Major Histocompatibility Complex, Class II, DM beta (HLA-DMB) ELISA Kits

HLA-DMB belongs to the HLA class II beta chain paralogues. Zusätzlich bieten wir Ihnen HLA-DMB Antikörper (70) und HLA-DMB Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human HLA-DMB HLA-DMB 3109 P28068
Anti-Ratte HLA-DMB HLA-DMB 294273  
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Weitere ELISA Kits für HLA-DMB Interaktionspartner

Human Major Histocompatibility Complex, Class II, DM beta (HLA-DMB) Interaktionspartner

  1. Data suggest that antigen processing by MHC class II HLA-DMB antigen is a target pathway in the pathogenesis of HIV-related Kaposi's sarcoma.

  2. DMA (zeige HLA-DMA ELISA Kits)*01:01 (69.35%) and DMB*01:01 (52.5%) alleles were more frequent in Chinese Hans

  3. Overexpression of HLA-DM at the plasma membrane of dendritic cells improves quantitatively, but also qualitatively, the presentation of CD4 (zeige CD4 ELISA Kits)-expressing T cell epitopes in cellular vaccine therapies for cancer.

  4. HLA-DM mediates a noncooperative release of prebound influenza virus hemagglutinin (zeige HA ELISA Kits) peptides from wild-type HLA-DR1 (zeige DR1 ELISA Kits) by destabilizing the beta81 hydrogen (H-)bond, since a similar phenomenon is observed when this H-bond is absent.

  5. HLA DMA (zeige HLA-DMA ELISA Kits) and DMB show no association with rheumatoid arthritis in US Caucasians.

  6. HLA-DMB may play an important role in pathogenesis of type 1 diabetes, and clinical status heterogeneity of type 1 diabetes may be related to genetic mechanism.

  7. glycosylation promotes, but is not essential for, DMalphabeta ER exit; single DMalpha chains cannot fully oxidize without DMbeta (zeige GPHb5 ELISA Kits), while DMbeta (zeige GPHb5 ELISA Kits) forms disulfide-linked homodimers without DMalpha

  8. findings suggest HLA-DM expression in antigen presenting cells controls class II-mediated type II collagen (zeige COL2A1 ELISA Kits)(261-273) peptide/epitope presentation & regulates CD4 (zeige CD4 ELISA Kits)+ T cell responses to this self epitope, potentially influencing CII-dependent autoimmunity

  9. Tumor cell expression of HLA-DMB is associated with increased numbers of tumor-infiltrating CD8 (zeige CD8A ELISA Kits) T lymphocytes and both are associated with improved survival in advanced-stage serous ovarian cancer.

  10. No individual component of conserved HLA-DM hydrogen bond network demonstrates an essential role in the DM catalytic mechanism. Catalytic potency of HLA-DM with each beta-chain mutant was equal to or greater than that observed with wild-type HLA-DR1 (zeige DR1 ELISA Kits).

HLA-DMB Antigen-Profil

Beschreibung des Gens

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Genbezeichner und Symbole assoziert mit HLA-DMB

  • major histocompatibility complex, class II, DM beta (HLA-DMB) Antikörper
  • RT1 class II, locus DMb (RT1-DMb) Antikörper
  • major histocompatibility complex, class II, DM beta (PATR-DMB) Antikörper
  • D6S221E Antikörper
  • MHC-DMB Antikörper
  • RING7 Antikörper
  • RT1.DMb Antikörper
  • RT1.Mb Antikörper

Bezeichner auf Proteinebene für HLA-DMB

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3109 Homo sapiens
294273 Rattus norvegicus
449592 Pan troglodytes
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