Matrix Metallopeptidase 13 (Collagenase 3) Proteine (MMP13)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen Matrix Metallopeptidase 13 (Collagenase 3) Antikörper (287) und Matrix Metallopeptidase 13 (Collagenase 3) Kits (123) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP13 17386 P33435
MMP13 171052  
MMP13 4322 P45452
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Showing 10 out of 49 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 2 bis 3 Tage
366,67 €
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
395,77 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
655,24 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
716,19 €
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HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
740,95 €
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HOST_Escherichia coli (E. coli) Kaninchen His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
786,67 €
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HOST_Insect cells (Sf9) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 6 bis 8 Tage
453,97 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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MMP13 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus) ,

Human , , , ,
, ,

Weitere Proteine zu Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartnern

Zebrafish Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (zeige MMP9 Proteine) and Mmp13.

  2. Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.

  3. JNK (zeige MAPK8 Proteine)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo

Xenopus laevis Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. XCL3 and XCL4 can be differentially induced by prolactin (zeige PRL Proteine) and thyroid hormone (zeige PTH Proteine)(3)

Mouse (Murine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (zeige DDR2 Proteine)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (zeige DDR2 Proteine) and matrix metalloproteinase 13.

  2. Postnatal chondrocyte-specific deletion of Hdac3 (zeige HDAC3 Proteine) with an inducible Col2a1 (zeige COL2A1 Proteine)-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.

  3. Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH Proteine), and Osterix (zeige SP7 Proteine) through distal enhancers.

  4. Our study contributes to the understanding of the role of HIF1alpha (zeige HIF1A Proteine) in OA and highlights the HIF1alpha (zeige HIF1A Proteine)-beta-catenin (zeige CTNNB1 Proteine) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

  5. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (zeige MMP1 Proteine)/protease-activated receptor-1 (zeige F2R Proteine) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  6. IL-1Ra (zeige IL1RN Proteine) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (zeige IL1A Proteine) signaling cascade.

  7. We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.

  8. B-16 melanoma cells with up-regulated MMP-13 expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 expression also decreased invading cell numbers.

  9. MMP-12 (zeige MMP12 Proteine) and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.

  10. Data indicate that tamoxifen decreased collage type II COL2A1 (zeige COL2A1 Proteine) by activating matrix metallopeptidases MMP-2 (zeige MMP2 Proteine)/13 expression.

Human Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. High MMP13 expression is associated with intervertebral disc degeneration.

  2. data demonstrate that MMP-13 is critical for the development of osteolytic lesions in Multiple myeloma and that targeting the MMP-13 protein - rather than its catalytic activity - constitutes a potential approach to mitigating bone disease in affected patients.

  3. Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5 (zeige ADAMTS5 Proteine), MMP13, and decreased COL2A1 (zeige COL2A1 Proteine) expression.

  4. Matrix metalloprotease (zeige ADAM8 Proteine) (MMP) regulation was the top pathway involved in gingival aging. MMP3 (zeige MMP3 Proteine), MMP9 (zeige MMP9 Proteine), MMP12 (zeige MMP12 Proteine), and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (zeige IL1B Proteine)) expression.

  5. these findings support roles for both cFOS (indirect) and ATF3 (zeige ATF3 Proteine) (direct) in effecting MMP13 transcription in human chondrocytes.

  6. Oxytocin prevents cartilage matrix destruction via regulating MMP1 (zeige MMP1 Proteine) and MMP13.

  7. These studies have uncovered a new, ATP6V1H (zeige ATP6V1H Proteine)-mediated pathway that regulates bone formation, and defines a new mechanism of disease that leads to bone loss. We propose that MMP9 (zeige MMP9 Proteine)/MMP13 could be therapeutic targets for patients with this rare genetic disease.

  8. To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 (zeige MMP12 Proteine) and MMP-13 expression, which is further controlled by NF-kappaB (zeige NFKB1 Proteine) signaling.

  9. In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13, ADAMTS-5 (zeige ADAMTS5 Proteine), and HDAC-4 (zeige HDAC4 Proteine), and modulates the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathway activation.

  10. These results suggested that HIF-2alpha (zeige EPAS1 Proteine) may cause meniscal matrix degradation by transactivation of MMP-13

Horse (Equine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.

Cow (Bovine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. p38 (zeige MAPK14 Proteine) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  2. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  3. MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (zeige FMOD Proteine) fragments

  4. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (zeige MMP1 Proteine) and MMP-13 (follicular apex (zeige APEX1 Proteine) vs. base) for the preovulatory collagenolysis required for follicle rupture

  5. involvement of p38 MAP kinase (zeige MAPK14 Proteine) in the hyaluronan oligosaccharide induction of MMP-13

  6. MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (zeige COL2A1 Proteine)

  7. At high but naturally occurring concentrations the collagen peptide CB12-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (zeige COL2A1 Proteine) by collagenase in the mid zone and also in the superficial zone.

Rabbit Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. These results suggest that PEP-1-SIRT2 (zeige SIRT2 Proteine) promotes matrix metalloproteinases-induced dedifferentiation via ERK (zeige MAPK1 Proteine) signaling in articular chondrocytes.

  2. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (zeige MMP3 Proteine) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.

  3. Leptin (zeige LEP Proteine) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (zeige TNF Proteine) in rabbit articular chondrocytes in vitro.

Pig (Porcine) Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Interaktionspartner

  1. TNF-alpha (zeige TNF Proteine) induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.

Matrix Metallopeptidase 13 (Collagenase 3) (MMP13) Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Genbezeichner und Symbole assoziert mit MMP13

  • matrix metalloproteinase 13a (mmp13a)
  • matrix metalloproteinase 13 (MGC68994)
  • matrix metallopeptidase 13 (collagenase 3) (MMP13)
  • matrix metallopeptidase 13 (collagenase 3) (mmp13)
  • matrix metalloproteinase 13 (LOC100136348)
  • matrix metalloproteinase 13 (mmp13)
  • collagenase 3 (MMP-13)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metalloproteinase 13 precursor (MMP-13)
  • cb1034 Protein
  • Clg Protein
  • CLG3 Protein
  • gene A Protein
  • MANDP1 Protein
  • MGC108008 Protein
  • MMP-13 Protein
  • Mmp1 Protein
  • MMP13 Protein
  • xcl3 Protein
  • xCol Protein

Bezeichner auf Proteinebene für MMP13

matrix metalloproteinase 13 , MMPLg , MMPLh , matrix metallopeptidase 13 (collagenase 3) , collagenase 3 , gene A , gene 11 , collagenase-3 , collagenase 3-like , Collagenase-3 , collagenase-1 , interstitial collagenase , matrix metalloproteinase-13 , MMP-13 , UMRCASE , matrix metalloproteinase 13 (collagenase 3)

GENE ID SPEZIES
387293 Danio rerio
379552 Xenopus laevis
451513 Pan troglodytes
493679 Felis catus
613098 Xenopus (Silurana) tropicalis
703980 Macaca mulatta
772008 Gallus gallus
100012553 Monodelphis domestica
100136348 Salmo salar
100396943 Callithrix jacchus
100462632 Pongo abelii
100526826 Ictalurus punctatus
100552256 Anolis carolinensis
100584961 Nomascus leucogenys
397823 Xenopus laevis
17386 Mus musculus
171052 Rattus norvegicus
4322 Homo sapiens
100009711 Equus caballus
281914 Bos taurus
100008685 Oryctolagus cuniculus
398056 Xenopus laevis
395683 Gallus gallus
403763 Canis lupus familiaris
443113 Ovis aries
397346 Sus scrofa
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