Matrix Metallopeptidase 1 (Interstitial Collagenase) Proteine (MMP1)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP1 Antikörper (330) und MMP1 Kits (129) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP1 4312 P03956
MMP1 17386 P33435
MMP1 300339  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
HEK-293 Cells Human Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
HEK-293 Cells Human His tag   0.05 mg Anmelden zum Anzeigen 2 bis 3 Tage
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 12 bis 15 Tage
HEK-293 Cells Human His tag Human MMP-1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Maus His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 11 Days

MMP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Am meisten referenzierte MMP1 Proteine

  1. Human MMP1 Protein expressed in Human Cells - ABIN2003013 : Desrochers, Jeffrey, Weiss: Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. in The Journal of clinical investigation 1991 (PubMed)
    Show all 5 Pubmed References

Weitere Proteine zu Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartnern

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD (zeige CHDH Proteine) before and after myocardial revascularization.

  2. Results show that the expression level of MMP1 and TIMP1 (zeige TIMP1 Proteine) is under the regulation of HAS2 (zeige HAS2 Proteine) leading to migration, invasion and EMT (zeige ITK Proteine) of oral cancer cells.

  3. DDC (zeige DDC Proteine) up-regulated MMP-1 in LX-2 cells through the Akt (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine)/miR (zeige MLXIP Proteine)-222/ETS-1 (zeige ETS1 Proteine) pathways.

  4. results suggest that MMP1-1607 1G/2G, MMP3 (zeige MMP3 Proteine)-1171 5A/6A and MMP9 (zeige MMP9 Proteine)-1562 C/T gene polymorphisms have synergistic effect on breast cancer. The interactions of MMPs clinical risk factors such as lymph node involvement has shown a strong correlation and might influence the 5-years survival rate, suggesting their potential role in the breast carcinogenesis

  5. The MMP-1 -1607 (2G/1G) and -519 (A/G) polymorphisms may contribute to the onset of osteomyelitis. The 2G/2G genotype carriers had 1.605 times risk of developing osteomyelitis. In addition, frequency of -519GG genotype was obviously higher in case group than that in control group, and GG genotype related to an increased risk of osteomyelitis. Whereas, the -519G allele may be a susceptible factor for osteomyelitis.

  6. No differences in the distribution of the MMP-1 variants were found among Tunisian chronic obstructive pulmonary disease patients and healthy controls. Additionally, no significant association was retrieved between clinicopathologic parameters of chronic obstructive pulmonary disease, MMP-1 levels and this polymorphism.

  7. In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 is regulated by factors other than FLI1 (zeige FLI1 Proteine), and the influence of IL-6 (zeige IL6 Proteine) on MMP1 was independent of its effect on FLI1 (zeige FLI1 Proteine).

  8. MMP1 was produced in the tumor compartment of prostate cancer bone metastases, highlighting its accessibility to KLK4 (zeige KLK4 Proteine) at this site

  9. EREG (zeige EREG Proteine) and MMP-1 were found to be elevated in nasal polyp and uncinate tissues in patients with Chronic rhinosinusitis with nasal polyps.

  10. IL-21 (zeige IL17C Proteine) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 and MMP-3 (zeige MMP3 Proteine).

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. the identification of MMP1 and MMP10 (zeige MMP10 Proteine) genes in swine is reported.

  2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

  3. Results indicate that leukemia inhibitory factor (LIF (zeige LIF Proteine)) and Oncostatin M (zeige OSM Proteine) increase the expression of MMP-1, MMP-3 (zeige MMP3 Proteine), and TIMP-1 (zeige TIMP1 Proteine) several fold, and that their expression is reduced to basal levels in the presence of the LIF (zeige LIF Proteine) antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.

  2. Data indicate that matrix metalloproteinases mmp1 and mmp2 (zeige MMP2 Proteine) mutants have distinct heart phenotypes.

  3. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  4. A primary function of Mmp1, under the control of the JNK (zeige MAPK8 Proteine) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

  5. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (zeige GUSB Proteine) homeostasis

  6. Study identified three genes, regeneration (rgn (zeige RGN Proteine)), augmenter of liver regeneration (alr (zeige GFER Proteine)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. the phenotype seen in the Hdac4 (zeige HDAC5 Proteine)(-/-) mice is partially derived from elevation in MMP-13 (zeige MMP13 Proteine) and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

  2. MEF2C (zeige MEF2C Proteine) is necessary for Mmp13 (zeige MMP13 Proteine) gene expression at the transcriptional level and participates in PTH (zeige PTH Proteine)-stimulated Mmp13 (zeige MMP13 Proteine) gene expression by increased binding to c-FOS at the AP-1 (zeige JUN Proteine) site in the Mmp13 (zeige MMP13 Proteine) promoter.

  3. data reveal a novel involvement of MMP-13 (zeige MMP13 Proteine) in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (zeige CCL1 Proteine) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (zeige CD8A Proteine)(+) T-cell response in vitro; MMP-13 (zeige MMP13 Proteine) might be a promising target for therapeutic intervention in inflammatory diseases

  4. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (zeige DDR2 Proteine)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (zeige DDR2 Proteine) and matrix metalloproteinase 13 (zeige MMP13 Proteine).

  5. Postnatal chondrocyte-specific deletion of Hdac3 (zeige HDAC3 Proteine) with an inducible Col2a1 (zeige COL2A1 Proteine)-Cre caused premature production of pErk1/2 and Mmp13 (zeige MMP13 Proteine) in the growth plate.

  6. Mmp13 (zeige MMP13 Proteine) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH Proteine), and Osterix (zeige SP7 Proteine) through distal enhancers.

  7. Our study contributes to the understanding of the role of HIF1alpha (zeige HIF1A Proteine) in OA and highlights the HIF1alpha (zeige HIF1A Proteine)-beta-catenin (zeige CTNNB1 Proteine) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.

  8. Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 (zeige F2R Proteine) axis may play a role in neurogenesis following physiological and/or pathological stimuli.

  9. IL-1Ra (zeige IL1RN Proteine) is associated with MMP-13 (zeige MMP13 Proteine) expression and has a novel function in such regulation without interference of the IL-1 (zeige IL1A Proteine) signaling cascade.

  10. We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 (zeige MMP13 Proteine) expression and activity.

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA (zeige RBM9 Proteine), leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

  2. The expression patterns of MMP1, MMP2 (zeige MMP2 Proteine), and MMP8 (zeige MMP8 Proteine) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (zeige MMP2 Proteine), and MMP8 (zeige MMP8 Proteine) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (zeige MMP2 Proteine), and MMP8 (zeige MMP8 Proteine) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  3. Data suggest that luteolytic factors (such as interferon gamma (zeige IFNG Proteine), tumor necrosis factor alpha (zeige TNF Proteine), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  4. The results showed that a decrease in MMP-1 and MMP-2 (zeige MMP2 Proteine) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

  6. MMP-1 promotes VEGFR2 (zeige KDR Proteine) expression and proliferation of endothelial cells through stimulation of PAR-1 (zeige F2R Proteine) and activation of NF-kappaB (zeige NFKB1 Proteine)

  7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  8. the differential expression and localization of membrane-type 1 matrix metalloproteinase (zeige MMP14 Proteine) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (zeige MMP2 Proteine)

  9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (zeige MMP13 Proteine) (follicular apex (zeige APEX1 Proteine) vs. base) for the preovulatory collagenolysis required for follicle rupture

  10. identification of MT1-MMP (zeige MMP14 Proteine) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. These results suggest that PEP-1-SIRT2 (zeige SIRT2 Proteine) promotes matrix metalloproteinases-induced dedifferentiation via ERK (zeige MAPK1 Proteine) signaling in articular chondrocytes. .

  2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (zeige TIMP3 Proteine) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. ANXA2 (zeige ANXA2 Proteine) and MMP1 might participate in remodeling during wound healing in the horse.

  2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

  3. These results suggest that MMP-1 and IL-8 (zeige IL8 Proteine) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

MMP1 Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit MMP1

  • matrix metallopeptidase 1 (MMP1)
  • Matrix metalloproteinase 1 (Mmp1)
  • matrix metalloproteinase 1 (RB11133)
  • matrix metalloproteinase 1 (Mmp1)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
  • matrix metallopeptidase 1 S homeolog (mmp1.S)
  • interstitial collagenase (MMP-1)
  • interstitial collagenase (LOC100727966)
  • matrix metallopeptidase 1 (Mmp1)
  • CG4859 Protein
  • Clg Protein
  • Clgn Protein
  • col4 Protein
  • dm1-MMP Protein
  • Dmel\\CG4859 Protein
  • dmmp1 Protein
  • l(2)k04809 Protein
  • MMP-1 Protein
  • MMP-13 Protein
  • Mmp1 Protein
  • Mmp 1 Protein
  • Mmp1a Protein
  • mmp18 Protein

Bezeichner auf Proteinebene für MMP1

fibroblast collagenase , interstitial collagenase , matrix metalloprotease 1 , matrix metalloproteinase 1 , MMP-1 , matrix metalloproteinase 1 (type I collagenase) , matrix metalloproteinase-1 , CG4859-PC , CG4859-PD , CG4859-PE , CG4859-PF , CG4859-PG , CG4859-PH , CG4859-PI , CG4859-PJ , CG4859-PK , CG4859-PL , Mmp1-PC , Mmp1-PD , Mmp1-PE , Mmp1-PF , Mmp1-PG , Mmp1-PH , Mmp1-PI , Mmp1-PJ , Mmp1-PK , Mmp1-PL , Collagenase-3 , collagenase 3 , collagenase-1 , matrix metalloproteinase 13 , matrix metalloproteinase-13 , MMP-18 , collagenase-4 , matrix metalloproteinase-18 , xCol4 , matrix metallopeptidase 1a , matrix metalloproteinase 1a (interstitial collagenase) , myocardial collagenase

4312 Homo sapiens
397320 Sus scrofa
37949 Drosophila melanogaster
1790862 Rhodopirellula baltica SH 1
100144547 Bombyx mori
17386 Mus musculus
281308 Bos taurus
100009110 Oryctolagus cuniculus
489428 Canis lupus familiaris
100033896 Equus caballus
495287 Xenopus laevis
443463 Ovis aries
101120355 Ovis aries
100727966 Cavia porcellus
300339 Rattus norvegicus
Ausgewählte Anbieter für MMP1 Proteine (MMP1)
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