Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) ELISA Kits

MAN2B1 encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Zusätzlich bieten wir Ihnen Mannosidase, Alpha, Class 2B, Member 1 Antikörper (11) und Mannosidase, Alpha, Class 2B, Member 1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Maus MAN2B1 MAN2B1 17159 O09159
Anti-Ratte MAN2B1 MAN2B1 361378  
MAN2B1 4125 O00754
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 3.9 pg/mL 15.6-1000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
772,39 €
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Weitere ELISA Kits für Mannosidase, Alpha, Class 2B, Member 1 Interaktionspartner

Mouse (Murine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Interaktionspartner

  1. Mannose receptor (-/-) liver sinusoidal endothelial cells had markedly and significantly reduced enzyme activities for four out of five lysosomal enzymes tested, i.e., cathepsin-D, alpha-mannosidase, beta-hexosaminidase and arylsulfatase.

Human Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Interaktionspartner

  1. A novel heterozygous mutation (c.2013G>A; p.R638H) of MANBA (zeige MANBA ELISA Kits) was identified in patients with autosomal-dominant nystagmus. An additional mutation (c.2346T>A; p.L749H) in MANBA (zeige MANBA ELISA Kits) was found by screening patients with sporadic nystagmus.

  2. Our results indicate a correlation between the MAN2B1 genotypes and the cognitive function, upper limb coordination, balance, FVC% and the storage of oligosaccharides in CSF (zeige CSF2 ELISA Kits).

  3. The results showed that the alpha-mannosidosis patient has compound heterozygous mutations in the MAN2B1 gene

  4. MAN2B1 is targeted to the vacuole without passing through the Golgi complex.

  5. Expressed MAN2B1 and MAN2B2 (zeige MAN2B2 ELISA Kits) in Drosophila S2 cells and functionally characterized them. MAN2B1 and MAN2B2 (zeige MAN2B2 ELISA Kits) were significantly inhibited by the class II alpha-mannosidase inhibitors, swainsonine and mannostatin A.

  6. 5 new mutations were found in the MAN2B1 gene: c.157G>T, c.562C>T, c.599A>T, c.293dupA, c.2402G>A (p.E53X, p.R188X, p.H200L, p.Y99VfsX61, p.G801D). p.H200L could involve the catalytic mechanism. p.G801D would affect correct folding.

Cow (Bovine) Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Interaktionspartner

Mannosidase, Alpha, Class 2B, Member 1 (MAN2B1) Antigen-Profil

Beschreibung des Gens

This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MAN2B1

  • mannosidase, alpha, class 2B, member 1 (MAN2B1) Antikörper
  • mannosidase, alpha, class 2B, member 1 (man2b1) Antikörper
  • mannosidase 2, alpha B1 (Man2b1) Antikörper
  • mannosidase, alpha, class 2B, member 1 (Man2b1) Antikörper
  • AW107687 Antikörper
  • Laman Antikörper
  • MANB Antikörper

Bezeichner auf Proteinebene für MAN2B1

mannosidase, alpha, class 2B, member 1 , lysosomal alpha-mannosidase (109.3 kD) (XF355) , lysosomal alpha-mannosidase , lysosomal alpha-mannosidase-like , lysosomal acid alpha-mannosidase , mannosidase alpha class 2B member 1 , mannosidase alpha-B , mannosidase 2, alpha B1 , mannosidase, alpha B, lysosomal , laman

GENE ID SPEZIES
484932 Canis lupus familiaris
779924 Xenopus (Silurana) tropicalis
100010377 Monodelphis domestica
100174476 Pongo abelii
100395073 Callithrix jacchus
100598622 Nomascus leucogenys
17159 Mus musculus
100718205 Cavia porcellus
361378 Rattus norvegicus
4125 Homo sapiens
282272 Bos taurus
493697 Felis catus
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