p regulates myocardin-like (zeige MYOCD Antikörper) 1 and STAT3 (zeige STAT3 Antikörper) to affect epithelial-mesenchymal transition controlling breast cancer cell migration

  3. results highlight the critical role of the actin-regulated MRTF transcriptional pathway for bleb-associated invasive motility, such as during entosis.

  4. transcriptional co-activator MRTF-A and actin polymerization regulated a subset of miRNAs in vascular smooth muscle. Identification of novel miRNAs regulated by actin/MRTF-A may provide further insight into the mechanisms underlying vascular disease states, such as aortic aneurysm, as well as novel ideas regarding therapeutic strategies

  5. Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression.

  6. RBM15 (zeige RBM15 Antikörper)-MKL1 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome.

  7. The authors show MRTF family proteins bind YAP (zeige YAP1 Antikörper) via a conserved PPXY motif that interacts with the YAP (zeige YAP1 Antikörper) WW domain (zeige DRP2 Antikörper). This interaction allows MRTF to recruit NcoA3 (zeige NCOA3 Antikörper) to the TEAD-YAP (zeige YAP1 Antikörper) transcriptional complex and potentiate its transcriptional activity.

  8. The MKL1 promotes ovarian cancer cell migration and invasion by epigenetically activating MMP2 (zeige MMP2 Antikörper) transcription.

  9. Data suggest an interplay between megakaryocytic leukemia 1 (MKL1) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha (zeige TNF Antikörper)) induced proinflammatory transcription in macrophages.

  10. The results suggest that integrin-adhesion-induced MRTF-A-SRF activation and ISG15 (zeige ISG15 Antikörper) expression constitute a newly discovered signaling circuit that promotes cell migration and invasion.

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Interaktionspartner

  1. beta-catenin (zeige CTNNB1 Antikörper) controls myocardin (zeige MYOCD Antikörper)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Interaktionspartner

  1. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  2. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (zeige PPARG Antikörper) target genes and MKL1 interacts with PPARg (zeige PPARG Antikörper), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (zeige PPARG Antikörper) activity

  3. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (zeige NFkBP65 Antikörper) during the transcription process. In an Abeta (zeige APP Antikörper) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  4. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  5. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (zeige RHOA Antikörper)/MRTF-A luciferase reporter.

  6. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (zeige TGFB1 Antikörper) signaling pathway in HSCs

  7. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

  8. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  9. MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.

  10. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 (zeige ICAM1 Antikörper) and interactions between HAoECs and leukocytes

MKL1 Antigen-Profil

Protein Überblick

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Genbezeichner und Symbole assoziert mit MKL1

  • megakaryoblastic leukemia 1 protein (MKL1) Antikörper
  • megakaryoblastic leukemia 1 protein (LOC100358994) Antikörper
  • megakaryoblastic leukemia 1 protein (mkl1) Antikörper
  • megakaryoblastic leukemia (translocation) 1 (MKL1) Antikörper
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) Antikörper
  • megakaryoblastic leukemia (translocation) 1 (mkl1) Antikörper
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) Antikörper
  • AI852829 Antikörper
  • AMKL Antikörper
  • AW743281 Antikörper
  • AW821984 Antikörper
  • Bsac Antikörper
  • Mal Antikörper
  • MKL1 Antikörper
  • Mrtf-A Antikörper
  • mrtfa Antikörper

Bezeichner auf Proteinebene für MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

GENE ID SPEZIES
745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
Ausgewählte Anbieter für anti-MKL1 (MKL1) Antikörper
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